Results 41 to 50 of about 2,554,329 (307)

Dissecting Tumor-Stromal Interactions in Breast Cancer Bone Metastasis [PDF]

Endocrinology and Metabolism, 2016
Bone metastasis is a frequent occurrence in breast cancer, affecting more than 70% of late stage cancer patients with severe complications such as fracture, bone pain, and hypercalcemia.
Yibin Kang
doaj   +1 more source

CST6 protein and peptides inhibit breast cancer bone metastasis by suppressing CTSB activity and osteoclastogenesis

Theranostics, 2021
Background: Bone metastasis is a frequent symptom of breast cancer and current targeted therapy has limited efficacy. Osteoclasts play critical roles to drive osteolysis and metastatic outgrowth of tumor cells in bone.
Xiaoxun Li, Yajun Liang, Cheng Lian, Fangli Peng, Yansen Xiao, Yunfei He, Chengxin Ma, Yuan Wang, Peiyuan Zhang, Yuhan Deng, Yunpeng Su, Chengyao Luo, Xiangyin Kong, Qing-cheng Yang, Tong Liu, G. Hu   +15 more
semanticscholar   +1 more source

FAIM2 Promotes Non-Small Cell Lung Cancer Cell Growth and Bone Metastasis by Activating the Wnt/β-Catenin Pathway

Frontiers in Oncology, 2021
AimBone metastasis is the major reason for the poor prognosis and high mortality rate of non-small cell lung cancer (NSCLC) patients. This study explored the function and underlying mechanism of Fas apoptotic inhibitory molecule 2 (FAIM2) in the bone ...
Kelin She, Kelin She, Kelin She, Kelin She, Wensheng Yang, Mengna Li, Mengna Li, Mengna Li, Wei Xiong, Wei Xiong, Wei Xiong, Ming Zhou, Ming Zhou, Ming Zhou   +13 more
doaj   +1 more source

Formation of pre-metastatic bone niche in prostate cancer and regulation of traditional chinese medicine

Frontiers in Pharmacology, 2022
Prostate cancer with bone metastasis has a high cancer-specific mortality. Thus, it is essential to delineate the mechanism of bone metastasis. Pre-metastatic niche (PMN) is a concept in tumor metastasis, which is characterized by tumor-secreted factors,
Chiwei Chen, Renlun Huang, Jianfu Zhou, Lang Guo, Songtao Xiang   +4 more
doaj   +1 more source

Mortality following bone metastasis and skeletal-related events among patients 65 years and above with lung cancer: A population-based analysis of U.S. Medicare beneficiaries, 1999-2006

Lung India, 2013
Background: To quantify the impact of bone metastasis and skeletal-related events (SREs) on mortality among older patients with lung cancer. Materials and Methods: Using the linked Surveillance, Epidemiology and End Results-Medicare database, we ...
Nalini Sathiakumar, Elizabeth Delzell, Michael A Morrisey, Carla Falkson, Mellissa Yong, Victoria Chia, Justin Blackburn, Tarun Arora, Meredith L Kilgore   +8 more
doaj   +1 more source

Correlation of the Levels of the Bone Turnover Markers BAP and β-CTX with Bone Metastasis Progress in Lung Cancer Patients

Chinese Journal of Lung Cancer, 2013
Background and objective Bone metastasis is common in lung cancer patients. The β isomer of the C-terminal telopeptide of type I collagen (β-CTX) and bone-specific alkaline phosphates (BAP) are regarded as important bone turnover markers in bone ...
Qiong TANG, Hui ZHAO, Rui JIA, Linlin LIU   +3 more
doaj   +1 more source

NKX2-8/PTHrP Axis-Mediated Osteoclastogenesis and Bone Metastasis in Breast Cancer

Frontiers in Oncology, 2022
Bone metastasis is one of the most common distant metastasis of breast cancer, which could cause serious skeletal disease and increased cancer-related death.
Ainiwaerjiang Abudourousuli, Ainiwaerjiang Abudourousuli, Suwen Chen, Suwen Chen, Yameng Hu, Yameng Hu, Wanying Qian, Wanying Qian, Xinyi Liao, Xinyi Liao, Yingru Xu, Yingru Xu, Libing Song, Shuxia Zhang, Jun Li, Jun Li   +15 more
doaj   +1 more source

Bone Metastasis: Mechanisms, Therapies and Biomarkers.

Physiological Reviews, 2020
Skeletal metastases are frequent complications of many cancers, causing bone complications (fractures, bone pain, disability), which negatively affect the patient's quality of life.
P. Clézardin, R. Coleman, M. Puppo, P. Ottewell, E. Bonnelye, F. Paycha, C. Confavreux, I. Holen   +7 more
semanticscholar   +1 more source

Trends in Bone Metastasis Modeling [PDF]

Cancers, 2020
Bone is one of the most common sites for cancer metastasis. Bone tissue is composed by different kinds of cells that coexist in a coordinated balance. Due to the complexity of bone, it is impossible to capture the intricate interactions between cells under either physiological or pathological conditions.
Laranga R., Duchi S., Ibrahim T., Guerrieri A. N., Donati D. M., Lucarelli E.   +5 more
openaire   +4 more sources

Hallmarks of Bone Metastasis [PDF]

Calcified Tissue International, 2017
Breast cancer bone metastasis develops as the result of a series of complex interactions between tumor cells, bone marrow cells, and resident bone cells. The net effect of these interactions are the disruption of normal bone homeostasis, often with significantly increased osteoclast and osteoblast activity, which has provided a rational target for ...
Rachelle W. Johnson, Larry J. Suva
openaire   +2 more sources