Results 1 to 10 of about 1,337,429 (212)

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

Scientific Reports, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Yael Alippe, Chun Wang, Biancamaria Ricci, Jianqiu Xiao, Chao Qu, Wei Zou, Deborah V. Novack, Yousef Abu-Amer, Roberto Civitelli, Gabriel Mbalaviele   +9 more
doaj   +3 more sources

Necrostatin-1 Alleviates Diffuse Pulmonary Haemorrhage by Preventing the Release of NETs via Inhibiting NE/GSDMD Activation in Murine Lupus

Journal of Immunology Research, 2023
Diffuse alveolar haemorrhage (DAH) is a rapidly developing condition owing to a lack of effective treatment and resulting in a high mortality rate in systemic lupus erythematosus (SLE).
Xinai Han, Xiaoming Zhang, Rui Song, Shiqi Li, Shujing Zou, Quanguang Tan, Tianyang Liu, Shugeng Luo, Zhe Wu, Hongyu Jie, Jinhong Wang   +10 more
doaj   +1 more source

Hemostatic and thrombotic parameters in acure leukemia- A comparison of pre and post remission induction phase

Liaquat Medical Research Journal, 2022
This study was aimed to compare hemostatic, fibrinolytic and thrombotic parameters in pre and post induction chemotherapy in acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL).
Tehmina Nafees Sonia Khan, Tariq Masood, Zara tul ain Bashir, Tasneem Farzana, Abdul Sattar, Tahir Shamsi   +5 more
doaj   +1 more source

Anthropometrics of Polish children with osteogenesis imperfecta: a single-centre retrospective cohort study

BMC Pediatrics, 2022
Background Osteogenesis imperfecta (OI) causes a number of abnormalities in somatic development. The predominant symptoms are reduced bone mass and an increased risk of fractures as well as bone deformities and short stature.
E. Jakubowska-Pietkiewicz, A. Maćkowska, J. Nowicki, E. Woźniak, Nowicki Jakub   +4 more
doaj   +1 more source

A distinct molecular mutational profile and its clinical impact in essential thrombocythemia and primary myelofibrosis patients

BMC Cancer, 2020
Background Classical MPNs including ET and PMF have a chronic course and potential for leukaemic transformation. Timely diagnosis is obligatory to ensure appropriate management and positive outcomes.
Uzma Zaidi, Gul Sufaida, Munazza Rashid, Bushra Kaleem, Sidra Maqsood, Samina Naz Mukry, Rifat Zubair Ahmed Khan, Saima Munzir, Munira Borhany, Tahir Sultan Shamsi   +9 more
doaj   +1 more source

Identification of gene polymorphisms associated with fat mass by genome-wide association study in Chinese people

Archives of Medical Science, 2023
Introduction This study aimed to investigate the relationship of gene polymorphisms and fat mass (FM) in Chinese population. Material and methods Healthy males, premenopausal and postmenopausal women were recruited. Single Nucleotide Polymorphisms (SNPs)
Luyue Qi, Zhenlin Zhang, Weiwei Hu
doaj   +1 more source

Development of Bone Targeting Drugs. [PDF]

, 2017
The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage
Alméciga-Díaz, Carlos J., Mackenzie, William G., Mason, Robert W., Orii, Tadao, Sawamoto, Kazuki, Stapleton, Molly, Tomatsu, Shunji   +6 more
core   +2 more sources

Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing [PDF]

, 2020
Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs) negatively influence bone metabolism and fracture healing.
Brinkman, Antonia Clara Katharina, Burmester, Gerd-Rüdiger, Buttgereit, Frank, Damerau, Alexandra, Diesing, Karoline, Gaber, Timo, Hoff, Paula, Lang, Annemarie, Ohrndorf, Sarah, Pfeiffenberger, Moritz, Pienczikowski, Justyna   +10 more
core   +1 more source

Association of HIVEP3 Gene and Lnc RNA with Femoral Neck Bone Mineral Content and Hip Geometry by Genome-Wide Association Analysis in Chinese People

International Journal of Endocrinology, 2020
Purpose. GWAS has successfully located and analyzed the pathogenic genes of osteoporosis. Genetic studies have found that heritability of BMD is 50%–85% while the other half is caused by hip geometric parameters and tissue horizontal characteristics ...
Weiwei Hu, Jinwei He, Luyue Qi, Chun Wang, Hua Yue, Jiemei Gu, Hao Zhang, Yi Wang, Zhenlin Zhang   +8 more
doaj   +1 more source

Environmental and occupational determinants of myelodysplastic syndrome: A case–control study from Pakistan

Cancer Reports, 2022
Background Myelodysplastic syndromes (MDS) are heterogeneous group of haematopoietic stem cell disorders and have variable reduction in the production of red cells, platelets and mature granulocytes.
Nida Anwar, Aisha Arshad, Naveena Fatima, Sumaira Shaheen, Sumera Bukhari, Tahir Shamsi   +5 more
doaj   +1 more source