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Experimental Physiology, EarlyView.Abstract Chronic kidney disease–mineral and bone disorder (CKD‐MBD) is a major complication of chronic kidney disease (CKD), characterized by disruptions in mineral metabolism, abnormal bone turnover and vascular calcification, which collectively increase the risk of fractures and cardiovascular disease.
Alief Waitupu +4 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Propionate in the fetal circulation is thought to originate from fermentation of dietary fibre by the maternal gut microbiota. However, the mechanism of transplacental transport has remained unclear. Here, we measured propionate permeability using a placental barrier model generated by differentiating human placental trophoblast ...
Toshiaki Tsuchitani +8 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass +2 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos +7 more
wiley +1 more source
Growth Factors, 2003 Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the transforming growth factor beta (TGFbeta) superfamily. The roles of BMPs in embryonic development and cellular functions in postnatal and adult animals have been extensively studied in recent years. Signal transduction studies have revealed that Smad1, 5 and 8 are
Di, Chen, Ming, Zhao, Gregory R, Mundy
core +7 more sources
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Bone morphogenetic proteins in development
Current Opinion in Genetics and Development, 1996The bone morphogenetic proteins (BMPs) constitute a large family of cytokines related to members of the transforming growth factor-beta superfamily. Recent evidence, in particular from gene targeting experiments in the mouse, indicates that BMPs are required for mesoderm formation and for the development and patterning of many different organ systems ...
Brigid L M Hogan
exaly +3 more sources
Genes and Function, 1997
The concept that there is a substance in bone that can induce new-bone formation has been discussed for many years. However, the credit for the discovery of bone morphogenetic protein goes to Marshall R. Urist, who, in 1965, demonstrated the formation of bone by a process that he called autoinduction.
N, Ueno, M, Moos
openaire +3 more sources
The concept that there is a substance in bone that can induce new-bone formation has been discussed for many years. However, the credit for the discovery of bone morphogenetic protein goes to Marshall R. Urist, who, in 1965, demonstrated the formation of bone by a process that he called autoinduction.
N, Ueno, M, Moos
openaire +3 more sources
Biochemical and Biophysical Research Communications, 2007
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor-beta superfamily. It has been demonstrated that BMPs had been involved in the regulation of cell proliferation, survival, differentiation and apoptosis.
Yong-Tao, Xiao +2 more
openaire +2 more sources
Bone morphogenetic proteins (BMPs) are multi-functional growth factors belonging to the transforming growth factor-beta superfamily. It has been demonstrated that BMPs had been involved in the regulation of cell proliferation, survival, differentiation and apoptosis.
Yong-Tao, Xiao +2 more
openaire +2 more sources
Journal of neurosurgery. Spine, 2009
Although the authors used the same interbody spacers and even higher dose of rhBMP-2 (than the dose of rhBMP-2 was used in another report in which incidence of the resorptions after interbody fusions assisted with rhBMP-2 was 100%) there was no resorptions in their study. We asked for the authors' clarification of the strange phenomenon.
Smoljanović, Tomislav +2 more
openaire +4 more sources
Although the authors used the same interbody spacers and even higher dose of rhBMP-2 (than the dose of rhBMP-2 was used in another report in which incidence of the resorptions after interbody fusions assisted with rhBMP-2 was 100%) there was no resorptions in their study. We asked for the authors' clarification of the strange phenomenon.
Smoljanović, Tomislav +2 more
openaire +4 more sources