Results 21 to 30 of about 374,545 (305)

Polycyclic aromatic hydrocarbons in bone homeostasis

Biomedicine & Pharmacotherapy, 2022
Prolonged exposure to polycyclic aromatic hydrocarbons (PAHs) may result in autoimmune diseases, such as rheumatoid arthritis (RA) and osteoporosis (OP), which are based on an imbalance in bone homeostasis. These diseases are characterized by bone erosion and even a disruption in homeostasis, including in osteoblasts and osteoclasts.
Qinbin, Ye, Xiaoyu, Xi, Danping, Fan, Xiaoxue, Cao, Qiong, Wang, Xing, Wang, Mengxiao, Zhang, Bailiang, Wang, Qingwen, Tao, Cheng, Xiao   +9 more
openaire   +2 more sources

Advances in the Study of Exosomes as Drug Delivery Systems for Bone-Related Diseases

Pharmaceutics, 2023
Bone-related diseases are major problems and heavy burdens faced by modern society. Current clinical approaches for the treatment of these pathological conditions often lead to complications and have limited therapeutic efficacy.
Jiawen Huang, Yang Xu, Yuxuan Wang, Zhiang Su, Tingting Li, Sisi Wu, Yuheng Mao, Shihua Zhang, Xiquan Weng, Yu Yuan   +9 more
doaj   +1 more source

Nutrition-Related Peptides and Bone Homeostasis [PDF]

Journal of Bone and Mineral Research, 2006
THE SKELETON SERVES two main functions. First, it has a structural role, to support, protect, and facilitate the function of the soft tissues. Second, it is a mineral reservoir, which can be drawn on when dietary intake is inadequate to meet the body’s needs.
Ian R, Reid, Jillian, Cornish, Paul A, Baldock   +2 more
openaire   +2 more sources

Insulin Receptor deletion in S100a4-lineage cells accelerates age-related bone loss

Bone Reports, 2019
Type I and Type II Diabetes dramatically impair skeletal health. Altered Insulin Receptor (IR) signaling is a common feature of both diseases, and insulin has potent bone anabolic functions.
Valentina Studentsova, Emma Knapp, Alayna E. Loiselle   +2 more
doaj   +1 more source

The role of Nrf2 in periodontal disease by regulating lipid peroxidation, inflammation and apoptosis

Frontiers in Endocrinology, 2022
Nuclear factor E2-related factor 2(Nrf2) is a transcription factor that mainly regulates oxidative stress in the body. It initiates the expression of several downstream antioxidants, anti-inflammatory proteins and detoxification enzymes through the Kelch-
Fengyu Ma, Fengyu Ma, Shangdie Luo, Chunting Lu, Xinrong Jiang, Xinrong Jiang, Kexiao Chen, Kexiao Chen, Jianwen Deng, Jianwen Deng, Shuyuan Ma, Zejian Li, Zejian Li, Zejian Li   +13 more
doaj   +1 more source

Skeletal homeostasis in tissue‐engineered bone [PDF]

Journal of Orthopaedic Research, 2003
AbstractTissue‐engineering strategies to stimulate bone regeneration may offer an alternative approach to conventional orthopaedic and maxillofacial surgical therapies. Over the last decade, significant advances have been accomplished in developing biomimetic matrices, growth factors, cell transplantation and gene delivery therapeutics to support new ...
Schneider, Abraham, Taboas, Juan M., McCauley, Laurie K., Krebsbach, Paul H.   +3 more
openaire   +3 more sources

Complement involvement in bone homeostasis and bone disorders

Seminars in Immunology, 2018
An integral part of innate immunity is the complement system, a defence system, consisting of fluid-phase and cell surface-bound proteins. Its role to ensure adequate responses to danger factors and thus promoting host defence against pathogens has been well described already for decades. Recently, numerous further reaching functions of complement have
Yvonne, Mödinger, Bettina, Löffler, Markus, Huber-Lang, Anita, Ignatius   +3 more
openaire   +2 more sources

Small-molecule amines: a big role in the regulation of bone homeostasis

Bone Research, 2023
Numerous small-molecule amines (SMAs) play critical roles in maintaining bone homeostasis and promoting bone regeneration regardless of whether they are applied as drugs or biomaterials.
Qian Zhang, Jirong Yang, Nan Hu, Juan Liu, Huan Yu, Haobo Pan, Di Chen, Changshun Ruan   +7 more
doaj   +1 more source

Zinc Homeostasis in Bone: Zinc Transporters and Bone Diseases [PDF]

International Journal of Molecular Sciences, 2020
Zinc is an essential micronutrient that plays critical roles in numerous physiological processes, including bone homeostasis. The majority of zinc in the human body is stored in bone. Zinc is not only a component of bone but also an essential cofactor of many proteins involved in microstructural stability and bone remodeling.
Tongling Huang, Guoyong Yan, Min Guan
openaire   +2 more sources

Effect of pilose antler polypeptide on the mechanism of bone homeostasis in osteoporosis

Frontiers in Medicine, 2023
Osteoporosis stands out as a prevalent metabolic disorder, bearing significant repercussions on human well-being and overall quality of life. It remains an urgent concern within the global public health framework due to its widespread occurrence ...
Guochen Wang, Guochen Wang, Yubo Meng, Yubo Meng, Wensi Ouyang, Wensi Ouyang, Changwei Zhao, Changwei Zhao, Wenhai Zhao, Wenhai Zhao   +9 more
doaj   +1 more source