Results 51 to 60 of about 94,944 (270)

Intranasal acellular pertussis vaccine provides mucosal immunity and protects mice from Bordetella pertussis

npj Vaccines, 2019
Current acellular pertussis vaccines fall short of optimal protection against the human respiratory pathogen Bordetella pertussis resulting in increased incidence of a previously controlled vaccine- preventable disease.
Dylan T. Boehm, Allison Wolf, Jesse M. Hall, T. Wong, Emel Sen-Kilic, M. A. Wolf, Hayden Basinger, Sebastian A. Dziadowicz, M. P. Gutierrez, C. Blackwood, Shelby D. Bradford, Katherine A. Begley, William T. Witt, M. Varney, M. Barbier, F. Damron   +15 more
semanticscholar   +1 more source

Genome-based prediction of cross-protective, HLA-DR-presented epitopes as putative vaccine antigens for multiple Bordetella species

Microbiology Spectrum
Acellular pertussis vaccines protect against severe pertussis, but vaccine-induced immunity wanes over time. Prior animal studies showed that T-cell responses are integral to long-lasting immunity.
Muktha S. Natrajan, Jesse M. Hall, Michael R. Weigand, Yanhui Peng, Margaret M. Williams, Mohamed Momin, Frederick Heath Damron, Purnima Dubey, Maria Lucia Tondella, Lucia C. Pawloski   +9 more
doaj   +1 more source

The Role of the Aceullular Pertussis Vaccine and the Comeback of 'Pertussis Pete'?

Canadian Journal of Infectious Diseases, 2001
Pertussis or whooping cough is an acute infectious disease of the respiratory tract caused principally by Bordetella pertussis and less commonly by Bordetella parapertussis (1).
John M Conly, B Lynn Johnston
doaj   +1 more source

Pertussis in the Association of Southeast Asian Nations: epidemiology and challenges

International Journal of Infectious Diseases, 2019
Pertussis is a highly infectious respiratory disease caused by Bordetella pertussis. Infants and young children are particularly at risk of severe and life-threatening disease. Infectious older individuals may transmit Bordetella pertussis to unprotected
Usa Thisyakorn, Terapong Tantawichien, Chule Thisyakorn, Philippe Buchy   +3 more
doaj   +1 more source

A novel method for the extraction of outer membrane vesicles (OMVs) from Bordetella pertussis Tohama strain

Iranian Journal of Microbiology, 2020
Background and Objectives: There are many pertussis outbreaks which is mainly due to the reduction in the immunity of acellular pertussis (aP) vaccines. Therefore, there is a crucial necessity to develop a new generation of pertussis vaccine.
Mohammad Sekhavati, Ashraf Mohabati Mobarez, Seyed Davar Siadat, Mojtaba Noofeli   +3 more
doaj   +1 more source

Differential and Temporal Immunomodulation of alpha4 Integrins on CD4+ Memory Cells by Bordetella pertussis and Bordetella parapertussis [PDF]

, 2012
Pertussis, caused by Bordetella pertussis (B. pertussis), is reemerging worldwide due to vaccine inefficacy. The hallmarks of infection are extreme lymphocytosis and delayed recovery, which are partially associated with pertussis toxin.
Ravindra, Dipti
core   +1 more source

Swedish Infants Developed Pertussis at a Younger Age if Their Mother Was the Possible Source of Infection in 2009–2015

Acta Paediatrica, EarlyView.
ABSTRACT Aim The aim of this study was to investigate the possible source of laboratory‐confirmed pertussis in infants under 6 months of age. Methods This nationwide prospective study was based on laboratory‐confirmed cases reported in the enhanced pertussis surveillance in Sweden from 2009 to 2015. The parents or carers of 345 infants were interviewed
Bernice Aronsson, Lennart Nilsson, Jann Storsaeter, Henrik Källberg, Emma Appelqvist   +4 more
wiley   +1 more source

Seroprevalence of IgA and IgM antibodies to Bordetella pertussis in healthy Japanese donors: Assessment for the serological diagnosis of pertussis.

PLoS ONE, 2019
Pertussis is a human respiratory infection caused by the gram-negative bacterium, Bordetella pertussis. To evaluate the pertussis burden and vaccine efficacy, diagnosis and epidemiological surveillance should be based on accurate and valid diagnostic ...
Rei Fumimoto, Nao Otsuka, Hajime Kamiya, Tomimasa Sunagawa, Keiko Tanaka-Taya, Kazunari Kamachi, Keigo Shibayama   +6 more
doaj   +1 more source

Comparison of Bordetella species identification among differing rt-PCR assays in the United States

Microbiology Spectrum
In the United States, the general laboratory method for diagnosing pertussis, caused by Bordetella pertussis, is real-time PCR (rt-PCR) targeting insertion sequence 481 (IS481).
Matthew Cole, Ashley K. Simon, Amanda Faulkner, Tami Skoff, Maria L. Tondella, Clemente Montero, Melinda B. Nye, Margaret Williams   +7 more
doaj   +1 more source

The Eukaryotic Host Factor 14-3-3 Inactivates Adenylate Cyclase Toxins of Bordetella bronchiseptica and B. parapertussis, but Not B. pertussis

mBio, 2018
Bordetella pertussis, Bordetella bronchiseptica, and Bordetella parapertussis share highly homologous virulence factors and commonly cause respiratory infections in mammals; however, their host specificities and disease severities differ, and the reasons
Aya Fukui-Miyazaki, Hirono Toshima, Yukihiro Hiramatsu, Keisuke Okada, Keiji Nakamura, Keisuke Ishigaki, Naoaki Shinzawa, Hiroyuki Abe, Yasuhiko Horiguchi   +8 more
doaj   +1 more source