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Mechanisms of bone development and repair

Nature Reviews Molecular Cell Biology, 2020
Bone development occurs through a series of synchronous events that result in the formation of the body scaffold. The repair potential of bone and its surrounding microenvironment - including inflammatory, endothelial and Schwann cells - persists throughout adulthood, enabling restoration of tissue to its homeostatic functional state.
Ankit Salhotra, Harsh N Shāh, Benjamin Levi   +2 more
exaly   +4 more sources

Inflammation, fracture and bone repair [PDF]

Bone, 2016
The reconstitution of lost bone is a subject that is germane to many orthopedic conditions including fractures and non-unions, infection, inflammatory arthritis, osteoporosis, osteonecrosis, metabolic bone disease, tumors, and periprosthetic particle-associated osteolysis. In this regard, the processes of acute and chronic inflammation play an integral
Florence Loi, Jukka Pajarinen, Tzu-Hua Lin   +2 more
exaly   +4 more sources

Characteristics and Clinical Outcomes After Osteochondral Allograft Transplantation for Treating Articular Cartilage Defects: Systematic Review and Single-Arm Meta-analysis of Studies From 2001 to 2020

Orthopaedic Journal of Sports Medicine, 2023
Background: Osteochondral allograft transplantation (OCA) treats symptomatic focal cartilage defects with satisfactory clinical results. Purpose: To comprehensively analyze the characteristics and clinical outcomes of OCA for treating articular cartilage
Xueding Wang MMed, Zhiyuan Ren MMed, Yang Liu MMed, Yongsheng Ma MMed, Lingan Huang MD, Wenjie Song MMed, Qitai Lin MMed, Zhipeng Zhang MMed, Pengcui Li MD, Xiaochun Wei MD, Wangping Duan MD   +10 more
doaj   +1 more source

FTY720 Attenuates LPS-Induced Inflammatory Bone Loss by Inhibiting Osteoclastogenesis via the NF-κB and HDAC4/ATF Pathways

Journal of Immunology Research, 2023
Osteoclast (OC) abnormalities lead to many osteolytic diseases, such as osteoporosis, inflammatory bone erosion, and tumor-induced osteolysis. Exploring effective strategies to remediate OCs dysregulation is essential.
Chongwei Chen, Sujing Zong, Zhenyu Wang, Ruijia Yang, Yanjing Guo, Yunfei Wang, Xinping Chen, Yue Li, Shaowei Wang   +8 more
doaj   +1 more source

Upregulated ribosome pathway plays a key role in HDAC4, improving the survival rate and biofunction of chondrocytes

Bone & Joint Research, 2023
Aims: To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis. Methods: Empty adenovirus (EP) and a HDAC4 overexpression adenovirus were transfected into cultured human chondrocytes.
Li Guo, Hua Guo, Yuanyu Zhang, Zhi Chen, Jian Sun, Gaige Wu, Yunfei Wang, Yang Zhang, Xiaochun Wei, Pengcui Li   +9 more
doaj   +1 more source

Inhibition of aberrant Hif1α activation delays intervertebral disc degeneration in adult mice

Bone Research, 2022
The intervertebral disc (IVD) is the largest avascular tissue. Hypoxia-inducible factors (HIFs) play essential roles in regulating cellular adaptation in the IVD under physiological conditions. Disc degeneration disease (DDD) is one of the leading causes
Zuqiang Wang, Hangang Chen, Qiaoyan Tan, Junlan Huang, Siru Zhou, Fengtao Luo, Dali Zhang, Jing Yang, Can Li, Bo Chen, Xianding Sun, Liang Kuang, Wanling Jiang, Zhenhong Ni, Quan Wang, Shuai Chen, Xiaolan Du, Di Chen, Chuxia Deng, Liangjun Yin, Lin Chen, Yangli Xie   +21 more
doaj   +1 more source

Exploring the displacement characteristics of Garden III femoral neck fractures and the reliability, validity, and value of the anteroposterior Garden Index in assessing displacement severity

Journal of Orthopaedic Surgery and Research, 2023
Background Femoral neck fractures represent a significant public health concern, particularly in the elderly population. A thorough understanding and assessment of these fractures are deemed essential for optimal treatment and management.
Bo Cong, Ziyin Han, Haiguang Zhang
doaj   +1 more source

Prevention of sclerosis around cannulated screw after treatment of femoral neck fractures with bioceramic nails: a finite element analysis

BMC Musculoskeletal Disorders, 2023
Purpose Conventional cannulated screws (CS) are the main treatment method for femoral neck fractures (FNF). However, the rate of femoral head necrosis remains high after FNF treatment.
Yang Liu, Yugang Xing, Huifeng Shao, Xiaogang Wu, Yongsheng Ma, Wenming Yang, Qitai Lin, Pengcui Li, Yong He, Wangping Duan, Xiaochun Wei   +10 more
doaj   +1 more source

Gait Analysis of Bilateral Knee Osteoarthritis and Its Correlation with Western Ontario and McMaster University Osteoarthritis Index Assessment

Medicina, 2022
Background and objectives: Objective, accurate, and intuitive evaluation of knee joint function in patients with knee osteoarthritis (KOA) is important.
Haoqian Li, Shuai Hu, Ruipeng Zhao, Yixuan Zhang, Lingan Huang, Junjun Shi, Pengcui Li, Xiaochun Wei   +7 more
doaj   +1 more source

The repair of bone [PDF]

Journal of British Surgery, 1919
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Gallie, W. E., Robertson, D. E.
openaire   +1 more source