Results 31 to 40 of about 310,996 (266)

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway

Molecular Medicine
Background Soy isoflavones (SI) is a natural bioactive substance exhibiting beneficial effects on human health. This study aims to elucidate the therapeutic potential of SI in the treatment of osteosarcoma (OS) and to investigate the underlying ...
Ziang Zheng, Xinghan Zhao, Bo Yuan, Shan Jiang, Rushan Yan, Xiaowei Dong, Qijun Yao, Haidong Liang   +7 more
doaj   +1 more source

The Paracrine Role of Endothelial Cells in Bone Formation via CXCR4/SDF-1 Pathway

Cells, 2020
Vascularization is a prerequisite for bone formation. Endothelial progenitor cells (EPCs) stimulate bone formation by creating a vascular network. Moreover, EPCs secrete various bioactive molecules that may regulate bone formation.
Tal Tamari, Rawan Kawar-Jaraisy, Ofri Doppelt, Ben Giladi, Nadin Sabbah, Hadar Zigdon-Giladi   +5 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Ultra depth of field microscopy: a novel method for observing and characterizing of articular cartilage surface

Journal of Translational Medicine
Background The surface microstructures of cartilage are closely related to its functions. Accurate observation of cartilage surface is key to researching cartilage-related diseases.
Guohao Zhang, Ningning Ma, Jihao Wen, Tao Zhang, Ruxing Liu, Mengyu Fu, Li Guo, Xiaochun Wei   +7 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

GOLGB1 deficiency accelerates intervertebral disc degeneration by activating the MAPK pathway

Scientific Reports
Intervertebral disc degeneration (IDD) is a multifactorially regulated age-related condition. Golgin B1 (GOLGB1) is a large Golgi-related transmembrane protein encoded by golgb1 gene.
Jingyuan Tian, Zhiquan Wang, Ruxing Liu, Xiaoting Qiu, Dongqin He, Nan Shan, Qichao Li, Guanghui He, Bin Zhao, Jie Yuan, Yongfeng Wang   +10 more
doaj   +1 more source

A new device and method for detecting the permeability of articular cartilage

Frontiers in Bioengineering and Biotechnology
ObjectiveArticular cartilage relies on synovial fluid for substance exchange, with permeability being a key parameter linked to its physiological functions and degenerative disease mechanisms.
Fuyang Cao, Fuyang Cao, Haibin Deng, Haibin Deng, Guohao Zhang, Guohao Zhang, Ningning Ma, Ningning Ma, Binghang Zhang, Binghang Zhang, Xianda Che, Xianda Che, Gaige Wu, Gaige Wu, Pengcui Li, Pengcui Li, Li Guo, Li Guo, Xiaochun Wei, Xiaochun Wei   +19 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source