Results 31 to 40 of about 27,645,133 (294)

Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/b-tricalcium phosphate porous ceramics [PDF]

, 2009
The association of bone morphogenetic proteins (BMPs) with calcium phosphate bioceramics is known to confer them osteoinductive properties. The aim of this study was to evaluate the surface properties, especially regarding recombinant human BMP-2 (rhBMP-
Christèle Combes, Briand-Mésange, Fabienne, Fabienne Briand‐Mésange, Combes, Christèle, Gonçalvès, Stéphane, Drouet, Christophe, Stéphane Gonçalvès, Fourmy, Daniel, Swider, Pascal, Rey, Christian, Hélène Autefage, Christophe Drouet, Salles, Jean-Pierre, Sophie Cazalbou, Jean‐Pierre Salles, Cazalbou, Sophie, Pascal Swider, Christian Rey, Autefage, Hélène, Daniel Fourmy   +19 more
core   +1 more source

Sustained Release of Bone Morphogenetic Protein 2 via Coacervate

Foot & Ankle Orthopaedics, 2016
Category: Basic Sciences/Biologics Introduction/Purpose: Currently, there is no cure for osteoarthritis (OA) with treatment aimed at symptom relief and improved function.
MaCalus V. Hogan MD, Justin H. Hicks, Biomedical Engineering, Jorge L. Rocha BA, Hongshuai Li MD, PhD, Yadong Wang, Johnny Huard   +6 more
doaj   +1 more source

Kielin/chordin‐like protein enhances induction of osteoblast differentiation by Bone Morphogenetic Protein‐2

FEBS Open Bio, 2023
Bone morphogenetic proteins (BMPs) play a key role in embryonic differentiation for osteoblast and bone formation. Kielin/chordin‐like protein (Kcp) is known to enhance the effects of BMP signaling.
Kei Nagasaki, Atsushi Yamada, Kiyohito Sasa, Ryutaro Kamijo   +3 more
doaj   +1 more source

BMP4 Induces Cardiomyocyte Hypertrophy Through the Activation of ERK 1/2 Signaling Pathway in H9c2 Cells [PDF]

Brazilian Archives of Biology and Technology
Bone morphogenetic protein-4 (BMP4) is a member of the bone morphogenetic protein family which plays an important role in bone formation, inflammation and cardiac hypertrophy.
Yu Yuan, Yezheng Tao, Yongzhi Deng, Qunhui Ye, Bin Lin, Lin Wu   +5 more
doaj   +2 more sources

Preparation of Recombinant Bone Morphogenetic Protein 2 at Laboratory Scale

Regeneration, Reconstruction & Restoration, 2016
Introduction: Millions cases of bone fracture are reported annually worldwide. The conventional methods for the repair often fail. The complications of using routine methods include stimulation of bone repair which should be performed without infection ...
Mahmoud Kazemi, Ali Hassani, Mojgan Bandehpour, Bahram Kazemi   +3 more
doaj   +1 more source

Combination of bone morphogenetic protein-2 plasmid DNA with chemokine [PDF]

European Cells & Materials, 2015
Bone morphogenetic protein-2 (BMP-2) gene delivery has shown to induce bone formation in vivo in cell-based tissue engineering. In addition, the chemoattractant stromal cell-derived factor-1α (SDF-1α, also known as CXCL12) is known to recruit multipotent
F Wegman, MT Poldervaart, YJ van der Helm, FC Oner, WJ Dhert, J Alblas   +5 more
doaj   +1 more source

Development, In-Vitro Characterization and In-Vivo Osteoinductive Efficacy of a Novel Biomimetically-Precipitated Nanocrystalline Calcium Phosphate With Internally-Incorporated Bone Morphogenetic Protein-2

Frontiers in Bioengineering and Biotechnology, 2022
The repair of large-volume bone defects (LVBDs) remains a great challenge in the fields of orthopedics and maxillofacial surgery. Most clinically available bone-defect-filling materials lack proper degradability and efficient osteoinductivity.
Gaoli Xu, Gaoli Xu, Chenxi Shen, Chenxi Shen, Haiyan Lin, Haiyan Lin, Jian Zhou, Ting Wang, Ben Wan, Ben Wan, Munerah Binshabaib, Tymour Forouzanfar, Guochao Xu, Nawal Alharbi, Gang Wu, Gang Wu   +15 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

High-Density Lipoproteins from Coronary Artery Disease and Aortic Valve Stenosis Patients Differentially Regulate Gene Expression in a Model of Cardiac Adipocytes

Cells
Previous reports have described a statistical association between high-density lipoproteins (HDL) subclasses and the expression of genes coding for pro-calcifying proteins in the epicardial adipose tissue of patients with coronary artery disease (CAD ...
María Luna-Luna, Araceli Páez, Felipe Massó, Rebeca López-Marure, Jorge Moisés Zozaya-García, Ariana Vargas-Castillo, Daniel Gómez-Pineda, Armando R. Tovar, Jonathan J. Magaña, José Manuel Fragoso, Margarita Gutiérrez-Saldaña, Zuriel Téllez-Osorio, Óscar Pérez-Méndez   +12 more
doaj   +1 more source

Interleukin 17 enhances bone morphogenetic protein-2-induced ectopic bone formation

Scientific Reports, 2018
Interleukin 17 (IL-17) stimulates the osteogenic differentiation of progenitor cells in vitro through a synergy with bone morphogenetic protein (BMP)-2. This study investigates whether the diverse responses mediated by IL-17 in vivo also lead to enhanced
M. Croes, M. C. Kruyt, W. M. Groen, K. M. A. van Dorenmalen, W. J. A. Dhert, F. C. Öner, J. Alblas   +6 more
doaj   +1 more source