Results 101 to 110 of about 178,667 (323)

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Biological Behavior of Bioactive Glasses SinGlass (45S5) and SinGlass High (F18) in the Repair of Critical Bone Defects

Biomolecules
This study evaluated the osteogenic potential of the bioactive glasses SinGlass (45S5) and SinGlass High (F18) in regenerating critical bone defects in rat calvaria.
Dayane Maria Braz Nogueira, Marcelie Priscila de Oliveira Rosso, Paulo Sérgio da Silva Santos, Manoel Damião Sousa-Neto, Alice Corrêa Silva-Sousa, Cleverson Teixeira Soares, Carlos Henrique Bertoni Reis, Jéssica de Oliveira Rossi, Cleuber Rodrigo de Souza Bueno, Daniela Vieira Buchaim, Rogério Leone Buchaim, Mariana Schutzer Ragghianti Zangrando   +11 more
doaj   +1 more source

Bone growth following demineralized bone matrix implantation requires angiogenesis [PDF]

, 2016
Angiogenesis is required for endochondral ossification during development and fracture healing; however the exact mechanisms and temporal relationship between the two processes remains unclear.
Lam, Stephanie
core  

Bmp induces osteoblast differentiation through both Smad4 and mTORC1 signaling [PDF]

, 2017
The bone morphogenetic protein (Bmp) family of secreted molecules has been extensively studied in the context of osteoblast differentiation. However, the intracellular signaling cascades that mediate the osteoblastogenic function of Bmp have not been ...
Karner, Courtney M, Lee, Seung-Yon, Long, Fanxin   +2 more
core   +2 more sources

Start, Stop, Rewind, Repeat—Cyclic Exposure of Adipose Stromal Cells‐derived Cartilage Organoids to Chondrogenic and Proliferative Cues to Achieve Scaled‐up and Customizable Bone Formation by Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
This study exploits the plasticity of ASCs‐derived cartilage organoids which generate a perichondrial layer of MSCs when exposed to cyclic chondrogenic/proliferative cues. Using these organoids as building blocks, we develop (i) Phalange Shaped Tissue Engineered Cartilage (Pa‐TECs), recapitulating endochondral ossification suitable for the treatment of
Pablo Pfister, Emilien Lhospice, Andrés García‐García, Robert Paillaud, Sebastian Jung, Romain Schaller, Elisabeth A. Kappos, Claude Jaquiéry, Tarek Ismail, Dirk J. Schaefer, Michael de Wild, Ivan Martin, Alexandre Kaempfen, Arnaud Scherberich, Adrien Moya   +14 more
wiley   +1 more source

Bone Morphogenetic Protein-4 Influences Neural Differentiation of Induced Mouse Mesenchymal Stem Cells [PDF]

Cell Journal, 2011
Objective: Members of the transforming growth factor-β superfamily, including bone morphogeneticprotein 4 (BMP4), have been implicated as regulators of neural differentiation.The aim of this study was to establish whether BMP4 could influence neuronal ...
Maryam Rezaei, Khadijeh Karbalaie, Somayeh Tanhaie, Hossein Madani, Mohammad Hossein Nasr Esfahani, Hossein Baharvand   +5 more
doaj  

Role of noncoding RNA in vascular remodelling [PDF]

, 2016
Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H., Bradshaw, Angela C., Deng, Lin   +2 more
core   +1 more source

Role of Bone morphogenetic protein 4 in zebrafish semicircular canal development [PDF]

Development, Growth & Differentiation, 2007
Bone morphogenetic proteins (BMPs) are known to play roles in inner ear development of higher vertebrates. In zebrafish, there are several reports showing that members of the BMP family are expressed in the otic vesicle. We have isolated a novel zebrafish mutant gallery, which affects the development of the semicircular canal.
Yasuhiro, Omata, Yasuhiro, Nojima, Satomi, Nakayama, Hitoshi, Okamoto, Harukazu, Nakamura, Jun-ichi, Funahashi   +5 more
openaire   +2 more sources

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source

The WNT Inhibitor Dickkopf 1 and Bone Morphogenetic Protein 4 Rescue Adipogenesis in Hypertrophic Obesity in Humans

Diabetes, 2012
Overweight characterized by inappropriate expansion of adipose cells (hypertrophic obesity) is associated with the metabolic syndrome and is caused by an inability to recruit and differentiate new precursor cells.
B. Gustafson, U. Smith
semanticscholar   +1 more source