Results 11 to 20 of about 300,859 (269)

Bardoxolone methyl ameliorates osteoarthritis by inhibiting osteoclastogenesis and protecting the extracellular matrix against degradation

Heliyon, 2023
Inflammation and oxidative damage are closely related to the development of osteoarthritis. Bardoxolone methyl (CDDO-Me), a semisynthetic oleanane triterpenoid, plays a strong anti-inflammatory and antioxidant role.
Ruijia Yang, Yanjing Guo, Sujing Zong, Zhou Ma, Zhenyu Wang, Jiyu Zhao, Jinmei Yang, Liping Li, Chongwei Chen, Shaowei Wang   +9 more
doaj   +1 more source

Inflammation, fracture and bone repair [PDF]

Bone, 2016
The reconstitution of lost bone is a subject that is germane to many orthopedic conditions including fractures and non-unions, infection, inflammatory arthritis, osteoporosis, osteonecrosis, metabolic bone disease, tumors, and periprosthetic particle-associated osteolysis. In this regard, the processes of acute and chronic inflammation play an integral
Loi, Florence, Córdova Jara, Luis, Pajarinen, Jukka, Lin, Tzu-hua, Yao, Zhenyu, Goodman, Stuart B.   +5 more
openaire   +3 more sources

Combination of chondrocytes and chondrons improves extracellular matrix production to promote the repairs of defective knee cartilage in rabbits

Journal of Orthopaedic Translation, 2021
Background: Chondrons are composed of chondrocytes and the surrounding pericellular matrix (PCM) and function to enhance chondrocyte-mediated cartilage tissue engineering.
Wangping Duan, Yu Zhao, Xiaochun Ren, Ruipeng Zhao, Qi Li, Zhenwei Sun, Wenjie Song, Yanfei Yang, Pengcui Li, Xiaochun Wei   +9 more
doaj   +1 more source

The association between three-dimensional measurement of posterior tilt angle in impacted femoral neck fractures and osteonecrosis of the femoral head

BMC Musculoskeletal Disorders, 2023
Background Hollow screw internal fixation is commonly used in clinical treatment of impacted femoral neck fractures. Previous studies have demonstrated a correlation between the preoperative posterior tilt angle of the femoral head and failure of ...
Bo Cong, Haiguang Zhang
doaj   +1 more source

Association rules analysis on patterns of multimorbidity in adults: based on the National Health and Nutrition Examination Surveys database

BMJ Open, 2022
Objective To explore the prevalence and patterns of multimorbidity in population with different genders and age ranges.Design A cross-sectional study.Setting National Health and Nutrition Examination Surveys database.Participants 12 576 patients.Primary ...
Lin Chen, Yangli Xie, Zheng Zheng, Junlan Huang, Xianding Sun, Ruobin Zhang   +5 more
doaj   +1 more source

Bone repair and stem cells [PDF]

Current Opinion in Genetics & Development, 2016
Bones are an important component of vertebrates; they grow explosively in early life and maintain their strength throughout life. Bones also possess amazing capabilities to repair-the bone is like new without a scar after complete repair. In recent years, a substantial progress has been made in our understanding on mammalian bone stem cells.
Noriaki, Ono, Henry M, Kronenberg
openaire   +2 more sources

Oral fibroblasts rescue osteogenic differentiation of mesenchymal stem cells after exposure to Zoledronic acid in a paracrine effect

Frontiers in Pharmacology, 2023
Background: Medication-related osteonecrosis of the jaw is a serious complication that develops in oncologic patients treated with Zoledronic acid. Although used for over 30 years, the influence of Zoledronic acid on bone has been thoroughly investigated,
Tal Berg, Tal Berg, Ofri Doppelt-Flikshtain, Ofri Doppelt-Flikshtain, Benjamin R. Coyac, Benjamin R. Coyac, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi, Hadar Zigdon-Giladi   +8 more
doaj   +1 more source

Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway

Arthritis Research & Therapy, 2019
Background To determine if ipriflavone, a novel and safe inhibitor of Indian hedgehog (Ihh) signaling, can attenuate cartilage degeneration by blocking the Ihh pathway.
Li Guo, Xiaochun Wei, Zhiwei Zhang, Xiaojian Wang, Chunli Wang, Pengcui Li, Chunfang Wang, Lei Wei   +7 more
doaj   +1 more source

Development of bone canaliculi during bone repair

Bone, 2000
We recently found that silver impregnation staining with protargol (silver protein), that is, a modified Bodian method, is useful for histologically identifying the details of bone canaliculi structure, using thin sections of decalcified bone tissues. With this staining method, we conducted the present study to assess the development of bone canaliculi
K, Kusuzaki, N, Kageyama, H, Shinjo, H, Takeshita, H, Murata, S, Hashiguchi, T, Ashihara, Y, Hirasawa   +7 more
openaire   +2 more sources

Autografts vs Synthetics for Cruciate Ligament Reconstruction: A Systematic Review and Meta‐Analysis

Orthopaedic Surgery, 2020
To describe the outcomes of autografts and synthetics in anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) reconstruction with respect to instrumented laxity measurements, patient‐reported outcome scores, complications, and graft ...
Jian Sun, Xiao‐chun Wei, Lu Li, Xiao‐ming Cao, Kai Li, Li Guo, Jian‐gong Lu, Zhi‐qing Duan, Chuan Xiang, Lei Wei   +9 more
doaj   +1 more source