Results 11 to 20 of about 128,307 (303)

Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation [PDF]

Scientific Reports, 2018
Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced
M. Croes, M. C. Kruyt, W. M. Groen, K. M. A. van Dorenmalen, W. J. A. Dhert, F. C. Öner, J. Alblas   +6 more
doaj   +4 more sources

Recombinant Human Bone Morphogenetic Protein-2 and Collagen for Bone Regeneration

Journal of Biomedical Materials Research, 1998
The study reported describes a combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) and collagen (C) to regenerate bone. Unilateral critical-sized defects (CSDs) were prepared in radii of 32 skeletally mature New Zealand white rabbits.
Buck, David C, Hollinger, Jeffrey O, Joh, Seong-Pil, Schmitt, John M, Shannon, Robert, Wozney, John, Zegzula, H Daniel   +6 more
core   +4 more sources

Bone Morphogenetic Protein-2 Stimulates Runx2 Acetylation [PDF]

Journal of Biological Chemistry, 2006
Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway. Genetic analysis has revealed that Runx2 is degraded through a Smurf-mediated ubiquitination pathway, and its activity is inhibited by HDAC4.
Eun-Joo, Jeon, Kwang-Youl, Lee, Nam-Sook, Choi, Mi-Hye, Lee, Hyun-Nam, Kim, Yun-Hye, Jin, Hyun-Mo, Ryoo, Je-Yong, Choi, Minoru, Yoshida, Norikazu, Nishino, Byung-Chul, Oh, Kyeong-Sook, Lee, Yong Hee, Lee, Suk-Chul, Bae   +13 more
openaire   +2 more sources

Bone Morphogenetic Protein-2 Induces Proinflammatory Endothelial Phenotype [PDF]

The American Journal of Pathology, 2006
The transforming growth factor-beta superfamily member bone morphogenetic protein-2 (BMP-2) is up-regulated in atherosclerotic arteries; however, its effects on the endothelium are not well characterized. Using microdissected coronary arterial endothelial cells (CAECs) and cultured primary CAECs, we demonstrated endothelial mRNA expression of BMP-2 and
Anna, Csiszar, Mansoor, Ahmad, Kira E, Smith, Nazar, Labinskyy, Qun, Gao, Gabor, Kaley, John G, Edwards, Michael S, Wolin, Zoltan, Ungvari   +8 more
openaire   +2 more sources

Bone morphogenetic protein-2 influence on metabolic activity and proteoglycan synthesis by intervertebral disc cells

Acta Biomedica Scientifica, 2016
Modern therapeutic strategies for intervertebral disc repair mainly focus on targeting molecular pathways of extracellular matrix degeneration. Anabolic strategies for regeneration are aimed to increase production of major extracellular molecules ...
L. A. Bardonova, E. G. Belykh, V. A. Byvaltsev   +2 more
doaj   +1 more source

Differences in the pattern and regulation of mineral deposition in human cell lines of osteogenic and non-osteogenic origin [PDF]

, 2011
Bone marrow-derived mesenchymal stem cells (MSCs) are widely used as a cellular model of bone formation, and can mineralize in vitro in response to osteogenic medium (OM).
Alexander J. Blake, Amatschek S., Andrews P.W., Andrews P.W., Beresford J.N., Blumberg P., Boland G.M., Bonewald L.F., Boskey A.L., Boskey A.L., Boylan M.O., Briggs T., Bruder S.P., Buttery L.D., Cancedda R., Chadalavada R.S., Cheng S.L., Clover J., Cristina Tufarelli, Declercq H.A., Draper J.S., Duran C., Eijken M., Gang E.J., Gentleman E., Gey G.O., Graham F.L., Gregory C.A., Halleux C., Hassan Rashidi, Hui M., Iba K., Ilse G., Izbicka E., Jackson L., Jaiswal N., Jaiswal R.K., Jorgensen N.R., Kasten P., Khosla S., Khouja H.I., Kimelman N., Kniss D.A., Kochanowska I.E., Kochanowska I.E., Koeneman K.S., Leigh Jackson, Lin D.L., Liu F., Louise France, Maeda S., Mareschi K., Marie P.J., Markovic M., McCulloch C.A., Morgan M.P., Okamoto T., Ostrowski K., Pal R., Palmieri A., Park K.W., Pautke C., Pera M.F., Peter S.J., Pittenger M.F., Poliard A., Rago R., Rodríguez J.P., Russell R.G., Seib F.P., Shukunami C., Simoes P.D., Song I.H., Sottile V., Sottile V., Spandan Kalra, Spiropoulos A., Stephanie Strohbuecker, Tang N., Tataria M., Tenenbaum H.C., Thomas P., Tremoleda J.L., Virginie Sottile, Yu P.B., Zayzafoon M., zur Nieden N.I.   +86 more
core   +1 more source

Addition of bone morphogenetic protein type 2 to ascorbate and β-glycerophosphate supplementation did not enhance osteogenic differentiation of human adipose-derived stem cells

Journal of Applied Oral Science, 2012
Bone morphogenetic protein type 2 (BMP-2) is a potent local factor, which promotes bone formation and has been used as an osteogenic supplement for mesenchymal stem cells.
Ariadne Cristiane Cabral Cruz, Mariana Lúcia Silva, Thiago Caon, Cláudia Maria Oliveira Simões   +3 more
doaj   +1 more source

Bone Morphogenetic Protein as Bone Additive around Dental Implant and its Impact on Osseointegration: a Systematic Review [PDF]

Journal of Dentistry, 2022
Statement of the Problem: Bone morphogenetic protein (BMP), a potential osteoinductive agent, was systematically reviewed for merits and demerits when used as a bone additive that was intervened during the surgical phase of dental implant placement; and ...
Fathima Banu Raza , Sivakumar Vijayaragavalu , Anand Kumar Vaidyanathan   +2 more
doaj   +1 more source

Bone morphogenetic protein-2 and bone therapy: successes and pitfalls [PDF]

Journal of Pharmacy and Pharmacology, 2016
Abstract Objectives Bone morphogenetic proteins (BMPs), more specifically BMP-2, are being increasingly used in orthopaedic surgery due to advanced research into osteoinductive factors that may enhance and improve bone therapy.
Poon, B., Kha, T., Tran, S., Dass, Crispin   +3 more
openaire   +3 more sources

Effects of bioactive glass S53P4 or beta-tricalcium phosphate and bone morphogenetic protein-2 and bone morphogenetic protein-7 on osteogenic differentiation of human adipose stem cells

Journal of Tissue Engineering, 2012
The effects of bioactive glass S53P4 or beta-tricalcium phosphate; and bone morphogenetic proteins bone morphogenetic protein-2, bone morphogenetic protein-7, or bone morphogenetic protein-2 + 7 on osteogenic differentiation of human adipose stem cells ...
Martin Waselau, Mimmi Patrikoski, Miia Juntunen, Kasperi Kujala, Minna Kääriäinen, Hannu Kuokkanen, George K Sándor, Outi Vapaavuori, Riitta Suuronen, Bettina Mannerström, Brigitte von Rechenberg, Susanna Miettinen   +11 more
doaj   +1 more source