Results 41 to 50 of about 27,645,133 (294)
, 2009 Background: Tissue-engineered solutions for promoting the tendon graft incorporation within the bone tunnel appear to be promising. Hypothesis: To determine the feasibility that conjugation of hyaluronic acid-tethered bone morphogenetic protein-2 can be ...
CHEN, CHIH-HWA;LIU, HSIA-WEI;TSAI, CHING-LIN;YU, CHUNG-MING;HSIUE, GING-HO +1 more
core +1 more source
Endothelialized tissue engineered 3D-construct for bone repair [PDF]
, 2005 One of the main problems arising when implanting a graft into a large bone gap is its insufficient vascularization in the central region. This results in impaired bone healing and often leads to necrosis in the graft.
Meury, Thomas
core +1 more source
Advanced Healthcare Materials, EarlyView.Efficient recovery from traumatic or degenerative diseases is a great challenge, even after all the advancements in bone and cartilage regeneration. Machine learning (ML) algorithms have presented opportunities to enhance these aspects by accurately analyzing imaging data.
Maryam Kamaei +9 more
wiley +1 more source
Biogran Grafting in Rat Tibia Defects - A Model of High Bone Metabolism Site [PDF]
Brazilian Archives of Biology and TechnologyWe investigated the Biogran on bone repair and metabolism at several time-intervals upon grafting into rat tibia artificial defects. The biomaterial was thoroughly characterized in vitro, and its dissolution behavior upon immersion was assessed in ...
Luiza de Almeida Queiroz Ferreira +12 more
doaj +1 more source
Chitosan scaffolds containing calcium phosphate salts and rhBMP-2: in vitro and in vivo testing for bone tissue regeneration. [PDF]
PLoS ONE, 2014 Numerous strategies that are currently used to regenerate bone depend on employing biocompatible materials exhibiting a scaffold structure. These scaffolds can be manufactured containing particular active compounds, such as hydroxyapatite precursors and ...
Rodrigo Guzmán +7 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett +7 more
wiley +1 more source
Stimulation of Bone Healing by Sustained Bone Morphogenetic Protein 2 (BMP-2) Delivery [PDF]
International Journal of Molecular Sciences, 2014 The aim of the study was to investigate the effect of a sustained release of bone morphogenetic protein2 (BMP-2) incorporated in a polymeric implant coating on bone healing. In vitro analysis revealed a sustained, but incomplete BMP-2 release until Day 42. For the in vivo study, the rat tibia osteotomy was stabilized either with control or BMP-2 coated
Mirja Faßbender +4 more
openaire +2 more sources
Bone substitute effect on vascularization and bone remodeling after application of phVEGF165 transfected BMSC [PDF]
, 2012 VEGF (vascular endothelial growth factor) promotes vascularization and remodeling of bone substitutes. The aim of this study was to examine the effect of distinct resorbable ceramic carriers on bone forming capacities of VEGF transfected bone marrow ...
Beverungen, Mirjam +11 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Dynamic compression enhances mesenchymal stromal cell proliferation in nonwoven PET scaffolds under chondrogenic differentiation conditions and triggers mechanosensitive transcriptional programs associated with extracellular matrix remodeling. These findings highlight the potential of mechanically stimulated PET scaffolds as a promising platform for ...
Graciosa Quelhas Teixeira +8 more
wiley +1 more source
Recombinant human bone morphogenetic protein-2 and collagen for bone regeneration
Journal of Biomedical Materials Research, 1998 The study reported describes a combination of recombinant human bone morphogenetic protein-2 (rhBMP-2) and collagen (C) to regenerate bone. Unilateral critical-sized defects (CSDs) were prepared in radii of 32 skeletally mature New Zealand white rabbits. Rabbits were divided evenly among four treatments: autograft, absorbable C (Helistat), 35 microg of
Hollinger, Jeffrey O +6 more
openaire +3 more sources