Results 11 to 20 of about 174,184 (273)
Strontium-releasing mesoporous bioactive glasses with anti-adhesive zwitterionic surface as advanced biomaterials for bone tissue regeneration [PDF]
Journal of Colloid and Interface Science 563, 92-103 (2020), 2021 Hypothesis The treatment of bone fractures still represents a challenging clinical issue when complications due to impaired bone remodelling (i.e. osteoporosis) or infections occur. These clinical needs still require a radical improvement of the existing therapeutic approach through the design of advanced biomaterials combining the ability to promote ...
arxiv +1 more source
Stem Cell Research & Therapy, 2022 Background The incidence of diabetic osteoporosis is increasing. This article evaluates the effect of combination treatment with the hypoglycemic drug exendin-4 (Ex-4) and the vitamin D analog eldecalcitol (ED-71) on improving diabetic osteoporosis and ...
Yupu Lu +6 more
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Bioengineering, 2022 This work intended to elucidate, in an in vitro approach, the cellular and molecular mechanisms occurring during the bone healing process, upon implantation of a tailored degradable multifunctional Mg-based alloy.
Victor Martin +5 more
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Di-san junyi daxue xuebao, 2020 Objective To investigate the effect and underlying mechanism of activating Notch signaling in osteocytes on osteogenic differentiation of bone marrow stromal cells (BMSCs). Methods The osteocytes derived from RosaNotch mice were infected with recombinant
XIE Yingchun, TU Xiaolin
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Frontiers in Pharmacology, 2023 Background: Aging and oxidative stress are considered to be the proximal culprits of postmenopausal osteoporosis. Eldecalcitol (ED-71), a new active vitamin D derivative, has shown a good therapeutic effect on different types of osteoporosis, but the ...
Yuying Kou +15 more
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3D scaffold with effective multidrug sequential release against bacteria biofilm [PDF]
Acta Biomaterialia. 49, 113-126 (2017), 2021 Bone infection is a feared complication following surgery or trauma that remains as an extremely difficult disease to deal with. So far, the outcome of therapy could be improved with the design of 3D implants, which combine the merits of osseous regeneration and local multidrug therapy so as to avoid bacterial growth, drug resistance and the feared ...
arxiv +1 more source
The blood-tendon barrier: identification and characterisation of a novel tissue barrier in tendon blood vessels [PDF]
European Cells & Materials, 2016 Tissue barriers function as “gate keepers” between different compartments (usually blood and tissue) and are formed by specialised membrane-associated proteins, localising to the apicolateral plasma membrane domain of epithelial and endothelial cells. By
C Lehner +7 more
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Hierarchical porosity ihnerited by natural sources affects the mechanical and biological behaviour of bone scaffolds [PDF]
Journal of the European Ceramic Society 40 (2020) 1717-1727, 2021 A 3-D porous apatite scaffold (B-HA), recently obtained through biomorphic transformation of a natural wood, is investigated on its multi-scale porous structure determining superior mechanical properties and biological behaviour. B-HA shows hierarchical pore architecture with wide aligned channels interconnected with smaller tubules, thus ...
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Tenophages: a novel macrophage-like tendon cell population expressing CX3CL1 and CX3CR1
Disease Models & Mechanisms, 2019 Tendon disorders frequently occur and recent evidence has clearly implicated the presence of immune cells and inflammatory events during early tendinopathy. However, the origin and properties of these cells remain poorly defined.
Christine Lehner +9 more
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Cells, 2019 Tendinopathy is accompanied by a cascade of inflammatory events promoting tendon degeneration. Among various cytokines, interleukin-1β plays a central role in driving catabolic processes, ultimately resulting in the activation of matrix ...
Renate Gehwolf +8 more
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