Results 31 to 40 of about 326,067 (120)

rhBMP in lumber fusion for lumbar spondylolisthesis: A systematic review and meta-analysis

Chinese Journal of Traumatology, 2019
Purpose: To compare the efficacy and safety of recombinant human bone morphogenetic protein (rhBMP) and iliac crest autograft in the fusion treatment of lumbar spondylolisthesis.
Peng-Fei Han, Tao-Yu Chen, Zhi-Liang Zhang, Xiao-Dong Li, Peng-Cui Li, Lei Wei, Zhi Lü, Xiao-Chun Wei   +7 more
doaj   +1 more source

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio
Several studies have previously shown that histone deacetylase 4 (HDAC4) can regulate endoplasmic reticulum stress‐induced apoptosis through the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
doaj   +1 more source

IHH–GLI-1–HIF-2α signalling influences hypertrophic chondrocytes to exacerbate osteoarthritis progression

Journal of Orthopaedic Translation
Background: Chondrocyte hypertrophy is a potential target for osteoarthritis (OA) treatment, with Indian hedgehog (IHH), glioma-associated oncogene homolog (GLI), and hypoxia-inducible factor-2α (HIF-2α) being closely associated with chondrocyte ...
Chengming Zhang, Ruipeng Zhao, Zhengquan Dong, Yang Liu, Mengrou Liu, Haoqian Li, Yukun Yin, Xianda Che, Gaige Wu, li Guo, Pengcui Li, Xiaochun Wei, Ziquan Yang   +12 more
doaj   +1 more source

mPPTMP195 nanoparticles enhance fracture recovery through HDAC4 nuclear translocation inhibition

Journal of Nanobiotechnology
Delayed repair of fractures seriously impacts patients’ health and significantly increases financial burdens. Consequently, there is a growing clinical demand for effective fracture treatment.
Xinping Chen, Chengwei Li, Jiyu Zhao, Yunxiang Liu, Zhizhong Zhao, Zhenyu Wang, Yue Li, Yunfei Wang, Lixia Guo, Lu Li, Chongwei Chen, Bing Bai, Shaowei Wang   +12 more
doaj   +1 more source

Anti-arthritic activities of cross-linked hyaluronic acid-dexamethasone hydrogel in a rat model of gouty arthritis

Frontiers in Pharmacology
BackgroundGouty arthritis (GA) is a type of inflammatory joint disease in which the deposition of monosodium urate (MSU) crystals inside the joints leads to severe inflammatory reactions, such as synovitis. Cross-linked hyaluronic acid hydrogel (cHA gel)
Jingya Zhao, Peichu Tian, Peichu Tian, Binsheng Li, Yuqi Yang, Mengyu Fu, Tao Zhang, Zhiwei Zhang, Li Wu   +8 more
doaj   +1 more source

The silencing of NREP aggravates OA cartilage damage through the TGF-β1/Smad2/3 pathway in chondrocytes

Journal of Orthopaedic Translation
Background: Osteoarthritis (OA) is a common chronic degenerative joint disease. Due to the limited understanding of its complex pathological mechanism, there is currently no effective treatment that can alleviate or even reverse cartilage damage ...
Yang Liu, Mengrou Liu, Chengming Zhang, Xiaoke Li, Siyu Zheng, Le Wen, Peidong Liu, Pengcui Li, Ziquan Yang   +8 more
doaj   +1 more source

Development and validation of a nomogram prediction model for perioperative deep vein thrombosis risk in arthroplasty: a retrospective study

Frontiers in Medicine
BackgroundPerioperative monitoring thrombosis has become more crucial due to the rising demand for arthroplasty and shorter hospital stays. We aimed to comprehensively explore immune-inflammatory and hypercoagulable states during perioperative periods ...
Wenming Yang, Wenming Yang, Qitai Lin, Qitai Lin, Zehao Li, Zehao Li, Chuanjie Shan, Chuanjie Shan, Xiaoyu Cheng, Yugang Xing, Yugang Xing, Yongsheng Ma, Yongsheng Ma, Yang Liu, Yang Liu, Meiming Li, Meiming Li, Ruifeng Liang, Wangping Duan, Wangping Duan, Wangping Duan, Pengcui Li, Pengcui Li, Xiaochun Wei, Xiaochun Wei   +24 more
doaj   +1 more source

Physically crosslinked poly(vinyl alcohol)-based hydrogels for cartilage tissue engineering

Materials & Design
Due to the limited self-healing ability of cartilage, cartilage defect repair remains a challenge in clinical treatment. Therefore, there is a need to provide patients with a promising cartilage defect repair strategy.
Changxin Xiang, Zijian Guo, Qing Zhang, Zehua Wang, Xiaona Li, Weiyi Chen, Xiaochun Wei, Pengcui Li, Chuan Xiang   +8 more
doaj   +1 more source

Acute compartment syndrome in tibial fractures: a meta-analysis

BMC Musculoskeletal Disorders
Purpose Acute compartment syndrome (ACS) is a severe complication associated with tibial fractures, which can result in irreversible muscle and nerve damage if not promptly identified and treated. Method This study systematically searched PubMed, EMBASE,
Bo Cong, Haiguang Zhang
doaj   +1 more source

Biportal endoscopic spinal surgery for thoracic ossification of the ligamentum flavum: a study of different classification types and surgical outcomes

Frontiers in Neurology
BackgroundThis study aimed to assess potential differences in the clinical effectiveness of biportal endoscopic spinal surgery (BESS) for treating various axial classifications of ossification of the ligamentum flavum (OLF).MethodsWe retrospectively ...
Honggang Wang, Honggang Wang, Dongqing He, Dongqing He, Ruxing Liu, Ruxing Liu, Jie Yuan, Jie Yuan, Yongfeng Wang, Yongfeng Wang   +9 more
doaj   +1 more source