Results 51 to 60 of about 27,645,133 (294)

Matrix GLA Protein, a Regulatory Protein for Bone Morphogenetic Protein-2 [PDF]

Journal of Biological Chemistry, 2002
Matrix GLA protein (MGP) has been identified as a calcification inhibitor in cartilage and vasculature. Part of this effect may be attributed to its influence on osteoinductive activity of bone morphogenetic protein-2 (BMP-2). To detect binding between MGP and BMP-2, we performed immunoprecipitation using MGP and BMP-2 tagged with FLAG and c-Myc.
Amina F, Zebboudj, Minori, Imura, Kristina, Boström   +2 more
openaire   +2 more sources

The role of skeletal tissue remodeling markers in the patho-genesis of implant-associated inflammation after primary knee arthroplasty [PDF]

Саратовский научно-медицинский журнал, 2018
Aim: to reveal certain mechanisms of the pathogenesis of implant-associated inflammation by the level of resorption and bone tissue genesis markers in patients who underwent primary knee arthroplasty. Material and Methods.
Galashina Е.А., Bondarenko A.S., Ulyanov V.Yu., Klimov S.S.   +3 more
doaj  

Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development [PDF]

, 2008
Background: Adrenal chromaffin cells and sympathetic neurons both originate from the neural crest, yet signals that trigger chromaffin development remain elusive.
Huber, Katrin, Halbach Oliver, Kalcheim Chaya, Krispin, S., Krispin Shlomi, Huber, K., Oliver von Bohlen und Halbach, Hermann Rohrer, Unsicker, K., Rohrer, H., Aylin Franke, Shlomi Krispin, Franke Aylin, Ernsberger, U., Unsicker, Klaus, Brühl, Barbara, Huber Katrin, Schober Andreas, Ernsberger Uwe, Chaya Kalcheim, Barbara Brühl, Klaus Unsicker, von Bohlen und Halbach, O., Franke, Aylin, Brühl Barbara, Bohlen und Halbach, Oliver von, Schober, A., Ernsberger, Uwe, Kalcheim, Chaya, Rohrer, Hermann, Rohrer Hermann, Andreas Schober, Schober, Andreas, Krispin, Shlomi, Unsicker Klaus, Brühl, B., Kalcheim, C., Franke, A., Katrin Huber, Uwe Ernsberger   +39 more
core   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

Cell-permeable bone morphogenetic protein 2 facilitates bone regeneration by promoting osteogenesis

Materials Today Bio
The use of the FDA-approved osteoinductive growth factor BMP2 is widespread for bone regeneration. However, its clinical application has been hindered by limitations in cell permeability and a short half-life in circulation.
Mingu Kang, Seokwon Lee, Jong-pil Seo, Eun-bee Lee, Daye Ahn, Jisoo Shin, Young-Ki Paik, Daewoong Jo   +7 more
doaj   +1 more source

Accelerators of Osteogenesis by Recombinant Human Bone Morphogenetic Protein-2

Drug Target Insights, 2007
Bone morphogenetic protein (BMP) appears to be one of the most promising cytokine and for clinical use in reconstructive surgery for bony defects and augmentation.
Yasunori Okubo, Kenji Kusumoto, Kazuhisa Bessho   +2 more
doaj   +2 more sources

3D‐Printed Corneal Substitutes: Materials, Fabrication, and Preclinical Progress

Advanced Materials Technologies, EarlyView.
Successful clinical translation of 3D‐printed corneal substitutes relies on the interplay between the bioink properties, cellular component, and the fabrication process. These factors influence the critical properties of the construct, including optical transparency, mechanical stability, suture retention, that ultimately govern long‐term stromal ...
Shadi Moshayedi, Ashley Vazquez, Alexander J. Choi, Dimitrios Karamichos, Jayoung Kim   +4 more
wiley   +1 more source

Identification of a bone morphogenetic protein type 2 receptor neutralizing antibody

BMC Research Notes, 2019
Objective The bone morphogenetic protein (BMP) signaling pathway comprises the largest subdivision of the transforming growth factor (TGFβ) superfamily.
Ruthann E. Gorrell, Madeline H. Totten, Laura J. Schoerning, Jordan B. Newby, Logan J. Geyman, Warren G. Lawless, Julia M. Hum, Jonathan W. Lowery   +7 more
doaj   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

A Pentaradial and Bilateral Combined Photoreception System in the Sea Cucumber is Mediated by a Blue Light‐Sensitive R‐Opsin

Advanced Science, EarlyView.
The sea cucumber Holothuria leucospilota detects blue and adjacent wavelengths of light via an r‐opsin with a maximum absorption at 459 nm. In the oral tentacles, papillae, and tube feet, distinct light‐sensing structures with specialized morphologies are formed, constituting a unique pentaradial and bilateral combined photoreception system.
Jiasheng Huang, Chunhua Ren, Zhou Qin, Yimeng Cui, Bingbing Zhang, Peng Luo, Xuan Wang, Yaoqi Xie, Xin Zhang, Aifen Yan, Yang Zhang, Dingding Fan, Yang Liu, Wenjie Pan, Xiao Jiang, Lihong Yuan, Haipeng Qin, David M. Irwin, Chaoqun Hu, Yang Liu, Ting Chen   +20 more
wiley   +1 more source