Osteoarthritis (OA) and osteoporosis (OP) are two skeletal disorders associated with joint structures. Occasionally, OA and OP occur in the same patient. However, the effect of OP changes on OA progression in patients with osteoporotic OA (OP‐OA) has not
L. Chu+7 more
semanticscholar +1 more source
The influence of bone surface availability in bone remodelling - A mathematical model including coupled geometrical and biomechanical regulations of bone cells [PDF]
Bone is a biomaterial undergoing continuous renewal. The renewal process is known as bone remodelling and is operated by bone-resorbing cells (osteoclasts) and bone-forming cells (osteoblasts). Both biochemical and biomechanical regulatory mechanisms have been identified in the interaction between osteoclasts and osteoblasts.
arxiv +1 more source
D-methionine eradicates Porphyromonas gingivalis biofilms by suppressing the cyclic di-GMP level
Objective To investigate the mechanisms by which D-methionine (D-Met) eradicates Porphyromonas gingivalis biofilms by suppressing cyclic dimeric GMP (c-di-GMP) levels.
XIE Lili+5 more
doaj +1 more source
Concurrent consideration of cortical and cancellous bone within continuum bone remodelling [PDF]
Continuum bone remodelling is an important tool for predicting the effects of mechanical stimuli on bone density evolution. While the modelling of only cancellous bone is considered in many studies based on continuum bone remodelling, this work presents an approach of modelling also cortical bone and the interaction of both bone types.
arxiv +1 more source
Research progress on the role and mechanism of miR-671 in bone metabolism and bone-related diseases
Bone metabolism consists of bone formation and resorption and maintains a dynamic balance in vivo. When bone homeostasis is broken, it can manifest as osteoarthritis (OA), rheumatoid arthritis (RA), osteosarcoma (OS), etc.
Shaotai Wang+8 more
doaj +1 more source
Bone remodelling at a glance [PDF]
The bone remodelling cycle (see Poster panel “The bone remodelling cycle”) maintains the integrity of the skeleton through the balanced activities of its constituent cell types. These are the bone-forming osteoblast, a cell that produces the organic bone matrix and aids its mineralisation ([
Lynne J. Hocking+4 more
openaire +3 more sources
Investigation of the cellular response to bone fractures: evidence for flexoelectricity [PDF]
The recent discovery of bone flexoelectricity (electrical polarization induced by strain gradient) suggests that flexoelectricity could have physiological effects in bones, and specifically near bone fractures, where flexoelectricity is theoretically highest. Here, we report a cytological study of the interaction between crack stress and bone cells. We
arxiv +1 more source
Endocortical bone loss in osteoporosis: The role of bone surface availability [PDF]
Age-related bone loss and postmenopausal osteoporosis are disorders of bone remodelling, in which less bone is reformed than resorbed. Yet, this dysregulation of bone remodelling does not occur equally in all bone regions. Loss of bone is more pronounced near and at the endocortex, leading to cortical wall thinning and medullary cavity expansion, a ...
arxiv +1 more source
Regulation of epigenetic modifications in the head and neck tumour microenvironment
Head and neck tumours are common malignancies that are associated with high mortality. The low rate of early diagnosis and the high rates of local recurrence and distant metastasis are the main reasons for treatment failure.
Huimin Liu+16 more
doaj +1 more source
Oxidative stress in bone remodeling: role of antioxidants.
ROS are highly reactive molecules which consist of a number of diverse chemical species, including radical and non-radical oxygen species. Oxidative stress occurs as a result of an overproduction of ROS not balanced by an adequate level of antioxidants ...
Vladana Domazetovic+4 more
semanticscholar +1 more source