Results 11 to 20 of about 311,178 (265)

HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

BMC Musculoskeletal Disorders, 2022
Background The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA).
Xiaodong Gu, Fei Li, Yangyang Gao, Xianda Che, Pengcui Li   +4 more
doaj   +1 more source

α2-macroglobulin-rich serum as a master inhibitor of inflammatory factors attenuates cartilage degeneration in a mini pig model of osteoarthritis induced by “idealized” anterior cruciate ligament reconstruction

Frontiers in Pharmacology, 2022
Post-traumatic osteoarthritis is a special type of osteoarthritis and a common disease, with few effective treatments available. α2-Macroglobulin (α2M) is important to chondral protection in post-traumatic osteoarthritis.
Ruipeng Zhao, Xiaochun Wei, Chengming Zhang, Hongru Wu, Chuan Xiang, Haoqian Li, Wangping Duan, Zhiqing Duan, Chunjiang Li, Yu Zhao, Lingan Huang, Lingan Huang   +11 more
doaj   +1 more source

Effect of Moderate Exercise on the Superficial Zone of Articular Cartilage in Age-Related Osteoarthritis

Diagnostics, 2023
This study aimed to evaluate the effect of exercise on the superficial zone of the osteoarticular cartilage during osteoarthritis progression. Three-month-old, nine-month-old, and eighteen-month-old Sprague Dawley rats were randomly divided into two ...
Yukun Yin, Yuanyu Zhang, Li Guo, Pengcui Li, Dongming Wang, Lingan Huang, Xiaoqin Zhao, Gaige Wu, Lu Li, Xiaochun Wei   +9 more
doaj   +1 more source

The repair of bone [PDF]

Journal of British Surgery, 1919
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Gallie, W. E., Robertson, D. E.
openaire   +1 more source

Bardoxolone methyl ameliorates osteoarthritis by inhibiting osteoclastogenesis and protecting the extracellular matrix against degradation

Heliyon, 2023
Inflammation and oxidative damage are closely related to the development of osteoarthritis. Bardoxolone methyl (CDDO-Me), a semisynthetic oleanane triterpenoid, plays a strong anti-inflammatory and antioxidant role.
Ruijia Yang, Yanjing Guo, Sujing Zong, Zhou Ma, Zhenyu Wang, Jiyu Zhao, Jinmei Yang, Liping Li, Chongwei Chen, Shaowei Wang   +9 more
doaj   +1 more source

Combination of chondrocytes and chondrons improves extracellular matrix production to promote the repairs of defective knee cartilage in rabbits

Journal of Orthopaedic Translation, 2021
Background: Chondrons are composed of chondrocytes and the surrounding pericellular matrix (PCM) and function to enhance chondrocyte-mediated cartilage tissue engineering.
Wangping Duan, Yu Zhao, Xiaochun Ren, Ruipeng Zhao, Qi Li, Zhenwei Sun, Wenjie Song, Yanfei Yang, Pengcui Li, Xiaochun Wei   +9 more
doaj   +1 more source

Bone repair and stem cells [PDF]

Current Opinion in Genetics & Development, 2016
Bones are an important component of vertebrates; they grow explosively in early life and maintain their strength throughout life. Bones also possess amazing capabilities to repair-the bone is like new without a scar after complete repair. In recent years, a substantial progress has been made in our understanding on mammalian bone stem cells.
Noriaki, Ono, Henry M, Kronenberg
openaire   +2 more sources

The association between three-dimensional measurement of posterior tilt angle in impacted femoral neck fractures and osteonecrosis of the femoral head

BMC Musculoskeletal Disorders, 2023
Background Hollow screw internal fixation is commonly used in clinical treatment of impacted femoral neck fractures. Previous studies have demonstrated a correlation between the preoperative posterior tilt angle of the femoral head and failure of ...
Bo Cong, Haiguang Zhang
doaj   +1 more source

Association rules analysis on patterns of multimorbidity in adults: based on the National Health and Nutrition Examination Surveys database

BMJ Open, 2022
Objective To explore the prevalence and patterns of multimorbidity in population with different genders and age ranges.Design A cross-sectional study.Setting National Health and Nutrition Examination Surveys database.Participants 12 576 patients.Primary ...
Lin Chen, Yangli Xie, Zheng Zheng, Junlan Huang, Xianding Sun, Ruobin Zhang   +5 more
doaj   +1 more source

Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect

Frontiers in Pharmacology, 2023
Background: Medication-related osteonecrosis of the jaw is a serious complication that develops in oncologic patients treated with Zoledronic acid. Although used for over 30 years, the influence of Zoledronic acid on bone has been thoroughly investigated,
Tal Berg, Tal Berg, Ofri Doppelt-Flikshtain, Ofri Doppelt-Flikshtain, Benjamin R. Coyac, Benjamin R. Coyac, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi   +8 more
doaj   +1 more source