Results 21 to 30 of about 606,113 (264)

The HOXA gene cluster: a critical regulator in bone-related disorders [PDF]

Annals of Medicine
Background Skeletal homeostasis relies on the dynamic balance between bone formation and bone resorption. The disruption of this balance acts as the central pathological mechanism of multiple metabolic bone diseases including osteoporosis, and is closely
Yangyang Zhang, Lewei Zhang, Yi Li, Jia Bai, Haihong Lv   +4 more
doaj   +2 more sources

Role of senescent cells in bone-related diseases: An updated review [PDF]

Kouqiang yixue
Bone-related diseases are a group of inflammatory diseases characterized by abnormal bone resorption and formation, with a wide variety of diseases involving age, inflammation, obesity, genetics, radiation, and other pathogenic factors.
TANG Jinru, LI Bo, LIU Yunkun, HOU Zeyu, LI Longjiang
doaj   +2 more sources

Sonography of bone and bone‐related diseases of the extremities

Journal of Clinical Ultrasound, 2004
restriction
Kil Ho Cho, Young‐Hwan Lee, Sung‐Moon Lee, Muhammad Usman Shahid, Kyung Jin Suh, Joon Hyuk Choi   +5 more
openalex   +5 more sources

Circular RNAs: typical biomarkers for bone-related diseases. [PDF]

J Zhejiang Univ Sci B, 2022
Bone is a connective tissue that has important functions in the human body. Cells and the extracellular matrix (ECM) are key components of bone and are closely related to bone-related diseases. However, the outcomes of conventional treatments for bone-related diseases are not promising, and hence it is necessary to elucidate the exact regulatory ...
Hu L, Wu W, Zou J.
europepmc   +3 more sources

Emerging roles of the metabolite succinate in bone-related diseases. [PDF]

J Zhejiang Univ Sci B
Bone-related diseases, including osteoporosis (OP), osteoarthritis (OA), rheumatoid arthritis (RA), fracture, and periodontitis, significantly impact human health. Succinate, primarily known as a metabolic intermediate in the tricarboxylic acid (TCA) cycle, has emerged as a regulator of cellular functions beyond its metabolic role.
Wu Z, Dai Q, Wang Y, Wu N, Wang C, Shi J.   +5 more
europepmc   +3 more sources

Targeting type H vessels in bone-related diseases. [PDF]

J Cell Mol Med
AbstractBlood vessels are essential for bone development and metabolism. Type H vessels in bone, named after their high expression of CD31 and Endomucin (Emcn), have recently been reported to locate mainly in the metaphysis, exhibit different molecular properties and couple osteogenesis and angiogenesis.
Xu J, He SJ, Xia TT, Shan Y, Wang L.
europepmc   +3 more sources

Hyperbaric Oxygen Therapy for the Treatment of Bone-Related Diseases. [PDF]

Int J Mol Sci
Hyperbaric oxygen therapy (HBOT) is a therapeutic modality that enhances tissue oxygenation by delivering 100% oxygen at pressures greater than 1 absolute atmosphere. In recent years, HBOT has shown considerable potential in the treatment of bone diseases.
Feng J, Zhu C, Zou J, Zhang L.
europepmc   +3 more sources

Circulating and extracellular vesicle-derived microRNAs as biomarkers in bone-related diseases. [PDF]

Front Endocrinol (Lausanne), 2023
MicroRNAs (miRNA) are small non-coding RNA molecules that regulate posttranscriptional gene expression by repressing messengerRNA-targets. MiRNAs are abundant in many cell types and are secreted into extracellular fluids, protected from degradation by packaging in extracellular vesicles.
Huber J, Longaker MT, Quarto N.
europepmc   +4 more sources

Advances in copper-containing biomaterials for managing bone-related diseases. [PDF]

Regen Biomater
Abstract Bone-related diseases pose a major challenge in contemporary society, with significant implications for both health and economy. Copper, a vital trace metal in the human body, facilitates a wide range of physiological processes by being crucial for the function of proteins and enzymes.
Li K, Cao H, Huang H, Tang S, Wang H, Yang Q, Hu Y, Weng J, Chen X.   +8 more
europepmc   +3 more sources

Nrf2: A promising therapeutic target in bone-related diseases

Biomedicine & Pharmacotherapy, 2023
Nuclear factor erythroid-2-related factor 2 (Nrf2) plays an important role in maintaining cellular homeostasis, as it suppresses cell damage caused by external stimuli by regulating the transcription of intracellular defense-related genes. Accumulating evidence has highlighted the crucial role of reduction-oxidation (REDOX) imbalance in the development
Jingmin Che, Xiaoli Yang, Zhankui Jin, Cuixiang Xu   +3 more
openaire   +2 more sources