The Bone resorption assay provides an easy to use protocol for quantitatively measuring in vitro osteoclast-mediated bone resorption. Osteoclasts can be seeded onto the bone slices and formation of resorption pits can be quantified via toluidinblue ...
Carina Scholtysek+2 more
doaj +4 more sources
Mechanisms of Bone Resorption in Periodontitis [PDF]
Alveolar bone loss is a hallmark of periodontitis progression and its prevention is a key clinical challenge in periodontal disease treatment. Bone destruction is mediated by the host immune and inflammatory response to the microbial challenge. However, the mechanisms by which the local immune response against periodontopathic bacteria disturbs the ...
Stefan A. Hienz+2 more
openaire +6 more sources
Experimental model in vivo for quantitative assessment of bone resorption inhibition [PDF]
Quantitative assessment of bone resorption inhibition in vivo is not easily accomplished; methods relying on a count of osteoclasts are questionable, and histomorphometric evaluation of the bone mass presents several technical problems as well.
Ugo E. Pazzaglia+4 more
openalex +3 more sources
Roles of hyaluronan in bone resorption [PDF]
Background Hyaluronan, an unsulfated glycosaminoglycan, while being closely linked to osteoclast function several years ago, has received little attention lately. Given recent new knowledge of hyaluronan's possible cell binding abilities, it is important
Prince Charles W
doaj +4 more sources
An In Vitro Model of Murine Osteoclast-Mediated Bone Resorption [PDF]
Osteoclasts are terminally differentiated multinucleated giant cells that mediate bone resorption and regulate skeletal homeostasis under physiological and pathological states.
Xiaoyue Sun+4 more
doaj +2 more sources
Local mechanical stimuli regulate bone formation and resorption in mice at the tissue level. [PDF]
Bone is able to react to changing mechanical demands by adapting its internal microstructure through bone forming and resorbing cells. This process is called bone modeling and remodeling.
Friederike A Schulte+6 more
doaj +2 more sources
Roles of Toll-like Receptor Signaling in Inflammatory Bone Resorption [PDF]
Toll-like receptors (TLRs) are pattern recognition receptors expressed in immune cells, including neutrophils, macrophages, and dendritic cells. Microbe-associated molecular patterns, including bacterial components, membranes, nucleic acids, and flagella
Tsukasa Tominari+12 more
doaj +2 more sources
Autophagy Regulator Rufy 4 Promotes Osteoclastic Bone Resorption by Orchestrating Cytoskeletal Organization via Its RUN Domain [PDF]
Rufy4, a protein belonging to the RUN and FYVE domain-containing protein family, participates in various cellular processes such as autophagy and intracellular trafficking. However, its role in osteoclast-mediated bone resorption remains uncertain.
Eiko Sakai+6 more
doaj +2 more sources
Osteoclast-derived apoptotic bodies couple bone resorption and formation in bone remodeling
Bone remodeling is precisely coordinated by bone resorption and formation. Apoptotic osteoclasts generate large amounts of apoptotic bodies (ABs) marking the end of the bone resorption phase, whereas the functions of osteoclast-derived ABs remain largely
Qinyu Ma+7 more
semanticscholar +1 more source
Relationship between the Height of Alveolar Bone Resorption and Sex and Age in Adolescents
ObjectiveTo explore the relationship between the height of alveolar bone resorption and sex and age in the adolescent dentition.MethodsMulti-slice computed tomography (MSCT) was used to measure the height of alveolar bone resorption at labial, lingual ...
MA Jing-jing+7 more
doaj +1 more source