Results 11 to 20 of about 196,593 (268)

Allergy-induced systemic inflammation impairs tendon quality

EBioMedicine, 2022
Summary: Background: Treatment of degenerating tendons still presents a major challenge, since the aetiology of tendinopathies remains poorly understood.
Christine Lehner, Gabriel Spitzer, Patrick Langthaler, Dominika Jakubecova, Barbara Klein, Nadja Weissenbacher, Andrea Wagner, Renate Gehwolf, Eugen Trinka, Bernhard Iglseder, Bernhard Paulweber, Ludwig Aigner, Sebastien Couillard-Després, Richard Weiss, Herbert Tempfer, Andreas Traweger   +15 more
doaj   +1 more source

Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1

Disease Models & Mechanisms, 2019
Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined.
Christine Lehner, Gabriel Spitzer, Renate Gehwolf, Andrea Wagner, Nadja Weissenbacher, Christian Deininger, Katja Emmanuel, Florian Wichlas, Herbert Tempfer, Andreas Traweger   +9 more
doaj   +1 more source

Global Responses of Il-1β-Primed 3D Tendon Constructs to Treatment with Pulsed Electromagnetic Fields

Cells, 2019
Tendinopathy is accompanied by a cascade of inflammatory events promoting tendon degeneration. Among various cytokines, interleukin-1β plays a central role in driving catabolic processes, ultimately resulting in the activation of matrix ...
Renate Gehwolf, Bettina Schwemberger, Malik Jessen, Stefanie Korntner, Andrea Wagner, Christine Lehner, Nadja Weissenbacher, Herbert Tempfer, Andreas Traweger   +8 more
doaj   +1 more source

Unveiling the Osteogenic Potential of Tetracyclines: A Comparative Study in Human Mesenchymal Stem Cells

Cells, 2023
Tetracyclines (TCs) are a class of broad-spectrum antibiotics with diverse pharmacotherapeutic properties due to their various functional groups being attached to a common core structure.
Victor Martin, Ana Francisca Bettencourt, Catarina Santos, Maria Helena Fernandes, Pedro Sousa Gomes   +4 more
doaj   +1 more source

A high-glucose diet affects Achilles tendon healing in rats

Scientific Reports, 2017
Chronic and acute tendinopathies are difficult to treat and tendon healing is generally a very slow and incomplete process and our general understanding of tendon biology and regeneration lags behind that of muscle or bone.
Stefanie Korntner, Nadja Kunkel, Christine Lehner, Renate Gehwolf, Andrea Wagner, Peter Augat, Daniel Stephan, Verena Heu, Hans-Christian Bauer, Andreas Traweger, Herbert Tempfer   +10 more
doaj   +1 more source

Diallyl Disulfide Induces Apoptosis and Autophagy in Human Osteosarcoma MG-63 Cells through the PI3K/Akt/mTOR Pathway

Molecules, 2019
Diallyl disulfide (DADs), a natural organic compound, is extracted from garlic and scallion and has anti-tumor effects against various tumors. This study investigated the anti-tumor activity of DADs in human osteosarcoma cells and the mechanisms.
Ziqi Yue, Xin Guan, Rui Chao, Cancan Huang, Dongfang Li, Panpan Yang, Shanshan Liu, Tomoka Hasegawa, Jie Guo, Minqi Li   +9 more
doaj   +1 more source

Custom 3D-Printed Triflange Implants for Treatment of Severe Acetabular Defects, with and without Pelvic Discontinuity

JBJS Open Access, 2021
Background:. Treatment of massive acetabular defects, both with and without pelvic discontinuity, is challenging. The implants utilized in the surgical procedure need to be stable and integrate with poor host bone stock. In the present study, we describe
Vitali Goriainov, BM, FRCS(Orth), Msc, PhD, Leonard J. King, MB, ChB, FRCP, FRCR, Richard O.C. Oreffo, DPhil, DSc(Oxon), FHEA, CBiol, FRSB, FIOR, Douglas G. Dunlop, MBBCh, FRCS, FRCSEd(TR&Orth), MD   +3 more
doaj   +1 more source

Peroxiredoxin 1 regulates crosstalk between pyroptosis and autophagy in oral squamous cell carcinoma leading to a potential pro-survival

Cell Death Discovery, 2023
Peroxiredoxin 1 (Prdx1), a vital antioxidant enzyme, has been proven to play an important role in the occurrence and development of cancers, but its effects on oral squamous cell carcinoma (OSCC) remain unclear. Here, we performed bioinformatics analysis
Meilin Ye, Ting Liu, Shanshan Liu, Rong Tang, Hongrui Liu, Fan Zhang, Shenglei Luo, Minqi Li   +7 more
doaj   +1 more source

The Synergistic Effect of Zuogui Pill and Eldecalcitol on Improving Bone Mass and Osteogenesis in Type 2 Diabetic Osteoporosis

Medicina, 2023
Background and Objectives: The incidence of diabetic osteoporosis, an important complication of diabetes mellitus, is increasing gradually. This study investigated the combined effect of the Zuogui pill (ZGP) and eldecalcitol (ED-71), a novel vitamin D ...
Tuo Shi, Ting Liu, Yuying Kou, Xing Rong, Lingxiao Meng, Yajun Cui, Ruihan Gao, Sumin Hu, Minqi Li   +8 more
doaj   +1 more source

The Embryonic Chick Femur Organotypic Model as a Tool to Analyze the Angiotensin II Axis on Bone Tissue

Pharmaceuticals, 2021
Activation of renin–angiotensin system (RAS) plays a role in bone deterioration associated with bone metabolic disorders, via increased Angiotensin II (AngII) targeting Angiotensin II type 1 receptor/Angiotensin II type 2 receptor (AT1R/AT2R).
Thais Francini Garbieri, Victor Martin, Carlos Ferreira Santos, Pedro de Sousa Gomes, Maria Helena Fernandes   +4 more
doaj   +1 more source