The Role of Extracellular Vesicles MicroRNAs in Sarcopenia: From Aging to Multi‐Morbidity
AGING MEDICINE, EarlyView.Exosomes transporting miRNAs play a crucial bidirectional regulatory role in the process of sarcopenia, both in natural aging and under various pathological conditions. ABSTRACT Sarcopenia, defined as progressive loss of skeletal muscle mass and function, occurs during aging and has also been recognized for its detrimental effects in various disease ...
Bingyu Huang, Zhao Peng, Lin Kang
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Exercise rejuvenates bone marrow mesenchymal stem cells associated with the inhibition of inflammatory factors and senescence-related factors. [PDF]
Biochem Biophys RepDong XJ +5 more
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Annals of Gastroenterological Surgery, EarlyView.ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba +4 more
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Effects of fatty acids and cholesterol on functions and behavior of bone marrow mesenchymal stem cells. [PDF]
iScienceGonzalez-Garcia B +6 more
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Advanced Intelligent Discovery, EarlyView.A novel machine learning approach classifies macrophage phenotypes with up to 98% accuracy using only nuclear morphology from DAPI‐stained images. Bypassing traditional surface markers, the method proves robust even on complex textured biomaterial surfaces. It offers a simpler, faster alternative for studying macrophage behavior in various experimental
Oleh Mezhenskyi +5 more
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Artificial Intelligence for Bone: Theory, Methods, and Applications
Advanced Intelligent Discovery, EarlyView.Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan +3 more
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The therapeutic potential of bone marrow mesenchymal stem cells-derived exosomes for retinal and optic nerve diseases. [PDF]
Front Cell Dev BiolShi M, Qi S, Qi F, Wang C.
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Uncertainty‐Guided Selective Adaptation Enables Cross‐Platform Predictive Fluorescence Microscopy
Advanced Intelligent Discovery, EarlyView.Deep learning models often fail when transferred to new microscopes. A novel framework overcomes this by selectively adapting the early layers governing low‐level image statistics, while freezing deep layers that encode morphology. This uncertainty‐guided approach enables robust, label‐free virtual staining across diverse systems, democratizing ...
Kai‐Wen K. Yang +9 more
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Altered lineage commitment of bone marrow mesenchymal stem cells in idiopathic osteonecrosis of the femoral head. [PDF]
World J OrthopCardín-Pereda A +4 more
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Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.Magnetic soft robots offer promise in biomedicine due to their wireless actuation and rapid response, but current fabrication methods are complex and have limited cellular compatibility. A new, contactless bioassembly strategy using hydrodynamic instabilities is introduced, enabling customizable, centimeter‐scale robots.
Wei Gao +5 more
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