Results 31 to 40 of about 300,859 (269)

GOLGB1 deficiency accelerates intervertebral disc degeneration by activating the MAPK pathway

Scientific Reports
Intervertebral disc degeneration (IDD) is a multifactorially regulated age-related condition. Golgin B1 (GOLGB1) is a large Golgi-related transmembrane protein encoded by golgb1 gene.
Jingyuan Tian, Zhiquan Wang, Ruxing Liu, Xiaoting Qiu, Dongqin He, Nan Shan, Qichao Li, Guanghui He, Bin Zhao, Jie Yuan, Yongfeng Wang   +10 more
doaj   +1 more source

A new device and method for detecting the permeability of articular cartilage

Frontiers in Bioengineering and Biotechnology
ObjectiveArticular cartilage relies on synovial fluid for substance exchange, with permeability being a key parameter linked to its physiological functions and degenerative disease mechanisms.
Fuyang Cao, Fuyang Cao, Haibin Deng, Haibin Deng, Guohao Zhang, Guohao Zhang, Ningning Ma, Ningning Ma, Binghang Zhang, Binghang Zhang, Xianda Che, Xianda Che, Gaige Wu, Gaige Wu, Pengcui Li, Pengcui Li, Li Guo, Li Guo, Xiaochun Wei, Xiaochun Wei   +19 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

miR-135a Reduces Osteosarcoma Pulmonary Metastasis by Targeting Both BMI1 and KLF4

Frontiers in Oncology, 2021
Because of the modest response rate after surgery and chemotherapy, treatment of osteosarcoma (OS) remains challenging due to tumor recurrence and metastasis. miR-135a has been reported to act as an anticarcinogenic regulator of several cancers. However,
Chenglong Chen, Chenglong Chen, Xingjia Mao, Caitong Cheng, Yurui Jiao, Yi Zhou, Tingting Ren, Tingting Ren, Zhuangzhuang Wu, Zhi Lv, Xiaojuan Sun, Wei Guo, Wei Guo   +12 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Integrated proteomics and metabolomics analysis of sclerosis-related proteins and femoral head necrosis following internal fixation of femoral neck fractures

Scientific Reports
Femoral head necrosis (FHN) is a serious complication after femoral neck fractures (FNF), often linked to sclerosis around screw paths. Our study aimed to uncover the proteomic and metabolomic underpinnings of FHN and sclerosis using integrated ...
Yang Liu, Yongsheng Ma, Wenming Yang, Qitai Lin, Yugang Xing, Huifeng Shao, Pengcui Li, Yong He, Wangping Duan, Xiaochun Wei   +9 more
doaj   +1 more source

Substituted hydroxyapatites for bone repair

Journal of Materials Science: Materials in Medicine, 2012
Calcium phosphates such as hydroxyapatite have a wide range of applications both in bone grafts and for the coating of metallic implants, largely as a result of their chemical similarity to the mineral component of bone. However, to more accurately mirror the chemistry, various substitutions, both cationic (substituting for the calcium) and anionic ...
Jennifer H, Shepherd, David V, Shepherd, Serena M, Best   +2 more
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Deficient gait function despite effect index of the Western Ontario and McMaster university osteoarthritis index score considered cured one year after bilateral total knee arthroplasty

BMC Musculoskeletal Disorders
Background To clarify the value of gait analysis and its consistency with traditional scoring scales for the evaluation of knee joint function after total knee arthroplasty (TKA). Methods This study included 25 patients with knee osteoarthritis (KOA) who
Ruipeng Zhao, Xiaochun Wei, Shuai Hu, Yixuan Zhang, Hongru Wu, Pengcui Li, Yu Zhao   +6 more
doaj   +1 more source

Gut microbiota and fecal metabolic signatures in rat models of disuse-induced osteoporosis

Frontiers in Cellular and Infection Microbiology, 2022
BackgroundAssessing the correlation between gut microbiota (GM) and bone homeostasis has increasingly attracted research interest. Meanwhile, GM dysbiosis has been found to be associated with abnormal bone metabolism.
Xiaochen Qiao, Xiaochen Qiao, Xiaochen Qiao, Kun Zhang, Kun Zhang, Xiaoyan Li, Zhi Lv, Zhi Lv, Wenhao Wei, Wenhao Wei, Ruhao Zhou, Ruhao Zhou, Lei Yan, Lei Yan, Yongchun Pan, Sen Yang, Xiaojuan Sun, Xiaojuan Sun, Pengcui Li, Pengcui Li, Chaojian Xu, Chaojian Xu, Yi Feng, Yi Feng, Zhi Tian, Zhi Tian   +25 more
doaj   +1 more source