Results 71 to 80 of about 2,011,561 (382)

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Engineered stem cell exosomes for oral and maxillofacial wound healing

Frontiers in Bioengineering and Biotechnology, 2022
Wound healing of the oral and maxillofacial area affects the quality of life and mental health of the patient; therefore, effective therapies are required to promote wound healing. However, traditional treatment methods have limited efficacy.
Ming Hao, Ming Hao, MengNa Duan, Zhijing Yang, Zhijing Yang, Hengzong Zhou, Shuangji Li, Shuangji Li, Jingcheng Xiang, Jingcheng Xiang, Han Wu, Han Wu, Huimin Liu, Huimin Liu, Lu Chang, Lu Chang, Dongxu Wang, Weiwei Liu, Weiwei Liu   +18 more
doaj   +1 more source

Mechanisms of gut microbiota-mediated bone remodeling

Gut microbes, 2018
The mechanisms underlying the systemic effects mediated by gut microbiota are under active investigation. In addition to local, direct effects of gut microbiota on the host, metabolic products from microbiota may act peripherally, reaching distal organs ...
Jing Yan, A. Takakura, K. Zandi‐Nejad, J. Charles   +3 more
semanticscholar   +1 more source

Towards a New Spatial Representation of Bone Remodeling [PDF]

, 2011
Irregular bone remodeling is associated with a number of bone diseases such as osteoporosis and multiple myeloma. Computational and mathematical modeling can aid in therapy and treatment as well as understanding fundamental biology. Different approaches to modeling give insight into different aspects of a phenomena so it is useful to have an arsenal ...
arxiv   +1 more source

The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis

Molecular Oncology, EarlyView.
This study explores how sepsis affects GC progression by creating an immunosuppressive environment. Our findings reveal that sepsis promotes immune dysregulation, enhancing tumor growth and metastasis. Targeting the PD‐1/PD‐L1 pathway with monoclonal antibodies shows potential for restoring immune function and improving outcomes in cancer patients ...
Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li   +10 more
wiley   +1 more source

A multiscale mechanobiological model of bone remodelling predicts site-specific bone loss in the femur during osteoporosis and mechanical disuse [PDF]

Biomech. Model. Mechanobiol. (2016) 15:43-67, 2015
We propose a multiscale mechanobiological model of bone remodelling to investigate the site-specific evolution of bone volume fraction across the midshaft of a femur. The model includes hormonal regulation and biochemical coupling of bone cell populations, the influence of the microstructure on bone turnover rate, and mechanical adaptation of the ...
arxiv   +1 more source

Robust acute myeloid leukemia engraftment in humanized scaffolds using injectable biomaterials and intravenous xenotransplantation

Molecular Oncology, EarlyView.
Patient‐derived xenografts (PDXs) can be improved by implantation of a humanized niche. We tested different biomaterials and approaches, and demonstrate that the combination of an injectable biomaterial for scaffold creation plus an intravenous route for acute myeloid leukemia (AML) xenotransplantation provide the most convenient and robust approach to
Daniel Busa, Zdenka Herudkova, Jan Hyl, Jakub Vlazny, Filip Sokol, Kvetoslava Matulova, Adam Folta, Jakub Hynst, Lucy Vojtova, Leos Kren, Martin Repko, Zdenek Racil, Jiri Mayer, Martin Culen   +13 more
wiley   +1 more source

Role of epigenetic modification in interferon treatment of hepatitis B virus infection

Frontiers in Immunology, 2022
Human hepatitis B virus (HBV) is a small, enveloped DNA virus that causes acute and chronic hepatitis. Chronic hepatitis B (CHB) is associated with hepatocellular carcinoma pathogenesis.
Zhijing Yang, Zhijing Yang, Baozhen Sun, Jingcheng Xiang, Jingcheng Xiang, Han Wu, Han Wu, Shaoning Kan, Shaoning Kan, Ming Hao, Ming Hao, Lu Chang, Lu Chang, Huimin Liu, Huimin Liu, Dongxu Wang, Weiwei Liu, Weiwei Liu   +17 more
doaj   +1 more source

Bone remodeling-inspired dual delivery electrospun nanofibers for promoting bone regeneration.

Nanoscale, 2018
Developing a highly bioactive bone tissue engineering scaffold that can modulate the bone remodeling process for promoting bone regeneration is a great challenge.
Yi Wang, W. Cui, Xin Zhao, S. Wen, Yulong Sun, Jianmin Han, Hongyu Zhang   +6 more
semanticscholar   +1 more source

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source