Results 31 to 40 of about 2,491,420 (247)
Journal of Experimental Orthopaedics, 2014 Background Trauma, osteomyelitis, bone tumour resections and congenital deformities are the main causes of bone deficiency in which autologous graft is the preferred treatment, but usually the bone supplies are limited.
Juan Carlos Jacinto‐Tinajero +6 more
doaj +1 more source
Structural and Metabolic Changes in Bone
Animals, 2022 As an essential component of the skeleton, bone tissue provides solid support for the body and protects vital organs. Bone tissue is a reservoir of calcium, phosphate, and other ions that can be released or stored in a controlled manner to provide ...
Agata Wawrzyniak, Krzysztof Balawender
doaj +1 more source
Genetics of ovulation rate in farm animals [PDF]
Veterinary World, 2013 Rate of ovulation (i.e. fecundity) is largely influenced by both genetic and environmental factors. The ovarian growth factorsincluding members of bone morphogenetic proteins (BMPs) play a central role in determining ovulation quota and litter size ...
Rohit Kumar +3 more
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, 2001 The hypothesis that growth hormone (GH) up-regulates the expression of enzymes, matrix proteins, and differentiation markers involved in mineralization of tooth and bone matrices was tested by the treatment of Lewis dwarf rats with GH over 5 days.
Bartold, P. Mark +14 more
core +1 more source
Functional analysis of alleged NOGGIN mutation G92E disproves its pathogenic relevance.
PLoS ONE, 2012 We identified an amino acid change (p.G92E) in the Bone Morphogenetic Protein antagonist NOGGIN in a 22-month-old boy who presented with a unilateral brachydactyly type B phenotype. Brachydactyly type B is a skeletal malformation that has been associated
Julia Zimmer +6 more
doaj +1 more source
Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix
FEBS Letters, EarlyView.The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual +3 more
wiley +1 more source
IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo
FEBS Open Bio, EarlyView.To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Efficient recovery from traumatic or degenerative diseases is a great challenge, even after all the advancements in bone and cartilage regeneration. Machine learning (ML) algorithms have presented opportunities to enhance these aspects by accurately analyzing imaging data.
Maryam Kamaei +9 more
wiley +1 more source
Cross-talk between bone morphogenetic proteins and inflammatory pathways [PDF]
, 2015 Contains fulltext : 152090.pdf (Publisher’s version ) (Open Access)Pro-inflammatory cytokines and bone morphogenetic proteins are generally studied separately and considered to be elements of different worlds, immunology and ...
Esmeralda N. Blaney Davidson +3 more
core +2 more sources
Advanced Healthcare Materials, EarlyView.We developed a patient‐derived, functional microfluidic model of the diffuse midline glioma (DMG) blood–brain–tumor barrier (BBTB) comprised of endothelial cells, astrocytes, pericytes, and tumor cells. The system forms perfusable microvasculature, reveals the BBTB retains vascular integrity, identifies DMG‐specific transcriptomic changes distinct from
Kimberly R. Bennett +7 more
wiley +1 more source