Results 1 to 10 of about 300,859 (269)

FTY720 Attenuates LPS-Induced Inflammatory Bone Loss by Inhibiting Osteoclastogenesis via the NF-κB and HDAC4/ATF Pathways

Journal of Immunology Research, 2023
Osteoclast (OC) abnormalities lead to many osteolytic diseases, such as osteoporosis, inflammatory bone erosion, and tumor-induced osteolysis. Exploring effective strategies to remediate OCs dysregulation is essential.
Chongwei Chen, Sujing Zong, Zhenyu Wang, Ruijia Yang, Yanjing Guo, Yunfei Wang, Xinping Chen, Yue Li, Shaowei Wang   +8 more
doaj   +1 more source

Upregulated ribosome pathway plays a key role in HDAC4, improving the survival rate and biofunction of chondrocytes

Bone & Joint Research, 2023
Aims: To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis. Methods: Empty adenovirus (EP) and a HDAC4 overexpression adenovirus were transfected into cultured human chondrocytes.
Li Guo, Hua Guo, Yuanyu Zhang, Zhi Chen, Jian Sun, Gaige Wu, Yunfei Wang, Yang Zhang, Xiaochun Wei, Pengcui Li   +9 more
doaj   +1 more source

Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Bone Research, 2022
The intervertebral disc (IVD) is the largest avascular tissue. Hypoxia-inducible factors (HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease (DDD) is one of the leading causes
Zuqiang Wang, Hangang Chen, Qiaoyan Tan, Junlan Huang, Siru Zhou, Fengtao Luo, Dali Zhang, Jing Yang, Can Li, Bo Chen, Xianding Sun, Liang Kuang, Wanling Jiang, Zhenhong Ni, Quan Wang, Shuai Chen, Xiaolan Du, Di Chen, Chuxia Deng, Liangjun Yin, Lin Chen, Yangli Xie   +21 more
doaj   +1 more source

Exploring the displacement characteristics of Garden III femoral neck fractures and the reliability, validity, and value of the anteroposterior Garden Index in assessing displacement severity

Journal of Orthopaedic Surgery and Research, 2023
Background Femoral neck fractures represent a significant public health concern, particularly in the elderly population. A thorough understanding and assessment of these fractures are deemed essential for optimal treatment and management.
Bo Cong, Ziyin Han, Haiguang Zhang
doaj   +1 more source

Prevention of sclerosis around cannulated screw after treatment of femoral neck fractures with bioceramic nails: a finite element analysis

BMC Musculoskeletal Disorders, 2023
Purpose Conventional cannulated screws (CS) are the main treatment method for femoral neck fractures (FNF). However, the rate of femoral head necrosis remains high after FNF treatment.
Yang Liu, Yugang Xing, Huifeng Shao, Xiaogang Wu, Yongsheng Ma, Wenming Yang, Qitai Lin, Pengcui Li, Yong He, Wangping Duan, Xiaochun Wei   +10 more
doaj   +1 more source

Gait Analysis of Bilateral Knee Osteoarthritis and Its Correlation with Western Ontario and McMaster University Osteoarthritis Index Assessment

Medicina, 2022
Background and objectives: Objective, accurate, and intuitive evaluation of knee joint function in patients with knee osteoarthritis (KOA) is important.
Haoqian Li, Shuai Hu, Ruipeng Zhao, Yixuan Zhang, Lingan Huang, Junjun Shi, Pengcui Li, Xiaochun Wei   +7 more
doaj   +1 more source

HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

BMC Musculoskeletal Disorders, 2022
Background The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA).
Xiaodong Gu, Fei Li, Yangyang Gao, Xianda Che, Pengcui Li   +4 more
doaj   +1 more source

α2-macroglobulin-rich serum as a master inhibitor of inflammatory factors attenuates cartilage degeneration in a mini pig model of osteoarthritis induced by “idealized” anterior cruciate ligament reconstruction

Frontiers in Pharmacology, 2022
Post-traumatic osteoarthritis is a special type of osteoarthritis and a common disease, with few effective treatments available. α2-Macroglobulin (α2M) is important to chondral protection in post-traumatic osteoarthritis.
Ruipeng Zhao, Xiaochun Wei, Chengming Zhang, Hongru Wu, Chuan Xiang, Haoqian Li, Wangping Duan, Zhiqing Duan, Chunjiang Li, Yu Zhao, Lingan Huang, Lingan Huang   +11 more
doaj   +1 more source

Predicting Angiogenesis by Endothelial Progenitor Cells Relying on In-Vitro Function Assays and VEGFR-2 Expression Levels

Biomolecules, 2019
Clinical trials have demonstrated the safety and efficacy of autologous endothelial progenitor cell (EPC) therapy in various diseases. Since EPCs’ functions are influenced by genetic, systemic and environmental factors, the therapeutic potential of
Nadin Sabbah, Tal Tamari, Rina Elimelech, Ofri Doppelt, Utai Rudich, Hadar Zigdon-Giladi   +5 more
doaj   +1 more source

Effect of Moderate Exercise on the Superficial Zone of Articular Cartilage in Age-Related Osteoarthritis

Diagnostics, 2023
This study aimed to evaluate the effect of exercise on the superficial zone of the osteoarticular cartilage during osteoarthritis progression. Three-month-old, nine-month-old, and eighteen-month-old Sprague Dawley rats were randomly divided into two ...
Yukun Yin, Yuanyu Zhang, Li Guo, Pengcui Li, Dongming Wang, Lingan Huang, Xiaoqin Zhao, Gaige Wu, Lu Li, Xiaochun Wei   +9 more
doaj   +1 more source