Results 41 to 50 of about 562,868 (214)

VEGF incorporated into calcium phosphate ceramics promotes vascularisation and bone formation in vivo [PDF]

European Cells & Materials, 2010
Bone formation and osseointegration of biomaterials are dependent on angiogenesis and vascularization. Angiogenic growth factors such as vascular endothelial growth factor (VEGF) were shown to promote biomaterial vascularization and enhance bone ...
E Wernike, M-O Montjovent, Y Liu, D Wismeijer, EB Hunziker, K-A Siebenrock, W Hofstetter, FM Klenke   +7 more
doaj  

Circadian rhythms affect bone reconstruction by regulating bone energy metabolism

Journal of Translational Medicine, 2021
Metabolism is one of the most complex cellular biochemical reactions, providing energy and substances for basic activities such as cell growth and proliferation. Early studies have shown that glucose is an important nutrient in osteoblasts.
Beibei Luo, Xin Zhou, Qingming Tang, Ying Yin, Guangxia Feng, Shue Li, Lili Chen   +6 more
doaj   +1 more source

Toll-like receptor-2 induced inflammation causes local bone formation and activates canonical Wnt signaling

Frontiers in Immunology
It is well established that inflammatory processes in the vicinity of bone often induce osteoclast formation and bone resorption. Effects of inflammatory processes on bone formation are less studied.
Petra Henning, Ali Kassem, Anna Westerlund, Pernilla Lundberg, Cecilia Engdahl, Cecilia Engdahl, Vikte Lionikaite, Pernilla Wikström, Jianyao Wu, Lei Li, Catharina Lindholm, Catharina Lindholm, Pedro P. C. de Souza, Sofia Movérare-Skrtic, Ulf H. Lerner, Ulf H. Lerner   +15 more
doaj   +1 more source

Re-tuning bone formation [PDF]

Journal of Experimental Medicine, 2015
![Figure][1] Insight from Gerard Karsenty Fibrillin-1 (FBN1) is a structural component of microfibrils in the extracellular matrix that plays a role in tissue development. Genetic defects in FBN1 are associated with a number of clinical conditions including systemic sclerosis (SSc)/
openaire   +3 more sources

The induction of bone formation by 3D-printed PLGA microsphere scaffolds in a calvarial orthotopic mouse model: a pilot study

Frontiers in Bioengineering and Biotechnology
Polymeric biodegradable microspheres are readily utilized to support targeted drug delivery for various diseases clinically. 3D printed tissue engineering scaffolds from polymer filaments with embedded microspheres or nanoparticles, as well as bulk ...
Roland M. Klar, James C. Cox, Claire J. Houchen, Naren Raja, Houssam Bouloussa, Stefan Lohfeld   +5 more
doaj   +1 more source

Effect of genistin on bone formation

Frontiers in Bioscience, 2010
The amount of new bone produced by grafting genistin in collagen matrix was compared to the bone produced by collagen matrix alone. A total of 18 bone defects (5 mm by 10 mm) were created in the parietal bone of 9 New Zealand White rabbits. Six defects were grafted with genistin mixed with collagen matrix, while 6 were grafted with collagen matrix ...
Rabie, AB, Wong, RW
openaire   +4 more sources

Pathogenesis of thoracic ossification of the ligamentum flavum

Frontiers in Pharmacology
Thoracic ossification of the ligamentum flavum (TOLF) is characterized by ectopic ossification of the ligamentum flavum in the thoracic spine and is considered the main cause of thoracic spinal stenosis and spinal cord disease.
Chi Zhang, Chi Zhang, Chi Zhang, Yanan Chang, Li Shu, Zhongqiang Chen   +5 more
doaj   +1 more source

Tensile Stress‐Activated and Exosome‐Transferred YAP/TAZ‐Notch Circuit Specifies Type H Endothelial Cell for Segmental Bone Regeneration

Advanced Science
The Ilizarov technique has been continuously innovated to utilize tensile stress (TS) for inducing a bone development‐like regenerative process, aiming to achieve skeletal elongation and reconstruction.
Feng Wang, Shanyu Li, Lingchi Kong, Kai Feng, Rongtai Zuo, Hanzhe Zhang, Yifan Yu, Kunqi Zhang, Yuting Cao, Yimin Chai, Qinglin Kang, Jia Xu   +11 more
doaj   +1 more source

Hypothesis: Coupling between resorption and formation in cancellous bone remodeling is a mechanically controlled event

Frontiers in Endocrinology, 2015
Coupling is the process that links bone resorption to formation in a temporally and spatially coordinated manner within the remodeling cycle. In order to maintain skeletal integrity, it is of crucial importance that the amount of bone resorbed matches ...
Reinhold Gottfried Erben
doaj   +1 more source

Constitutive bone marrow adipocytes suppress local bone formation

JCI Insight, 2022
BM adipocytes (BMAd) are a unique cell population derived from BM mesenchymal progenitors and marrow adipogenic lineage precursors. Although they have long been considered to be a space filler within bone cavities, recent studies have revealed important ...
Ziru Li, Devika P. Bagchi, Junxiong Zhu, Emily Bowers, Hui Yu, Julie Hardij, Hiroyuki Mori, Katrina Granger, Jon Skjaerlund, Gurjit Mandair, Simin Abrishami, Kanakadurga Singer, Kurt D. Hankenson, Clifford J. Rosen, Ormond A. MacDougald   +14 more
doaj   +1 more source