Results 71 to 80 of about 2,554,329 (307)

Bone metastasis prediction in non-small-cell lung cancer: primary CT-based radiomics signature and clinical feature

BMC Medical Imaging
Background Radiomics provided opportunities to quantify the tumor phenotype non-invasively. This study extracted contrast-enhanced computed tomography (CECT) radiomic signatures and evaluated clinical features of bone metastasis in non-small-cell lung ...
Zheng Liu, Rui Yin, Wenjuan Ma, Zhijun Li, Yijun Guo, Haixiao Wu, Yile Lin, Vladimir P. Chekhonin, Karl Peltzer, Huiyang Li, Min Mao, Xiqi Jian, Chao Zhang   +12 more
doaj   +1 more source

The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis

Frontiers in Oncology, 2014
Prostate cancer (PCa) is the second leading cause of cancer death in men worldwide. Most PCa patients die with osteoblastic bone metastases. What triggers PCa metastasis to the bone and what causes osteoblastic lesions remain unanswered.
Sourik S Ganguly, Xiaohong eLi, Cindy K Miranti   +2 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Bone metastasis classification using whole body images from prostate cancer patients based on convolutional neural networks application

PLoS ONE, 2020
Bone metastasis is one of the most frequent diseases in prostate cancer; scintigraphy imaging is particularly important for the clinical diagnosis of bone metastasis.
N. Papandrianos, E. Papageorgiou, Athanasios Anagnostis, Konstantinos Papageorgiou   +3 more
semanticscholar   +1 more source

Treatment of Bone Metastasis

Current Oncology, 2022
The incidence of metastatic bone disease is increasing, as patients with cancer are living longer [...]
openaire   +3 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Clinical characteristics and prognoses in pediatric neuroblastoma with bone or liver metastasis: data from the SEER 2010–2019

BMC Pediatrics
Background To investigate clinical characteristics, prognoses, and impacts of treatments on prognoses of neuroblastoma patients with bone or liver metastasis. Methods This retrospective cohort study extracted data from the Surveillance, Epidemiology, and
Xudong Zhao, Zhuofan Xu, Xiaochuan Feng
doaj   +1 more source

Roles of calcium signaling in cancer metastasis to bone

Exploration of Targeted Anti-tumor Therapy, 2022
Bone metastasis is a frequent complication for cancers and an important reason for the mortality in cancer patients. After surviving in bone, cancer cells can cause severe pain, life-threatening hypercalcemia, pathologic fractures, spinal cord ...
Tianying Xie, Sitong Chen, Jiang Hao, Pengfei Wu, Xuelian Gu, Haifeng Wei, Zhenxi Li, Jianru Xiao   +7 more
doaj   +1 more source

Prognosis of prostate cancer and bone metastasis pattern of patients: a SEER-based study and a local hospital based study from China

Scientific Reports, 2020
Prostate cancer (PCa) is the leading cause of cancer-related death among men worldwide. Knowledge of the prognostic factors of PCa and the bone metastasis pattern of patients would be helpful for patients and doctors.
Dongyu Liu, Yue Kuai, Ruohui Zhu, Chenhe Zhou, Yiqing Tao, W. Han, Qixin Chen   +6 more
semanticscholar   +1 more source