Bone Marrow: The Central Immune System
Bone marrow is known as the site of hematopoiesis. What is not being described in textbooks of immunology is the fact that bone marrow is not only a generative, but also an antigen-responsive, immune organ.
Volker Schirrmacher
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Profoundly reduced neovascularization capacity of bone marrow mononuclear cells derived from patients with chronic ischemic heart disease [PDF]
Background— Cell therapy with bone marrow–derived stem/progenitor cells is a novel option for improving neovascularization and cardiac function in ischemic heart disease.
Aicher, A+8 more
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Clinical relevance of circulating tumour cells in the bone marrow of patients with SCCHN [PDF]
Background: Clinical outcome of patients with head and neck squamous cell carcinoma (SCCHN) depends on several risk factors like the presence of locoregional lymph node or distant metastases, stage, localisation and histologic differentiation of the ...
Andratschke, M.+5 more
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Donor hematopoietic progenitor cells in nonmyeloablated rat recipients of allogeneic bone marrow and liver grafts [PDF]
Background. Although the persistence of multilineage microchimerism in recipients of long-surviving organ transplants implies engraftment of migratory pluripotent donor stem cells, the ultimate localization in the recipient of these cells has not been ...
Demetris, AJ+5 more
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Spindle cell lesion in the bone marrow [PDF]
![Figure][1] A 60-year-old man with myeloma treated with lenalidomide-bortezomib-dexamethasone (4 cycles) and carfilzomib-cyclophosphamide-dexamethasone (4 cycles) presented for a routine follow-up bone marrow scan.
Sumire Kitahara, Samuel Guzman
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Probing the interaction forces of prostate cancer cells with collagen I and bone marrow derived stem cells on the single cell level. [PDF]
Adhesion of metastasizing prostate carcinoma cells was quantified for two carcinoma model cell lines LNCaP (lymph node-specific) and PC3 (bone marrow-specific).
Benoit, Martin+7 more
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IFNα-mediated remodeling of endothelial cells in the bone marrow niche
In the bone marrow, endothelial cells are a major component of the hematopoietic stem cell vascular niche and are a first line of defense against inflammatory stress and infection.
Áine M. Prendergast+5 more
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Toxic effects of various zinc dosages on poultry hemopoiesis [PDF]
The aim of the study was to determine the main patterns of the manifestation of the toxic effect of zinc chloride on the cells of the red bone marrow in the first three days after exposure. Our experiment involved broiler chickens of the “Smena-7” cross.
Vishnyakov Aleksandr
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A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus [PDF]
A quantitative Abelson murine leukemia virus (A-MuLV) lymphoid cell transformation assay has been developed using a semisolid agarose culture system. Under these conditions lymphoid cell transformation was shown to vary linearly with the dose of A-MuLV ...
Baltimore, David, Rosenberg, Naomi
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Splenocytes seed bone marrow of myeloablated mice: implication for atherosclerosis. [PDF]
Extramedullary hematopoiesis has been shown to contribute to the pathogenesis of a variety of diseases including cardiovascular diseases. In this process, the spleen is seeded with mobilized bone marrow cells that augment its hematopoietic ability. It is
Lai Wang+10 more
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