Results 31 to 40 of about 76,730 (157)

Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease

Nature Communications, 2019
Multiple myeloma is a cancer of the bone marrow that can induce bone disease. Here, the authors profile the transcriptome of bone-lining cells and find a targetable role of bone morphogenetic protein (BMP) signalling in myeloma-induced bone ...
Sarah Gooding, Sam W. Z. Olechnowicz, Emma V. Morris, Andrew E. Armitage, Joao Arezes, Joe Frost, Emmanouela Repapi, James R. Edwards, Neil Ashley, Craig Waugh, Nicola Gray, Erik Martinez-Hackert, Pei Jin Lim, Sant-Rayn Pasricha, Helen Knowles, Adam J. Mead, Karthik Ramasamy, Hal Drakesmith, Claire M. Edwards   +18 more
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Bone morphogenetic proteins

Blood, 2009
Abstract BMP2 and BMP4 play crucial inductive roles during development. In this issue of Blood, Shao et al demonstrate that an intricate network of paracrine BMP2/4 signals also regulates angiogenesis—and will very likely interact with endocrine BMP cues during wound repair ...
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Bone morphogenetic protein 7 promotes resistance to immunotherapy

Nature Communications, 2020
The mechanisms underlying resistance to immunotherapy are still poorly understood. Here, the authors show that BMP7, a molecule part of the TGF-beta superfamily, suppresses proinflammatory antitumor responses and may represent a target for overcoming ...
Maria Angelica Cortez, Fatemeh Masrorpour, Cristina Ivan, Jie Zhang, Ahmed I. Younes, Yue Lu, Marcos R Estecio, Hampartsoum B. Barsoumian, Hari Menon, Mauricio da Silva Caetano, Rishab Ramapriyan, Jonathan E. Schoenhals, Xiaohong Wang, Ferdinandos Skoulidis, Mark D. Wasley, George Calin, Patrick Hwu, James W. Welsh   +17 more
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Bone morphogenetic protein 10 and atrial fibrillation

International Journal of Cardiology: Heart & Vasculature
Background: The association between bone morphogenetic protein 10 (BMP10) and atrial fibrillation (AF) has been widely investigated by observational studies, but their causal relationships remain inconclusive. Here, we aimed to evaluate the causal effect
Liang Liu, Yi Liang, Qi-Gang Lan, Jun-Zhang Chen, Rui Wang, Jing-Hong Zhao, Bo Liang   +6 more
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Addition of bone morphogenetic protein type 2 to ascorbate and β-glycerophosphate supplementation did not enhance osteogenic differentiation of human adipose-derived stem cells

Journal of Applied Oral Science, 2012
Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells.
Ariadne Cristiane Cabral Cruz, Mariana Lúcia Silva, Thiago Caon, Cláudia Maria Oliveira Simões   +3 more
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The Classic: Bone Morphogenetic Protein [PDF]

Clinical Orthopaedics and Related Research®, 2009
This Classic Article is a reprint of the original work by Marshall R. Urist and Basil S. Strates, Bone Morphogenetic Protein. An accompanying biographical sketch of Marshall R. Urist, MD is available at DOI 10.1007/s11999-009-1067-4; a second Classic Article is available at DOI 10.1007/s11999-009-1069-2; and a third Classic Article is available at DOI ...
Urist, Marshall R., Strates, Basil S.
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Combination of bone morphogenetic protein-2 plasmid DNA with chemokine [PDF]

European Cells & Materials, 2015
Bone morphogenetic protein-2 (BMP-2) gene delivery has shown to induce bone formation in vivo in cell-based tissue engineering. In addition, the chemoattractant stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) is known to recruit multipotent
F Wegman, MT Poldervaart, YJ van der Helm, FC Oner, WJ Dhert, J Alblas   +5 more
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Bone morphogenetic proteins: Signaling periodontal bone regeneration and repair

Journal of Pharmacy and Bioallied Sciences, 2016
Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal ...
G Sai Anusuya, M Kandasamy, S A Jacob Raja, S Sabarinathan, P Ravishankar, Balu Kandhasamy   +5 more
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Effect of modified compound calcium phosphate cement on the differentiation and osteogenesis of bone mesenchymal stem cells

Journal of Orthopaedic Surgery and Research, 2017
Background The aim of this study is to evaluate the effect of self-invented compound calcium phosphate cement upon the proliferation and osteogenesis of bone mesenchymal stem cells (BMSCs).
Jican Zeng, Jiazhong Lin, Guanfeng Yao, Kangmei Kong, Xinjia Wang   +4 more
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Efficacy of copolymer scaffolds delivering human demineralised dentine matrix for bone regeneration

Journal of Tissue Engineering, 2019
Poly(L-lactide-co-ε-caprolactone) scaffolds were functionalised by 10 or 20 µg/mL of human demineralised dentine matrix. Release kinetics up to 21 days and their osteogenic potential on human bone marrow stromal cells after 7 and 21 days were studied.
Arooj Munir, Anne Døskeland, Steven J Avery, Tiziana Fuoco, Samih Mohamed-Ahmed, Henning Lygre, Anna Finne-Wistrand, Alastair J Sloan, Rachel J Waddington, Kamal Mustafa, Salwa Suliman   +10 more
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