Results 1 to 10 of about 137,665 (299)
Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling [PDF]
Open Biology, 2014 Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8.
Janis Vogt +7 more
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Activin‐A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type‐II Receptor Expression [PDF]
Pulmonary CirculationActivin‐A is elevated in pulmonary arterial hypertension (PAH) patients, and reportedly suppresses BMPR‐II. This suggests one mechanism of action for PAH drug, sotatercept, an activin‐ligand trap. However, we were unable to confirm that activin‐A reduces
Benjamin J. Dunmore +4 more
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Increased BMP-Smad signaling does not affect net bone mass in long bones
Frontiers in Physiology, 2023 Bone morphogenetic proteins (BMPs) have been used for orthopedic and dental application due to their osteoinductive properties; however, substantial numbers of adverse reactions such as heterotopic bone formation, increased bone resorption and greater ...
Maiko Omi +5 more
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The biology of bone morphogenetic protein signaling pathway in cerebrovascular system
Chinese Neurosurgical Journal, 2021 Bone morphogenetic protein belongs to transcription growth factor superfamily β; bone morphogenetic protein signal pathway regulates cell proliferation, differentiation, and apoptosis among different tissues.
Haishuang Tang +10 more
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Bone Morphogenetic Proteins [PDF]
Cold Spring Harbor Perspectives in Biology, 2016 Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in extracts derived from bone, are now known to play important roles in a wide array of processes during formation and maintenance of various organs including bone, cartilage, muscle, kidney, and blood vessels. BMPs and the related "growth and differentiation factors"
Takenobu, Katagiri, Tetsuro, Watabe
openaire +2 more sources
Heterodimeric BMP-2/7 antagonizes the inhibition of all-trans retinoic acid and promotes the osteoblastogenesis. [PDF]
PLoS ONE, 2013 OBJECTIVES: Hypervitaminosis A and alcoholism can result in a low mineral density and compromised regenerative capacity of bone, thus delaying implant osteointegration.
Wenjuan Bi +5 more
doaj +1 more source
Journal of Tissue Engineering, 2020 Limitation in cell sources for autologous cell therapy has been a recent focus in stem cell therapy and tissue engineering. Among various research advances, direct conversion, or transdifferentiation, is a notable and feasible strategy for the generation
Seung Hyun L Kim +8 more
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Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance.
PLoS ONE, 2012 We identified an amino acid change (p.G92E) in the Bone Morphogenetic Protein antagonist NOGGIN in a 22-month-old boy who presented with a unilateral brachydactyly type B phenotype. Brachydactyly type B is a skeletal malformation that has been associated
Julia Zimmer +6 more
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Bone Morphogenetic Protein-2 in Development and Bone Homeostasis
Journal of Developmental Biology, 2020 Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardiogenesis, neurogenesis, and ...
Daniel Halloran +2 more
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European Journal of Histochemistry, 2017 We investigated the expressions of bone morphogenetic protein-4 (BMP4) and its receptors, bone morphogenetic protein receptor IA (BMPRIA), bone morphogenetic protein receptor IB (BMPRIB) and bone morphogenetic protein receptor II (BMPRII) in the adult ...
Yuka Maruyama-Koide +3 more
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