Results 121 to 130 of about 75,633 (154)

Involvement of bone morphogenetic protein-4 and bone morphogenetic protein-7 in the differentiation of the adrenergic phenotype in developing sympathetic neurons

Development, 1996
ABSTRACT The neurotransmitter phenotype of sympathetic neurons is specified by interactions with the surrounding embryonic tissues. Adrenergic differentiation is elicited early during development in the vicinity of notochord and dorsal aorta and the importance of axial midline tissues for adrenergic differentiation has been well ...
E, Reissmann, U, Ernsberger, P H, Francis-West, D, Rueger, P M, Brickell, H, Rohrer   +5 more
openaire   +2 more sources

Bone Morphogenetic Protein-4 Regulation in Fibrodysplasia Ossificans Progressiva

Clinical Orthopaedics and Related Research, 2003
Fibrodysplasia ossificans progressiva is a rare genetic disorder in which connective tissues are replaced with heterotopic bone through an endochondral process. Bone morphogenetic protein-4 messenger ribonucleic acid and protein levels are elevated in the cells of patients with fibrodysplasia ossificans progressiva, but the molecular mechanism of this ...
Elizabeth A, Olmsted, Frederick S, Kaplan, Eileen M, Shore   +2 more
openaire   +2 more sources

Chromosomal Assignment of the Human Gene for Bone Morphogenetic Protein 4

Clinical Orthopaedics and Related Research, 1993
Bone morphogenetic proteins (BMP) are the only known biologic factors capable of inducing endochondral ossification at an extraskeletal site. Seven members of the BMP family have been identified thus far and are involved in osteoinduction and morphogenesis.
J A, Tabas, G V, Hahn, R B, Cohen, H N, Seaunez, W S, Modi, J M, Wozney, M, Zasloff, F S, Kaplan   +7 more
openaire   +2 more sources

Regulating the Role of Bone Morphogenetic Protein 4 in Tooth Bioengineering

Journal of Oral and Maxillofacial Surgery, 2007
Culture of the whole organ and regulation of its development using biologic and engineering principles can be used to produce structures and organs for reconstructing defects. The application of these bioengineering approaches in artificial tooth development may be the alternative way to replace missing dentition.For the artificial bioengineering of a ...
Il-Hyuk, Chung, Pill-Hoon, Choung, Hyun-Jeong, Ryu, Young-Ho, Kang, Han-Wool, Choung, Jong-Hoon, Chung, Yun-Hoon, Choung   +6 more
openaire   +2 more sources

Ectopic bone formation by electroporatic transfer of bone morphogenetic protein-4 gene

Bone, 2002
Orthopedic surgeons have long awaited the clinical application of bone morphogenetic proteins (BMPs) for bone regeneration. However, such possible applications involving proteins or genes transferred with virus vectors have encountered many problems, including high cost, immunological reactions, viral infection, etc.
K N, Kishimoto, Y, Watanabe, H, Nakamura, S, Kokubun   +3 more
openaire   +2 more sources

Use of Monoclonal Antibody to Detect Bone Morphogenetic Protein-4 (BMP-4)

Bone, 1995
A monoclonal antibody that reacts with murine and human bone morphogenetic protein-4 (BMP-4) has been developed using recombinant BMP-4 as an immunogen. The antibody that bound most tightly to recombinant murine (rm)BMP-4 was selected, subcloned, and characterized.
K, Masuhara, T, Nakase, S, Suzuki, K, Takaoka, M, Matsui, H C, Anderson   +5 more
openaire   +2 more sources

Potent Ectopic Bone-Inducing Activity of Bone Morphogenetic Protein-4/7 Heterodimer

Biochemical and Biophysical Research Communications, 1995
We have purified and characterized recombinant Xenopus bone morphogenetic proteins (xBMPs): homodimers of xBMP-4, 7 and heterodimers (xBMP-4/7) produced by a baculovirus expression system. Highly purified xBMPs had homogeneous NH2-termini predicted from a consensus motif, Arg-X-X-Arg, while they possessed diverse sugar chains.
A, Aono, M, Hazama, K, Notoya, S, Taketomi, H, Yamasaki, R, Tsukuda, S, Sasaki, Y, Fujisawa   +7 more
openaire   +2 more sources

Assay of Bone Morphogenetic Protein-2, -4, and -7 in Human Demineralized Bone Matrix

Journal of Craniofacial Surgery, 2006
Demineralized bone matrix (DBM) is a widely used bone graft material that derives its osteoinductive potential from matrix-associated bone morphogenetic proteins (BMPs). Prior investigations have shown that the osteoinductive potential can vary widely, with influence from both donor and processing sources.
William S, Pietrzak, Jennifer, Woodell-May, Nicholas, McDonald   +2 more
openaire   +2 more sources

Regulation of the promoters for the human bone morphogenetic protein 2 and 4 genes

Gene, 2000
The bone morphogenetic proteins 2 and 4 are known to be important in bone formation and are expressed in both the developing and adult mammalian bone. Understanding the regulation of these genes in osteoblasts may yield methods by which we can control expression to induce bone formation.
L M, Helvering, R L, Sharp, X, Ou, A G, Geiser   +3 more
openaire   +2 more sources

Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart

Life Sciences, 2014
Heart failure is associated with activation of fetal gene programs. Bone morphogenetic proteins (BMPs) regulate embryonic development through interaction with BMP receptors (BMPRs) on the cell surface. We investigated if the expression of BMP4 and its receptors BMPR1a and BMPR2 were activated in post-infarction remodeling and heart failure.Left ...
Xueping, Wu, Julia, Sagave, Arkady, Rutkovskiy, Fred, Haugen, Anton, Baysa, Ståle, Nygård, Gabor, Czibik, Christen Peder, Dahl, Lars, Gullestad, Jarle, Vaage, Guro, Valen   +10 more
openaire   +2 more sources