Results 61 to 70 of about 311,178 (265)

mPPTMP195 nanoparticles enhance fracture recovery through HDAC4 nuclear translocation inhibition

Journal of Nanobiotechnology
Delayed repair of fractures seriously impacts patients’ health and significantly increases financial burdens. Consequently, there is a growing clinical demand for effective fracture treatment.
Xinping Chen, Chengwei Li, Jiyu Zhao, Yunxiang Liu, Zhizhong Zhao, Zhenyu Wang, Yue Li, Yunfei Wang, Lixia Guo, Lu Li, Chongwei Chen, Bing Bai, Shaowei Wang   +12 more
doaj   +1 more source

Mechanisms of bone repair and regeneration

Trends in Molecular Medicine, 2009
Bone problems can have a highly deleterious impact on life and society, therefore understanding the mechanisms of bone repair is important. In vivo studies show that bone repair processes in adults resemble normal development of the skeleton during embryogenesis, which can thus be used as a model.
Deschaseaux, F., Sensebe, L., Heymann, D.   +2 more
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Anti-arthritic activities of cross-linked hyaluronic acid-dexamethasone hydrogel in a rat model of gouty arthritis

Frontiers in Pharmacology
BackgroundGouty arthritis (GA) is a type of inflammatory joint disease in which the deposition of monosodium urate (MSU) crystals inside the joints leads to severe inflammatory reactions, such as synovitis. Cross-linked hyaluronic acid hydrogel (cHA gel)
Jingya Zhao, Peichu Tian, Peichu Tian, Binsheng Li, Yuqi Yang, Mengyu Fu, Tao Zhang, Zhiwei Zhang, Li Wu   +8 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

The silencing of NREP aggravates OA cartilage damage through the TGF-β1/Smad2/3 pathway in chondrocytes

Journal of Orthopaedic Translation
Background: Osteoarthritis (OA) is a common chronic degenerative joint disease. Due to the limited understanding of its complex pathological mechanism, there is currently no effective treatment that can alleviate or even reverse cartilage damage ...
Yang Liu, Mengrou Liu, Chengming Zhang, Xiaoke Li, Siyu Zheng, Le Wen, Peidong Liu, Pengcui Li, Ziquan Yang   +8 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Repair Mechanisms for Microdamage in Bone [PDF]

Journal of Bone and Mineral Research, 2014
When Harold Frost first identifiedmicrodamage generated in vivo in bone, hewas referring only to linearmicrocracks that were discrete and whose edges could be identified microscopically. Whether these were real or artifactual was a source of debate for many years until, in the early 1990s, more than a few laboratories had observed them using Frost’s en
openaire   +2 more sources