Results 101 to 110 of about 1,355,503 (353)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Strontium ranelate: A novel mode of action leading to renewed bone quality [PDF]

, 2018
Various bone resorption inhibitors and bone stimulators have been shown to decrease the risk of osteoporotic fractures. However, there is still a need for agents promoting bone formation by inducing positive uncoupling between bone formation and bone ...
Ammann, Patrick
core  

Stable sulforaphane protects against gait anomalies and modifies bone microarchitecture in the spontaneous STR/Ort model of osteoarthritis [PDF]

, 2017
Osteoarthritis (OA), affecting joints and bone, causes physical gait disability with huge socio-economic burden; treatment remains palliative. Roles for antioxidants in protecting against such chronic disorders have been examined previously. Sulforaphane
Ahmed Aljazzar, Alam, Andrea Pollard, Andrew A. Pitsillides, Behzad Javaheri, Bellido, Blandine Poulet, Boris Chan, Brewster, Carbone, Castañeda, Chambers, Chambers, Chiusaroli, Christiansen, Clarke, Conaghan, Custers, Davidson, Davidson, Doube, Duarte, Elaine Shervill, Foster, Glasson, Glasson, Goldring, Goldring, Haseeb, Hayami, Henrotin, Ho, Hochman, Isabel R. Orriss, Javaheri, Javaheri, Juge, Juhl, Karsdal, Kim, Li, Little, Lo, Mark Hopkinson, Mason, Miriam Piles, Mündermann, Pasold, Pastoureau, Pauli, Pearson, Peter D. Lee, Piles, Poulet, Poulet, Poulet, Poulet, Poulet, Pritzker, Radin, Roberto de Souza, Scheller, Schnitzer, Tat, Taylor, Thaler, Uchida, Valdes, Vincelette, Wang, Wu, Xiao, Yu-Mei Chang, Zakkar   +73 more
core   +3 more sources

POS0047 THE COMPLEMENT FACTOR H-RELATED PROTEIN-5 EXACERBATES PATHOLOGICAL BONE FORMATION OF ANKYLOSING SPONDYLITIS [PDF]

, 2023
Chang‐Nam Son, Jaejoon Lee, Sungsin Jo, Il‐Hoon Sung, T. H. Kim   +4 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Current Topics in Pharmacological Research on Bone Metabolism: Regulation of Bone Mass by the Function of Endogenous Modulators of Bone Morphogenetic Protein in Adult Stage

Journal of Pharmacological Sciences, 2006
.: Bone formation in adults determines the basic mass of bone and hence it is crucial to understand the mechanisms of its regulation. As remodeling is proceeding, bone resorption is determined by the physical conditions.
Masaki Noda
doaj   +1 more source

Immunogold localization of beta 1-integrin in bone: effect of glucocorticoids and insulin-like growth factor I on integrins and osteocyte formation. [PDF]

, 1995
Anita Gohel, Arthur R. Hand, Gloria Gronowicz   +2 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source