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Human Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany [PDF]

Emerging Microbes and Infections, 2022
In 2021, three encephalitis cases due to the Borna disease virus 1 (BoDV-1) were diagnosed in the north and east of Germany. The patients were from the states of Thuringia, Saxony-Anhalt, and Lower Saxony.
Christina Frank, Jonathan Wickel, Dirk Brämer, Jakob Matschke, Richard Ibe, Caroline Gazivoda, Albrecht Günther, Christian Hartmann, Kordt Rehn, Daniel Cadar, Thomas E. Mayer, Kirsten Pörtner, Hendrik Wilking, Jonas Schmidt-Chanasit, Dennis Tappe   +14 more
doaj   +3 more sources

Healthcare-associated exposure to Borna disease virus 1 (BoDV-1) [PDF]

Journal of Occupational Medicine and Toxicology, 2022
The Borna disease virus 1 (BoDV-1) causes severe and often fatal encephalitis in humans. The virus is endemic in parts of Germany, Liechtenstein, Switzerland and Austria.
Judith Reinmiedl, Heiko Schulz, Viktoria C. Ruf, Moritz R. Hernandez Petzsche, Jürgen Rissland, Dennis Tappe   +5 more
doaj   +3 more sources

Reverse Genetics and Artificial Replication Systems of Borna Disease Virus 1 [PDF]

Viruses, 2022
Borna disease virus 1 (BoDV-1) is a neurotropic RNA virus belonging to the family Bornaviridae within the order Mononegavirales. Whereas BoDV-1 causes neurological and behavioral disorders, called Borna disease (BD), in a wide range of mammals, its ...
Takehiro Kanda, Keizo Tomonaga
doaj   +3 more sources

Molecular epidemiology of human Borna disease virus 1 infection revisited [PDF]

Emerging Microbes and Infections, 2022
Borna disease virus 1 (BoDV-1) strains attracted public interest by recently reported rare fatal encephalitis cases in Germany. Previously, human BoDV-1 infection was suggested to contribute to psychiatric diseases.
Liv Bode, Yujie Guo, Peng Xie
doaj   +3 more sources

Investigation of fatal human Borna disease virus 1 encephalitis outside the previously known area for human cases, Brandenburg, Germany – a case report [PDF]

BMC Infectious Diseases, 2021
Background The true burden and geographical distribution of human Borna disease virus 1 (BoDV-1) encephalitis is unknown. All detected cases so far have been recorded in Bavaria, southern Germany.
Dennis Tappe, Kirsten Pörtner, Christina Frank, Hendrik Wilking, Arnt Ebinger, Christiane Herden, Christoph Schulze, Birgit Muntau, Petra Eggert, Petra Allartz, Gerlind Schuldt, Jonas Schmidt-Chanasit, Martin Beer, Dennis Rubbenstroth   +13 more
doaj   +3 more sources

IFN-γ-Based ELISpot as a New Tool to Detect Human Infections with Borna Disease Virus 1 (BoDV-1): A Pilot Study [PDF]

Viruses, 2023
More than 40 human infections with the zoonotic Borna disease virus 1 (BoDV-1) have been reported to German health authorities from endemic regions in southern and eastern Germany.
Lisa Eidenschink, Gertrud Knoll, Dennis Tappe, Robert Offner, Thomas Drasch, Yvonne Ehrl, Bernhard Banas, Miriam C Banas, Hans Helmut Niller, André Gessner, Josef Köstler, Benedikt M J Lampl, Matthias Pregler, Melanie Völkl, Jürgen Kunkel, Bernhard Neumann, Klemens Angstwurm, Barbara Schmidt, Markus Bauswein   +18 more
doaj   +3 more sources

Lethal Borna disease virus 1 infections of humans and animals – in-depth molecular epidemiology and phylogeography [PDF]

Nature Communications
Borna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored white-toothed shrew (Crocidura leucodon)
Arnt Ebinger, Pauline D. Santos, Florian Pfaff, Ralf Dürrwald, Jolanta Kolodziejek, Kore Schlottau, Viktoria Ruf, Friederike Liesche-Starnecker, Armin Ensser, Klaus Korn, Reiner Ulrich, Jenny Fürstenau, Kaspar Matiasek, Florian Hansmann, Torsten Seuberlich, Daniel Nobach, Matthias Müller, Antonie Neubauer-Juric, Marcel Suchowski, Markus Bauswein, Hans-Helmut Niller, Barbara Schmidt, Dennis Tappe, Daniel Cadar, Timo Homeier-Bachmann, Viola C. Haring, Kirsten Pörtner, Christina Frank, Lars Mundhenk, Bernd Hoffmann, Jochen Herms, Wolfgang Baumgärtner, Norbert Nowotny, Jürgen Schlegel, Rainer G. Ulrich, Martin Beer, Dennis Rubbenstroth   +36 more
doaj   +3 more sources

Prominent Efficacy of Amantadine against Human Borna Disease Virus Infection In Vitro and In Vivo. Comment on Fink et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses 2021, 13, 539 [PDF]

Viruses, 2022
Amantadine (1-amino-adamantane) is a versatile antiviral compound which has been licensed for decades against influenza viruses. During the Corona pandemic, its effect to inhibit SARS-CoV-2 in vitro has been investigated.
Liv Bode, Detlef E. Dietrich, Carsten W. Spannhuth, Hanns Ludwig   +3 more
doaj   +3 more sources

No evidence for European bats serving as reservoir for Borna disease virus 1 or other known mammalian orthobornaviruses [PDF]

Virology Journal, 2020
Background The majority of emerging infectious diseases are zoonotic in nature and originate from wildlife reservoirs. Borna disease, caused by Borna disease virus 1 (BoDV-1), is an infectious disease affecting mammals, but recently it has also been ...
Daniel Nobach, Christiane Herden
doaj   +3 more sources

Risk factors for Borna disease virus 1 encephalitis in Germany - a case-control study. [PDF]

Emerg Microbes Infect, 2023
In 2018, Borna Disease Virus 1 (BoDV-1) was confirmed as a human zoonotic pathogen causing rare but fatal encephalitis in Germany. While diagnostic procedures and the clinical picture have been described, epidemiology remains mysterious.
Pörtner K, Wilking H, Frank C, Böhmer MM, Stark K, Tappe D.   +5 more
europepmc   +2 more sources