Results 1 to 10 of about 3,395,639 (199)

Analysis of boron neutron capture reaction sensitivity using Monte Carlo simulation and proposal of a new dosimetry index in boron neutron capture therapy. [PDF]

J Radiat Res, 2022
Abstract Boron neutron capture therapy is a cellular-scale heavy-particle therapy. The factor determining the biological effects in the boron neutron capture reaction (BNCR) is the value of ${\alpha}_{boron}$, which is the alpha component in the Linear Quadratic (LQ) model. Recently, the factor determining the value of ${\alpha}_{boron}$
Takeno S, Tanaka H, Ono K, Mizowaki T, Suzuki M.   +4 more
europepmc   +3 more sources

Experimental test of neutron intensity monitor with isomer production reaction for p-Li neutron source for boron neutron capture therapy

Frontiers in Nuclear Engineering
IntroductionBoron Neutron Capture Therapy (BNCT) is a promising cancer therapy. At present, development of accelerator based neutron source (ABNS) is underway to be utilized as a neutron source instead of nuclear reactor.
Shingo Tamaki, Yuuki Ohtani, Sachie Kusaka, Fuminobu Sato, Isao Murata   +4 more
doaj   +4 more sources

Effect of Rapamycin on the Radio-Sensitivity of Cultured Tumor Cells Following Boron Neutron Capture Reaction. [PDF]

World J Oncol, 2020
Mammalian target of rapamycin (mTOR) signaling pathway has been implicated in multiple mechanisms of resistance to anticancer drugs and poor treatment outcomes in various human cancers. Meanwhile, clinical boron neutron capture therapy (BNCT) has been carried out for patients with malignant gliomas, melanomas, inoperable head and neck tumors and oral ...
Tatebe H, Masunaga SI, Nishimura Y.
europepmc   +4 more sources

Potential targets for boron transport in boron neutron capture therapy [PDF]

Frontiers in Oncology
Boron Neutron Capture Therapy (BNCT) is a binary cancer therapy that involves boron (10B) drug administration and epithermal/thermal neutron irradiation. The nuclear fission reaction between low-energy thermal neutrons and 10B atoms accumulated in cancer
Yucai Wei, Yucai Wei, Yucai Wei, Weijing Zhu, Weijing Zhu, Qian Chen, Huda Alnufaei, Yumin Li, Yumin Li, Kate Ricketts   +9 more
doaj   +4 more sources

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy [PDF]

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +2 more sources

Nanocarrier Strategies for Boron Drug Delivery in BNCT [PDF]

Micromachines
Boron neutron capture therapy (BNCT) is a radiotherapeutic modality that enables tumor-targeted cell killing. The nuclear capture reaction between boron-10 (10B) and low-energy thermal neutrons produces high linear energy transfer (LET) particles (α ...
Sanjay Yadav, Efe Precious Onakpojeruo, Cedric Lansangan, Rameshwar Patil   +3 more
doaj   +2 more sources

Boron‐embedded multifunctional nanoplatform toward potential combined boron neutron capture therapy and immunomodulation in glioma [PDF]

Smart Molecules, EarlyView.
A brain‐targeting multifunctional nanoplatform (DM&Ce6@COF‐Ang) was engineered by employing boron‐enriched APTES‐COF‐1 as both the therapeutic boron agent and the nanocarrier co‐delivery of DMXAA and Ce6. This nanoplatform achieved synergistic tumor‐specific boron delivery, real‐time pharmacokinetic monitoring, and immunomodulation.
Yiming Liu, Xuejian Wang, Bangjian Li, Kun Shao, Jianlong Su, Yang Wang, Lin Cheng, Zhihao Wu, JinRong Li, Guanyi Zhang, Xu Wang, Yuxuan Zhang, Yuanhao Liu, Guangzhe Li   +13 more
wiley   +2 more sources

Minimally Invasive Cytoselective Radiation Therapy Using Boron Neutron Capture Reaction

Yakugaku Zasshi, 2010
The cell-killing effect of boron neutron capture therapy (BNCT) is due to the nuclear reaction of two essentially nontoxic species, boron-10 ((10)B) and thermal neutrons, whose destructive effect is well observed in boron-loaded tissues. High accumulation and selective delivery of boron into tumor tissue are the most important requirements to achieve ...
Hiroyuki Nakamura
exaly   +4 more sources

Investigation of photon doses reaching healthy tissues in the use of different neutron energies in boron neutron capture therapy [PDF]

Nuclear Technology and Radiation Protection, 2022
Boron neutron capture therapy is a unique treatment method that aims to kill the tumor cells with the help of heavy particles. Particles resulting from the interaction of the tumor region containing 10B atoms with thermal or epithermal neutrons ...
Tugrul Taylan
doaj   +1 more source

Construction of targeted 10B delivery agents and their uptake in gastric and pancreatic cancer cells

Frontiers in Oncology, 2023
Boron Neutron Capture Therapy (BNCT) is a new binary radiation therapy for tumor tissue, which kills tumor cells with neutron capture reaction. Boron neutron capture therapy has become a technical means for glioma, melanoma, and other diseases has been ...
Song Wang, Song Wang, Zhengchao Zhang, Zhengchao Zhang, Lele Miao, Lele Miao, Jiaxing Zhang, Jiaxing Zhang, Futian Tang, Futian Tang, Muzhou Teng, Muzhou Teng, Yumin Li, Yumin Li   +13 more
doaj   +1 more source