Autophagy Regulator Rufy 4 Promotes Osteoclastic Bone Resorption by Orchestrating Cytoskeletal Organization via Its RUN Domain [PDF]
Rufy4, a protein belonging to the RUN and FYVE domain-containing protein family, participates in various cellular processes such as autophagy and intracellular trafficking. However, its role in osteoclast-mediated bone resorption remains uncertain.
Eiko Sakai+6 more
doaj +2 more sources
Relationship between the Height of Alveolar Bone Resorption and Sex and Age in Adolescents
ObjectiveTo explore the relationship between the height of alveolar bone resorption and sex and age in the adolescent dentition.MethodsMulti-slice computed tomography (MSCT) was used to measure the height of alveolar bone resorption at labial, lingual ...
MA Jing-jing+7 more
doaj +1 more source
Ammonia-induced Calcium Phosphate Nanostructure: A Potential Assay for Studying Osteoporosis and Bone Metastasis [PDF]
Osteoclastic resorption of bone plays a central role in both osteoporosis and bone metastasis. A reliable in vitro assay that simulates osteoclastic resorption in vivo would significantly speed up the process of devel-oping effective therapeutic solutions for those diseases. Here we reported the development of a novel and robust nano-structured calcium
arxiv +1 more source
Adaptive bone-remodeling theory applied to prosthetic-design analysis [PDF]
The subject of this article is the development and application of computer-simulation methods to predict stress-related adaptive bone remodeling, in accordance with ‘Wolff's Law’.
Dalstra, M.+5 more
core +11 more sources
The Mechanism Switching the Osteoclast From Short to Long Duration Bone Resorption
The current models of osteoclastic bone resorption focus on immobile osteoclasts sitting on the bone surface and drilling a pit into the bone matrix.
Jean-Marie Delaisse+11 more
doaj +1 more source
Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption
The process of bone remodeling is the result of the regulated balance between bone cell populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte, the mechanosensory cell type.
H. Kitaura+9 more
semanticscholar +1 more source
Independent of cathepsin K, the osteoclast-derived matrix metalloproteinases MMP9 and MMP14 codependently drive bone resorption. Codependent deconstruction Bone homeostasis encompasses a balancing act between formation of new bone and remodeling and ...
Lingxin Zhu+7 more
semanticscholar +1 more source
Random walk models for the propagation of signalling molecules in one-dimensional spatial networks and their continuum limit [PDF]
The propagation of signalling molecules within cellular networks is affected by network topology, but also by the spatial arrangement of cells in the networks. Understanding the collective reaction--diffusion behaviour in space of signals propagating through cellular networks is an important consideration for example for regenerative signals that ...
arxiv +1 more source
Bone Resorption Stimulation involves initiation of absorption and removal of the hard connective tissue that constitutes the vertebrate skeleton and consists of a matrix of collagenous fibers impregnated chiefly with calcium phosphate and calcium ...
semanticscholar +1 more source
Effects of a mesoporous bioactive glass on osteoblasts, osteoclasts and macrophages [PDF]
A mesoporous bioactive glass (MBG) of molar composition 75SiO2-20CaO-5P2O5 (MBG-75S) has been synthetized as a potential bioceramic for bone regeneration purposes. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), nitrogen adsorption studies and transmission electron microscopy (TEM) demonstrated that MBG-75Spossess a highly ...
arxiv +1 more source