Results 51 to 60 of about 310,996 (266)

Impairment of chondrocyte proliferation after exposure of young murine cartilage to an aged systemic environment in a heterochronic parabiosis model

Swiss Medical Weekly, 2018
AIM The aim of this study was to investigate whether an aged systemic environment could impair young cartilage tissue in mice. METHODS Mice differing in age were randomly divided into three groups ...
Lu Li, Xiaochun Wei, Xiang Geng, Zhiqing Duan, Xiaohu Wang, Pengcui Li, Chunfang Wang, Lei Wei   +7 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

rhBMP in lumber fusion for lumbar spondylolisthesis: A systematic review and meta-analysis

Chinese Journal of Traumatology, 2019
Purpose: To compare the efficacy and safety of recombinant human bone morphogenetic protein (rhBMP) and iliac crest autograft in the fusion treatment of lumbar spondylolisthesis.
Peng-Fei Han, Tao-Yu Chen, Zhi-Liang Zhang, Xiao-Dong Li, Peng-Cui Li, Lei Wei, Zhi Lü, Xiao-Chun Wei   +7 more
doaj   +1 more source

A FURTHER STUDY OF BONE REPAIR [PDF]

Southern Medical Journal, 1916
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Cohn, Isidore, Mann, Gustav
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

LMK-235 suppresses osteoclastogenesis and promotes osteoblastogenesis by inhibiting HDAC4

Scientific Reports
Osteoblasts and osteoclasts play an important role in maintaining the structural integrity of bone tissue, in which osteoclasts degrade bone structure and osteoblasts restore bone tissue.
Chongwei Chen, Yue Li, Teng Feng, Xinping Chen, Chengwei Li, Lu Li, Mengbo Zhu, Yaqiong Chang, Shaowei Wang   +8 more
doaj   +1 more source

IHH–GLI-1–HIF-2α signalling influences hypertrophic chondrocytes to exacerbate osteoarthritis progression

Journal of Orthopaedic Translation
Background: Chondrocyte hypertrophy is a potential target for osteoarthritis (OA) treatment, with Indian hedgehog (IHH), glioma-associated oncogene homolog (GLI), and hypoxia-inducible factor-2α (HIF-2α) being closely associated with chondrocyte ...
Chengming Zhang, Ruipeng Zhao, Zhengquan Dong, Yang Liu, Mengrou Liu, Haoqian Li, Yukun Yin, Xianda Che, Gaige Wu, li Guo, Pengcui Li, Xiaochun Wei, Ziquan Yang   +12 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio
Several studies have previously shown that histone deacetylase 4 (HDAC4) can regulate endoplasmic reticulum stress‐induced apoptosis through the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
doaj   +1 more source

Repair Mechanisms for Microdamage in Bone [PDF]

Journal of Bone and Mineral Research, 2014
When Harold Frost first identifiedmicrodamage generated in vivo in bone, hewas referring only to linearmicrocracks that were discrete and whose edges could be identified microscopically. Whether these were real or artifactual was a source of debate for many years until, in the early 1990s, more than a few laboratories had observed them using Frost’s en
openaire   +2 more sources