Results 41 to 50 of about 23,915 (293)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Polymers and Polymer CompositesThe use of composite materials is widely spread across the Aerospace sector. Scarf and step lap joints are amongst the most commonly used methods for flush joint repairs; they restore original stiffness and nearly original strength.
Nabil M Chowdhury +3 more
doaj +1 more source
Fracture and Structural IntegrityFracture behavior of adhesive joints is an important topic in structural design of new structural elements or in retrofitting of existing ones. The mechanical models available in literature capable of predicting the failure mode of these junctions are ...
Michele Perrella +3 more
doaj +1 more source
Finite element analysis of bonded, riveted and hybrid joints in glass fibre epoxy composite laminates for aircraft structure [PDF]
E3S Web of ConferencesBecause of their superior fatigue resistance and high strength-to-weight ratio, composite materials are essential to the construction of modern airplanes.
Kulkarni Santosh +6 more
doaj +1 more source
Analysis of T-Peel Weld-Bonded Joint with Single Overlap Support [PDF]
, 2011 Bonded structure are commonly of three types, purely adhesive bonded, weld-bonded and adhesive/mechanical structures. Peel and overlapped joints are commonly used in the development of bonded structures. T-Peel bonded joint has week tensile strength load
Ali M. Al Samhan
core +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Surface structured bonded composite-metal joint [PDF]
, 2014 The design of structural joints is one of the critical challenges for the development of composite lightweight aircraft and motorsport structures. Despite the universal reliance upon mechanical fastening and adhesive bonding, the disadvantages of both
Di Giandomenico, Vincenzo
core
Tensile Strength Prediction of Woven Composite Bonded Joint [PDF]
, 2010 A progressive damage method is adopted to predict the structural strength of a woven out-of plane composite bonded π joint. A 3D progressive damage model is established and analyzed via a user defined subroutine embedded into the general FEA package. The
Hai Feng Chang +4 more
core +1 more source
Advanced Engineering Materials, EarlyView.Predicting extreme defects in additive manufacturing remains a key challenge limiting its structural reliability. This study proposes a statistical framework that integrates Extreme Value Theory with advanced process indicators to explore defect–process relationships and improve the estimation of critical defect sizes. The approach provides a basis for
Muhammad Muteeb Butt +8 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.A flexure‐based variable stiffness structure is developed by integrating phase‐change modulation and adhesive interfacial locking of gallium. The design enables a wide stiffness variability, transitioning from soft, flexible behavior to rigid, load‐supporting performance.
Sungjin Kim +2 more
wiley +1 more source