Results 231 to 240 of about 21,955 (252)

CD30 protects EBV-positive diffuse large B-cell lymphoma cells against mitochondrial dysfunction through BNIP3-mediated mitophagy.

Cancer Letters
Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (EBV+ DLBCL) predicts poor prognosis and CD30 expression aggravates the worse consequences.
Weiting Wang, T. Xing, Kaixin Du, W. Hua, Jin-Ran Guo, Zihui Duan, Yi-fan Wu, Jia-zhu Wu, Yue Li, H. Yin, Hao Shen, Li Wang, Jian-Yong Li, Jin-Hua Liang, Wei Xu   +14 more
semanticscholar   +1 more source

PGAM5 interacts with and maintains BNIP3 to license cancer-associated muscle wasting

Autophagy
Regressing the accelerated degradation of skeletal muscle protein is a significant goal for cancer cachexia management. Here, we show that genetic deletion of Pgam5 ameliorates skeletal muscle atrophy in various tumor-bearing mice.
Qingyuan Zhang, Chunhui Chen, Ye Ma, Xinyi Yan, Nian-hong Lai, Hao Wang, Baogui Gao, Anna Meilin Gu, Qinrui Han, Qingling Zhang, Lei La, Xuegang Sun   +11 more
semanticscholar   +1 more source

Polydatin: a potential NAFLD therapeutic drug that regulates mitochondrial autophagy through SIRT3-FOXO3-BNIP3 and PINK1-PRKN mechanisms - a network pharmacology and experimental investigation.

Chemico-Biological Interactions
Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disorder that is linked to metabolic syndrome, mitochondrial dysfunction and impaired autophagy.
Jing He, Yi-cai Qian, Ying-chuan Yin, Jingrui Kang, Tianhan Pan   +4 more
semanticscholar   +1 more source

BNip3 and signal-specific programmed death in the heart

Journal of Molecular and Cellular Cardiology, 2005
The BH3-only proteins, including BNip3, are members of the Bcl-2 family of cell death-regulating factors. Whereas proteins such as Bax and Bak play a central role in most forms of apoptosis, the BH3-only proteins appear to modulate apoptosis through cell type- and signal-specific pathways.
Keith A, Webster, Regina M, Graham, Nanette H, Bishopric   +2 more
openaire   +2 more sources

Thymidine phosphorylase inhibits the expression of proapoptotic protein BNIP3

Biochemical and Biophysical Research Communications, 2008
An angiogenic factor, thymidine phosphorylase (TP), confers resistance to apoptosis induced by hypoxia. We investigated the molecular basis for the suppressive effect of TP on hypoxia-induced apoptosis using Jurkat cells transfected with TP cDNA, Jurkat/TP, and a mock transfectant, Jurkat/CV.
Ryuji, Ikeda, Yusuke, Tajitsu, Ken-Ichi, Iwashita, Xiao-Fang, Che, Kenichi, Yoshida, Mina, Ushiyama, Tatsuhiko, Furukawa, Masaharu, Komatsu, Tatsuya, Yamaguchi, Yoshihiko, Shibayama, Masatatsu, Yamamoto, Hong-Ye, Zhao, Junko, Arima, Yasuo, Takeda, Shin-Ichi, Akiyama, Katsushi, Yamada   +15 more
openaire   +2 more sources

Involvement of Sirt1-FoxO3a-Bnip3 axis and autophagy mediated mitochondrial turnover in according protection to hyperglycemic NRK-52E cells by Berberine.

Toxicology in Vitro
Aberrant accumulation of dysfunctional mitochondria in renal cells during hyperglycemia signifies perturbed autophagy and mitochondrial turnover. This study aims to focus on the underlying mechanism involved in autophagy and mitophagy inducing efficacy ...
Sugandh Saxena, S. Anand, Ankita Sharma, Poonam Kakkar   +3 more
semanticscholar   +1 more source

BNIP3 up-regulation and mitochondrial dysfunction in manganese-induced neurotoxicity

NeuroToxicology, 2009
The central nervous system (CNS) appears to be the critical target of manganese (Mn), and neurotoxicity has been the focus of most of the health effects of manganese. In brain, the mechanism underlying the Mn-induced cell death is not clear. We have previously demonstrated that NFkappabeta induction and the activation of nitric oxide synthase through ...
Krishnan, Prabhakaran, Gail D, Chapman, Palur G, Gunasekar   +2 more
openaire   +2 more sources

Fangji Huangqi decoction ameliorates membranous nephropathy through the upregulation of BNIP3-mediated mitophagy.

Journal of Ethnopharmacology
ETHNOPHARMACOLOGICAL RELEVANCE Fangji Huangqi Decoction (FJHQ), a traditional Chinese medicinal formula outlined in Zhang Zhongjing's "Jin Gui Yao Lue" during the Han Dynasty, is often used to treat conditions characterized by symptoms like edema and ...
Yuxin Wang, Yuhua Ma, Yanrong Ke, Xiaocheng Jiang, Jian Liu, Yang Xiao, Hong Zheng, Chaojun Wang, Xue Chen, Manman Shi   +9 more
semanticscholar   +1 more source

Cannabinoids improve mitochondrial function in skeletal muscle of exhaustive exercise training rats by inhibiting mitophagy through the Pink1/Parkin and Bnip3 pathways.

Chemico-Biological Interactions
Cannabidiol (CBD) is a pure natural phytocannabinoid derived from cannabis that has anti-inflammatory, antiapoptotic and antioxidative stress abilities.
Juncheng Si, Lili Sun, Ying Qin, Lina Peng, Yongshan Gong, Chun-Chun Gao, Wenhui Shen, Mengqi Li   +7 more
semanticscholar   +1 more source

Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy

2017
Mitochondria are organelles with numerous vital roles in cellular metabolism. Impaired or damaged mitochondria are degraded in autophagolysosomes in a process known as mitophagy. Given the fundamental role of mitophagy in maintenance of cellular homeostasis, methods and techniques with which to study this process are constantly evolving and emerging ...
Matilda, Šprung, Ivan, Dikic, Ivana, Novak   +2 more
openaire   +2 more sources