Results 21 to 30 of about 973,694 (311)

Postoperative Functional Assessment in Patients with Tumors Around the Knee Treated with Endoprosthetic Reconstruction: A Multicenter Retrospective Cohort Study

Technology in Cancer Research & Treatment, 2023
Objectives The restoration of as much normal function as possible has become an important goal following the endoprosthetic reconstruction. The objective of this study was to assess the functional outcome after endoprosthetic reconstruction for tumors ...
Yun-long Zhao MD, Hao-ran Zhang MD, Jing-yu Zhang MD, Yong-cheng Hu MD, PhD   +3 more
doaj   +1 more source

Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. [PDF]

, 2018
The myeloma bone marrow microenvironment promotes proliferation of malignant plasma cells and resistance to therapy. Activation of JAK/STAT signaling is thought to be a central component of these microenvironment-induced phenotypes.
Aftab, Blake T, Ferguson, Ian D, Hann, Byron C, Lam, Christine, Lin, Yu-Hsiu T, Liu, Hui, Liu, Jun O, Mariano, Margarette C, Mitsiades, Constantine S, Murnane, Megan, Smith, Geoffrey A, Taunton, Jack, Wiita, Arun P, Wong, Sandy W   +13 more
core   +2 more sources

Anlotinib Reverses Multidrug Resistance (MDR) in Osteosarcoma by Inhibiting P-Glycoprotein (PGP1) Function In Vitro and In Vivo

Frontiers in Pharmacology, 2022
Overexpression of the multidrug resistance (MDR)-related protein P-glycoprotein (PGP1), which actively extrudes chemotherapeutic agents from cells and significantly decreases the efficacy of chemotherapy, is viewed as a major obstacle in osteosarcoma ...
Gangyang Wang, Gangyang Wang, Lingling Cao, Yafei Jiang, Yafei Jiang, Tao Zhang, Tao Zhang, Hongsheng Wang, Hongsheng Wang, Zhuoying Wang, Zhuoying Wang, Jing Xu, Jing Xu, Min Mao, Min Mao, Yingqi Hua, Yingqi Hua, Zhengdong Cai, Zhengdong Cai, Xiaojun Ma, Xiaojun Ma, Shuo Hu, Shuo Hu, Chenghao Zhou, Chenghao Zhou   +24 more
doaj   +1 more source

Benign Bone Tumors

Radiologic Clinics of North America, 2011
A solid knowledge of underlying histopathology of benign bone tumors aids in differential diagnoses of these tumors. Important factors in diagnosis of a bone tumor include patient age and gender; the bone involved; the location of the tumor along, within, or on the bone; lesion margin; matrix proliferation; and periosteal reaction.
Motamedi, Kambiz, Seeger, Leanne L
openaire   +4 more sources

The prognostic value of C-X-C motif chemokine receptor 4 in patients with sporadic malignant peripheral nerve sheath tumors

Chinese Journal of Cancer, 2017
Background Recent studies indicate that C-X-C motif chemokine receptor 4 (CXCR4) and its ligand, C-X-C motif chemokine ligand 12 (CXCL12), stimulate expression of the cell cycle regulatory protein Cyclin D1 in neurofibromatosis 1-associated malignant ...
Chao Zhang, Fang-Yuan Chang, Wen-Ya Zhou, Ji-Long Yang   +3 more
doaj   +1 more source

Time and dose dependency of bone-sarcomas in patients injected with radium-224 [PDF]

, 1988
The time course and dose dependency of the incidence of bone-sarcomas among 900 German patients treated with high doses of radium-224 is analysed in terms of a proportional hazards model with a log-normal dependency of time to tumor and a linear ...
A. M. Kellerer, C. E. Land, C. W. Mays, CE Land, Committee on the biological effects of ionizing radiations, CW Mays, CW Mays, CW Mays, CW Mays, D Chmelevsky, D. Chmelevsky, H Spiess, H. Spiess, JS Spratt, RR Wick   +14 more
core   +1 more source

Liquid-liquid phase separation drives immune signaling transduction in cancer: a bibliometric and visualized study from 1992 to 2024

Frontiers in Oncology
BackgroundLiquid–liquid phase separation (LLPS) is a novel concept that could explain how living cells precisely modulate internal spatial and temporal functions.
Yanhong Pei, Haijie Liang, Yu Guo, Boyang Wang, Han Wu, Zhijian Jin, Shanyi Lin, Fanwei Zeng, Yifan Wu, Qianyu Shi, Jiuhui Xu, Yi Huang, Tingting Ren, Jiarui Liu, Jiarui Liu, Wei Guo   +15 more
doaj   +1 more source

The role of mesh technology with tumor prosthesis reconstruction to reconstruct the extensor mechanism of knee joint after resection of proximal tibial tumors

Journal of Orthopaedic Surgery and Research, 2019
Purpose The aim of this study was to evaluate the role of mesh technique in the reconstruction of the extensor mechanism after resection of proximal tibial tumors.
Bin Liu, Jia Chang Tan, Hui Lin Wang, Zhenjie Wu, Zhen Chao Yuan, Chang Yuan Wei   +5 more
doaj   +1 more source

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. [PDF]

, 2017
MicroRNAs (miRNAs) have emerged as key players in cancer progression and metastatic initiation yet their importance in regulating prostate cancer (PCa) metastasis to bone has begun to be appreciated.
Colden, Melissa, Dahiya, Priya V, Dahiya, Rajvir, Dar, Altaf A, Majid, Shahana, Saini, Sharanjot, Shahryari, Varahram, Stein, Gary, Tanaka, Yuichiro, Yamamura, Soichiro   +9 more
core   +2 more sources

Two-year follow-up of unilateral biportal endoscopy assisted extraforaminal lumbar interbody fusion: how to perform indirect decompression and fusion under endoscopy: a retrospective study in Japan [PDF]

Asian Spine Journal
Study Design Retrospective study. Purpose To compare the clinical and radiographic outcomes of unilateral biportal endoscopy-assisted extraforaminal lumbar interbody fusion (BE-ELIF) and oblique lateral interbody fusion (OLIF).
Takaki Yoshimizu, Sanshiro Saito, Teruaki Miyake, Tetsutaro Mizuno, Ushio Nosaka, Keisuke Ishii, Mizuki Watanabe, Kanji Sasaki   +7 more
doaj   +1 more source