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Human Borna disease virus 1 (BoDV-1) encephalitis cases in the north and east of Germany [PDF]

Emerging Microbes and Infections, 2022
In 2021, three encephalitis cases due to the Borna disease virus 1 (BoDV-1) were diagnosed in the north and east of Germany. The patients were from the states of Thuringia, Saxony-Anhalt, and Lower Saxony.
Christina Frank, Jonathan Wickel, Dirk Brämer, Jakob Matschke, Richard Ibe, Caroline Gazivoda, Albrecht Günther, Christian Hartmann, Kordt Rehn, Daniel Cadar, Thomas E. Mayer, Kirsten Pörtner, Hendrik Wilking, Jonas Schmidt-Chanasit, Dennis Tappe   +14 more
doaj   +9 more sources

IFN-γ-Based ELISpot as a New Tool to Detect Human Infections with Borna Disease Virus 1 (BoDV-1): A Pilot Study [PDF]

Viruses, 2023
More than 40 human infections with the zoonotic Borna disease virus 1 (BoDV-1) have been reported to German health authorities from endemic regions in southern and eastern Germany.
Lisa Eidenschink, Gertrud Knoll, Dennis Tappe, Robert Offner, Thomas Drasch, Yvonne Ehrl, Bernhard Banas, Miriam C Banas, Hans Helmut Niller, André Gessner, Josef Köstler, Benedikt M J Lampl, Matthias Pregler, Melanie Völkl, Jürgen Kunkel, Bernhard Neumann, Klemens Angstwurm, Barbara Schmidt, Markus Bauswein   +18 more
doaj   +8 more sources

Is vaccination a feasible public health strategy against fatal Borna disease virus 1 (BoDV-1) encephalitis? An epidemiological perspective. [PDF]

PLoS Pathogens
Human Borna disease virus 1 (BoDV-1) encephalitis is characterized by rapid clinical progression, an absence of a causal therapy and an extremely high case fatality rate.
Kirsten Pörtner, Christina Frank, Hendrik Wilking, Klaus Stark, Christiane Herden, Martin Beer, Dennis Rubbenstroth, Dennis Tappe   +7 more
doaj   +8 more sources

Healthcare-associated exposure to Borna disease virus 1 (BoDV-1) [PDF]

Journal of Occupational Medicine and Toxicology, 2022
The Borna disease virus 1 (BoDV-1) causes severe and often fatal encephalitis in humans. The virus is endemic in parts of Germany, Liechtenstein, Switzerland and Austria.
Judith Reinmiedl, Heiko Schulz, Viktoria C. Ruf, Moritz R. Hernandez Petzsche, Jürgen Rissland, Dennis Tappe   +5 more
doaj   +5 more sources

Low prevalence of Borna disease virus 1 (BoDV-1) IgG antibodies in humans from areas endemic for animal Borna disease of Southern Germany. [PDF]

Sci Rep, 2019
Borna disease virus-1 (BoDV-1) was recently discovered as cause of severe and often fatal encephalitis in humans. BoDV-1 is known to cause neurological disease in horses and sheep mainly in South and Central Germany.
Tappe D, Frank C, Offergeld R, Wagner-Wiening C, Stark K, Rubbenstroth D, Giese S, Lattwein E, Schwemmle M, Beer M, Schmidt-Chanasit J, Wilking H.   +11 more
europepmc   +9 more sources

Lethal Borna disease virus 1 infections of humans and animals – in-depth molecular epidemiology and phylogeography [PDF]

Nature Communications
Borna disease virus 1 (BoDV-1) is the causative agent of Borna disease, a fatal neurologic disorder of domestic mammals and humans, resulting from spill-over infection from its natural reservoir host, the bicolored white-toothed shrew (Crocidura leucodon)
Arnt Ebinger, Pauline D. Santos, Florian Pfaff, Ralf Dürrwald, Jolanta Kolodziejek, Kore Schlottau, Viktoria Ruf, Friederike Liesche-Starnecker, Armin Ensser, Klaus Korn, Reiner Ulrich, Jenny Fürstenau, Kaspar Matiasek, Florian Hansmann, Torsten Seuberlich, Daniel Nobach, Matthias Müller, Antonie Neubauer-Juric, Marcel Suchowski, Markus Bauswein, Hans-Helmut Niller, Barbara Schmidt, Dennis Tappe, Daniel Cadar, Timo Homeier-Bachmann, Viola C. Haring, Kirsten Pörtner, Christina Frank, Lars Mundhenk, Bernd Hoffmann, Jochen Herms, Wolfgang Baumgärtner, Norbert Nowotny, Jürgen Schlegel, Rainer G. Ulrich, Martin Beer, Dennis Rubbenstroth   +36 more
doaj   +8 more sources

Magnetic resonance imaging of human variegated squirrel bornavirus 1 (VSBV-1) encephalitis reveals diagnostic pattern indistinguishable from Borna disease virus 1 (BoDV-1) encephalitis but typical for bornaviruses [PDF]

Emerging Microbes and Infections, 2023
Human bornavirus encephalitis is an emerging disease caused by the variegated squirrel bornavirus 1 (VSBV-1) and the Borna disease virus 1 (BoDV-1).
Monika Huhndorf, Julia Juhasz, Mike P. Wattjes, Andreas Schilling, Stefan Schob, Ingmar Kaden, Günter Klaß, Dennis Tappe   +7 more
doaj   +5 more sources

Human Infections with Borna Disease Virus 1 (BoDV-1) Primarily Lead to Severe Encephalitis: Further Evidence from the Seroepidemiological BoSOT Study in an Endemic Region in Southern Germany [PDF]

Viruses, 2023
More than 40 human cases of severe encephalitis caused by Borna disease virus 1 (BoDV-1) have been reported to German health authorities. In an endemic region in southern Germany, we conducted the seroepidemiological BoSOT study (“BoDV-1 after solid ...
Markus Bauswein, Lisa Eidenschink, Gertrud Knoll, Bernhard Neumann, Klemens Angstwurm, Saida Zoubaa, Markus J Riemenschneider, Benedikt M J Lampl, Matthias Pregler, Hans Helmut Niller, Jonathan Jantsch, André Gessner, Yvonne Eberhardt, Gunnar Huppertz, Torsten Schramm, Stefanie Kühn, Michael Koller, Thomas Drasch, Yvonne Ehrl, Bernhard Banas, Robert Offner, Barbara Schmidt, Miriam C. Banas   +22 more
doaj   +5 more sources

First therapeutic drug monitoring of experimental favipiravir in Borna disease virus 1 (BoDV-1) encephalitis patients reveals significant gaps in antiviral treatment: a pilot investigation [PDF]

European Journal of Medical Research
Background The Borna disease virus 1 (BoDV-1) causes a rare, but severe form of encephalitis in Germany, characterized by rapid progression, late diagnosis, and a high case fatality. Therapy is experimental and recommendations are lacking.
Michael Paal, Katharina Habler, Alice Ewert, Michael Vogeser, Leonie Grosse, Victoria Lieftüchter, Simone C. Tauber, Johannes Schiefer, Petra Allartz, Dennis Tappe, Kirsten Pörtner   +10 more
doaj   +4 more sources

Increasing evidence of human infections by the neurotropic Borna disease virus 1 (BoDV-1) [PDF]

Virulence, 2023
Michaela Cain, Hinh Ly
doaj   +4 more sources