Results 11 to 20 of about 326,067 (120)

Effect of Moderate Exercise on the Superficial Zone of Articular Cartilage in Age-Related Osteoarthritis

Diagnostics, 2023
This study aimed to evaluate the effect of exercise on the superficial zone of the osteoarticular cartilage during osteoarthritis progression. Three-month-old, nine-month-old, and eighteen-month-old Sprague Dawley rats were randomly divided into two ...
Yukun Yin, Yuanyu Zhang, Li Guo, Pengcui Li, Dongming Wang, Lingan Huang, Xiaoqin Zhao, Gaige Wu, Lu Li, Xiaochun Wei   +9 more
doaj   +1 more source

Bardoxolone methyl ameliorates osteoarthritis by inhibiting osteoclastogenesis and protecting the extracellular matrix against degradation

Heliyon, 2023
Inflammation and oxidative damage are closely related to the development of osteoarthritis. Bardoxolone methyl (CDDO-Me), a semisynthetic oleanane triterpenoid, plays a strong anti-inflammatory and antioxidant role.
Ruijia Yang, Yanjing Guo, Sujing Zong, Zhou Ma, Zhenyu Wang, Jiyu Zhao, Jinmei Yang, Liping Li, Chongwei Chen, Shaowei Wang   +9 more
doaj   +1 more source

Combination of chondrocytes and chondrons improves extracellular matrix production to promote the repairs of defective knee cartilage in rabbits

Journal of Orthopaedic Translation, 2021
Background: Chondrons are composed of chondrocytes and the surrounding pericellular matrix (PCM) and function to enhance chondrocyte-mediated cartilage tissue engineering.
Wangping Duan, Yu Zhao, Xiaochun Ren, Ruipeng Zhao, Qi Li, Zhenwei Sun, Wenjie Song, Yanfei Yang, Pengcui Li, Xiaochun Wei   +9 more
doaj   +1 more source

The association between three-dimensional measurement of posterior tilt angle in impacted femoral neck fractures and osteonecrosis of the femoral head

BMC Musculoskeletal Disorders, 2023
Background Hollow screw internal fixation is commonly used in clinical treatment of impacted femoral neck fractures. Previous studies have demonstrated a correlation between the preoperative posterior tilt angle of the femoral head and failure of ...
Bo Cong, Haiguang Zhang
doaj   +1 more source

Association rules analysis on patterns of multimorbidity in adults: based on the National Health and Nutrition Examination Surveys database

BMJ Open, 2022
Objective To explore the prevalence and patterns of multimorbidity in population with different genders and age ranges.Design A cross-sectional study.Setting National Health and Nutrition Examination Surveys database.Participants 12 576 patients.Primary ...
Lin Chen, Yangli Xie, Zheng Zheng, Junlan Huang, Xianding Sun, Ruobin Zhang   +5 more
doaj   +1 more source

Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect

Frontiers in Pharmacology, 2023
Background: Medication-related osteonecrosis of the jaw is a serious complication that develops in oncologic patients treated with Zoledronic acid. Although used for over 30 years, the influence of Zoledronic acid on bone has been thoroughly investigated,
Tal Berg, Tal Berg, Ofri Doppelt-Flikshtain, Ofri Doppelt-Flikshtain, Benjamin R. Coyac, Benjamin R. Coyac, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi   +8 more
doaj   +1 more source

Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway

Arthritis Research & Therapy, 2019
Background To determine if ipriflavone, a novel and safe inhibitor of Indian hedgehog (Ihh) signaling, can attenuate cartilage degeneration by blocking the Ihh pathway.
Li Guo, Xiaochun Wei, Zhiwei Zhang, Xiaojian Wang, Chunli Wang, Pengcui Li, Chunfang Wang, Lei Wei   +7 more
doaj   +1 more source

Autografts vs Synthetics for Cruciate Ligament Reconstruction: A Systematic Review and Meta‐Analysis

Orthopaedic Surgery, 2020
To describe the outcomes of autografts and synthetics in anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) reconstruction with respect to instrumented laxity measurements, patient‐reported outcome scores, complications, and graft ...
Jian Sun, Xiao‐chun Wei, Lu Li, Xiao‐ming Cao, Kai Li, Li Guo, Jian‐gong Lu, Zhi‐qing Duan, Chuan Xiang, Lei Wei   +9 more
doaj   +1 more source

Comparative clinical efficacy of “Figure-8” Banding and double-row anchor suture-bridge fixation in arthroscopic management of tibial intercondylar eminence avulsion fractures

Journal of Orthopaedic Surgery and Research
Objective The objective of this study is to assess and compare the clinical efficacy of “Figure-8” banding and double-row anchor suture-bridge fixation techniques in the arthroscopic management of tibial intercondylar eminence avulsion fractures.
Guo-Dong Zhang, Yue Zou, M. M. Xiu-Jiang Sun, Ke-Gui Liu, M. M. Wen-Qing Qu   +4 more
doaj   +1 more source

Soy isoflavones induces mitophagy to inhibit the progression of osteosarcoma by blocking the AKT/mTOR signaling pathway

Molecular Medicine
Background Soy isoflavones (SI) is a natural bioactive substance exhibiting beneficial effects on human health. This study aims to elucidate the therapeutic potential of SI in the treatment of osteosarcoma (OS) and to investigate the underlying ...
Ziang Zheng, Xinghan Zhao, Bo Yuan, Shan Jiang, Rushan Yan, Xiaowei Dong, Qijun Yao, Haidong Liang   +7 more
doaj   +1 more source