Recombinant human bone morphogenetic protein-2 in the treatment of bone fractures
Biologics: Targets & Therapy, 2008 Neil Ghodadra, Kern SinghDepartment of Orthopedic Surgery, Rush University Medical Center, Chicago, Illinois, USAAbstract: Over one million fractures occur per year in the US and are associated with impaired healing increasing patient morbidity, stress ...
Neil Ghodadra, Kern Singh
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The effect of bone morphogenetic protein-2 on osteosarcoma metastasis. [PDF]
PLoS ONE, 2017 PURPOSE:Bone Morphogenetic Protein-2 (BMP-2) may offer the potential to enhance allograft-host osseous union in limb-salvage surgery following osteosarcoma resection.
Jonathan Gill +11 more
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Limitations of bone formation in oral implantology: inhibition of osteoblast functions by gingival tissues [PDF]
, 2010 PhDClinical observation suggest that bone formation is influenced by the environmental niche where it takes place and specifically that soft connective tissues may inhibit the bone healing process.
Al-Masri, Maher
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Bone morphogenetic protein-2 and bone therapy: successes and pitfalls [PDF]
Journal of Pharmacy and Pharmacology, 2016 Abstract Objectives Bone morphogenetic proteins (BMPs), more specifically BMP-2, are being increasingly used in orthopaedic surgery due to advanced research into osteoinductive factors that may enhance and improve bone therapy.
Poon, B. +3 more
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Novel fluorescent probes for analysis of protein interactions under truly physiological conditions with real medical devices [PDF]
, 2012 PhDProtein adsorption under physiological conditions was recognised to be the key step in the modulation of biological responses between materials and an osseous environment.
Mafina, Marc-Krystelle
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Bone Morphogenetic Protein-2 Stimulates Runx2 Acetylation [PDF]
Journal of Biological Chemistry, 2006 Runx2/Cbfa1/Pebp2aA is a global regulator of osteogenesis and is crucial for regulating the expression of bone-specific genes. Runx2 is a major target of the bone morphogenetic protein (BMP) pathway. Genetic analysis has revealed that Runx2 is degraded through a Smurf-mediated ubiquitination pathway, and its activity is inhibited by HDAC4.
Eun-Joo, Jeon +13 more
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Acta Biomedica Scientifica, 2016 Modern therapeutic strategies for intervertebral disc repair mainly focus on targeting molecular pathways of extracellular matrix degeneration. Anabolic strategies for regeneration are aimed to increase production of major extracellular molecules ...
L. A. Bardonova +2 more
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USP15 targets ALK3/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling [PDF]
, 2014 Protein kinase ALK3/BMPR1A mediates bone morphogenetic protein (BMP) signalling through phosphorylation and activation of SMADs 1/5/8. SMAD6, a transcriptional target of BMP, negatively regulates the BMP pathway by recruiting E3 ubiquitin ligases and ...
Bruce, David +11 more
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Regulation of Phosphatase Homologue of Tensin Protein Expression by Bone Morphogenetic Proteins in Prostate Epithelial Cells [PDF]
, 2010 Phosphatase homologue of tensin (PTEN) is the key endogenous inhibitor of phosphoinositide signaling and is the most commonly mutated gene in human prostate cancer.
Travis Jerde +4 more
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Protein associated with SMAD1 (PAWS1/FAM83G) is a substrate for type I bone morphogenetic protein receptors and modulates bone morphogenetic protein signalling [PDF]
, 2014 Bone morphogenetic proteins (BMPs) control multiple cellular processes in embryos and adult tissues. BMPs signal through the activation of type I BMP receptor kinases, which then phosphorylate SMADs 1/5/8.
Smith, James C. +15 more
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