Bone Morphogenetic Protein-2 in Development and Bone Homeostasis [PDF]
Journal of Developmental Biology, 2020 Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the Transforming Growth Factor-Beta (TGF-β) superfamily. These proteins are essential to many developmental processes, including cardiogenesis, neurogenesis, and ...
Daniel Halloran +2 more
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Ectopic Laryngeal Ossification after Bone Morphogenetic Protein-2 [PDF]
Surgeries, 2021 We report two cases of ectopic bone formation in the head and neck following treatment with recombinant human bone morphogenetic protein-2 (rhBMP-2). Surgical pathologic data, laryngoscopy imaging, CT imaging, and patient medical history were obtained ...
Kirsten Wong +2 more
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Travmatologiâ i Ortopediâ Rossii, 2011 The influence of both, the composite material based on the protein-mineral components including the prolonged form of the recombinant human bone morphogenetic protein 2 (rhBMP-2) and the method of the titanium implant’s surface treatment, on the ...
M. Z. Fedorova +10 more
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Bone morphogenetic protein 2: heterologous expression and potential in bone regeneration
Actualidades Biológicas, 2021 Currently, bone morphogenetic protein 2 (BMP-2) is one of the two osteoinductive growth factors used in medical devices to promote bone formation. Typically, this protein is bought from commercial houses at high rates and in small quantities that are not
Andrea Mesa-Restrepo +2 more
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Bone morphogenetic protein-2-derived osteogenic peptide promotes bone regeneration via osteoblastogenesis [PDF]
Regenerative TherapyIntroduction: Bone morphogenetic protein (BMP)-2 plays a critical role in stimulating human mesenchymal stromal cells (hMSCs) differentiation, a key process in bone regeneration.
Jong-Bin Lee +6 more
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Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation [PDF]
Scientific Reports, 2018 Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced
M. Croes +6 more
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Accelerators of Osteogenesis by Recombinant Human Bone Morphogenetic Protein-2
Drug Target Insights, 2007 Bone morphogenetic protein (BMP) appears to be one of the most promising cytokine and for clinical use in reconstructive surgery for bony defects and augmentation.
Yasunori Okubo +2 more
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Focused Ultrasound-Mediated Release of Bone Morphogenetic Protein 2 from Hydrogels for Bone Regeneration [PDF]
GelsAn ultrasound-responsive hydrogel system was developed that provides on-demand release when stimulated by focused ultrasound (fUS). Diels–Alder cycloadducts crosslinked polyethylene glycol (PEG) hydrogels and underwent a retrograde Diels–Alder reaction ...
Tyus J. Yeingst +6 more
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Potentiating effect of AMD3100 on bone morphogenetic protein-2 induced bone regeneration [PDF]
Maxillofacial Plastic and Reconstructive SurgeryBackground AMD3100, a CXCR4 antagonist, is currently prescribed for activating the mobilization of hematopoietic stem cells. Recently, AMD3100 was shown to potentiate bone morphogenetic protein-2 (BMP-2)-induced bone formation by stimulating the ...
Gyu-Jo Shim +4 more
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Cell-permeable bone morphogenetic protein 2 facilitates bone regeneration by promoting osteogenesis [PDF]
Materials Today BioThe use of the FDA-approved osteoinductive growth factor BMP2 is widespread for bone regeneration. However, its clinical application has been hindered by limitations in cell permeability and a short half-life in circulation.
Mingu Kang +7 more
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