Generation of optimized preparations of bone morphogenetic proteins for bone regeneration [PDF]
The Ukrainian Biochemical Journal, 2016 Correction of inherited skeletal abnormalities, traumas affecting wide bone areas and non-healing fractures require efficient bone formation and regeneration.
Kh. V. Malysheva +2 more
doaj +1 more source
Acta Biomedica Scientifica, 2016 Modern therapeutic strategies for intervertebral disc repair mainly focus on targeting molecular pathways of extracellular matrix degeneration. Anabolic strategies for regeneration are aimed to increase production of major extracellular molecules ...
L. A. Bardonova +2 more
doaj +1 more source
Heterodimeric BMP-2/7 antagonizes the inhibition of all-trans retinoic acid and promotes the osteoblastogenesis. [PDF]
PLoS ONE, 2013 OBJECTIVES: Hypervitaminosis A and alcoholism can result in a low mineral density and compromised regenerative capacity of bone, thus delaying implant osteointegration.
Wenjuan Bi +5 more
doaj +1 more source
Development of an Aqueous Suspension of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) [PDF]
, 2005 Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) is a morphogen with the ability to induce the formation of cartilage and new bone. In the product currently on the market for some special orthopaedic indications, rhBMP-2 is implanted by invasive ...
Schwartz, Daniel
core +1 more source
Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect [PDF]
, 2013 The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Henrich, Dirk +5 more
core +1 more source
Journal of Tissue Engineering, 2012 The effects of bioactive glass S53P4 or beta-tricalcium phosphate; and bone morphogenetic proteins bone morphogenetic protein-2, bone morphogenetic protein-7, or bone morphogenetic protein-2 + 7 on osteogenic differentiation of human adipose stem cells ...
Martin Waselau +11 more
doaj +1 more source
Persistent expression of BMP-4 in embryonic chick adrenal cortical cells and its role in chromaffin cell development [PDF]
, 2008 Background: Adrenal chromaffin cells and sympathetic neurons both originate from the neural crest, yet signals that trigger chromaffin development remain elusive.
Huber, Katrin +39 more
core +1 more source
Current Methods for the Treatment of Alveolar Cleft
Archives of Plastic Surgery, 2017 Alveolar cleft is a tornado-shaped bone defect in the maxillary arch. The treatment goals for alveolar cleft are stabilization and provision of bone continuity to the maxillary arch, permitting support for tooth eruption, eliminating oronasal fistulas ...
Nak Heon Kang
doaj +1 more source
Endothelialized tissue engineered 3D-construct for bone repair [PDF]
, 2005 One of the main problems arising when implanting a graft into a large bone gap is its insufficient vascularization in the central region. This results in impaired bone healing and often leads to necrosis in the graft.
Meury, Thomas
core +1 more source
Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/b-tricalcium phosphate porous ceramics [PDF]
, 2009 The association of bone morphogenetic proteins (BMPs) with calcium phosphate bioceramics is known to confer them osteoinductive properties. The aim of this study was to evaluate the surface properties, especially regarding recombinant human BMP-2 (rhBMP-
Christèle Combes +19 more
core +1 more source