Results 251 to 260 of about 128,307 (303)

Surgical Reconstruction of Canine Nonunion Fractures Using Bone Morphogenetic Protein-2-loaded Alginate Microbeads and Bone Allografts. [PDF]

In Vivo
Lee S, Kang BJ.
europepmc   +1 more source

Glycinamide Facilitates Nanocomplex Formation and Functions Synergistically with Bone Morphogenetic Protein 2 to Promote Osteoblast Differentiation In Vitro and Bone Regeneration in a Mouse Calvarial Defect Model. [PDF]

Tissue Eng Regen Med
Nam SH, Kim JA, Lim S, Lee SJ, Kim CH, Bae JS, Boo YC, Kim YJ, Park EK.   +8 more
europepmc   +1 more source

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Bone Morphogenetic Protein-2

Clinical Orthopaedics and Related Research, 1996
Bone morphogenetic protein-2 is a low molecular weight glycoprotein, classified as a morphogen. The sine qua non of bone morphogenetic protein is consistently reproducible induction of bone development in heterotopic sites. Bone morphogenetic proteins belong to the expanding transforming growth factor-beta superfamily.
E H, Riley, J M, Lane, M R, Urist, K M, Lyons, J R, Lieberman   +4 more
openaire   +2 more sources

Bone Morphogenetic Protein-2 Plasmid DNA as a Substitute for Bone Morphogenetic Protein-2 Protein in Bone Tissue Engineering

Tissue Engineering Part A, 2013
Bone regeneration is one of the focus points in the field of regenerative medicine. A well-known stimulus of bone formation is bone morphogenetic protein-2 (BMP-2), which has already been extensively used in clinical applications. However, due to a short half-life, supraphysiological doses are applied resulting in severe side effects such as ectopic ...
Wegman, Fiona, van der Helm, Yvonne, Öner, F Cumhur, Dhert, Wouter J A, Alblas, Jacqueline   +4 more
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Bone Morphogenetic Protein‐2 Antagonizes Bone Morphogenetic Protein‐4 Induced Cardiomyocyte Hypertrophy and Apoptosis

Journal of Cellular Physiology, 2014
Our previous work showed that the expression of bone morphogenetic protein‐4 (BMP4) was up‐regulated in pathological cardiac hypertrophy models and BMP4 induced cardiomyocyte hypertrophy and apoptosis. Bone morphogenetic protein‐2 (BMP2) and BMP4 share greater than 80% amino acid homology and there exists an interaction between BMP2 and BMP4, so the ...
Jing, Lu, Bo, Sun, Rong, Huo, Yu-Chun, Wang, Di, Yang, Yue, Xing, Xiao-Lin, Xiao, Xin, Xie, De-Li, Dong   +8 more
openaire   +2 more sources

Repair of Bone Allograft Fracture Using Bone Morphogenetic Protein-2

Clinical Orthopaedics and Related Research, 2002
Long-term clinical data have shown that reconstruction using bone allografts provide adequate function after extensive tumor surgery. Complications such as nonunion of allograft-host interface, infection, and allograft fracture often require major revision surgeries.
Francis Young-In, Lee, Stephen, Storer, Eric J, Hazan, Mark C, Gebhardt, Henry J, Mankin   +4 more
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Bone Morphogenetic Protein 2 Coordinates Early Tooth Mineralization

Journal of Dental Research, 2018
Formation of highly organized dental hard tissues is a complex process involving sequential and ordered deposition of an extracellular scaffold, followed by its mineralization. Odontoblast and ameloblast differentiation involves reciprocal and sequential epithelial-mesenchymal interactions.
Z. Malik, M. Alexiou, B. Hallgrimsson, A.N. Economides, H.U. Luder, D. Graf   +5 more
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Bone Morphogenetic Protein 2 Therapy for Craniofacial Surgery

Journal of Craniofacial Surgery, 2008
Between 2 and 10 years of age, the developing craniofacial skeleton poses a significant reconstructive challenge. Local autogenous bone is largely unavailable, distant bone grafts are fraught with significant morbidity and limited yield, and alloplastic materials are incompatible with the growing calvarium and facial skeleton.
Darren M, Smith, Gregory M, Cooper, Mark P, Mooney, Kacey G, Marra, Joseph E, Losee   +4 more
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RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2

The Journal of Bone and Joint Surgery-American Volume, 2003
It has been several decades since Marshall Urist's discovery of osteoinductive activity within demineralized bone protein extracts. Initially described in Science in 1965 1, Dr. Urist's remarkable discovery, an unexpected byproduct of intended research on the competitive binding of radionucleotides during bone mineralization, suggested that ...
Harvinder S, Sandhu, Safdar N, Khan
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Potential of Recombinant Human Bone Morphogenetic Protein-2 in Bone Regeneration

Implant Dentistry, 1999
Recombinant human bone morphogenetic protein (rhBMP-2) has been used as a bone substitute. This article describes the rhBMP-2 structure, mechanisms of action, carriers, advantages, safety, and recent clinical studies relevant to dentistry.
E, Barboza, A, Caúla, F, Machado
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