Results 31 to 40 of about 18,230 (257)

Rapid approach to complex boronic acids [PDF]

Science Advances, 2019
Nanoliter acoustic dispensing technology is an efficient way to synthesize large, diverse, and complex libraries of boronic acids.
Neochoritis, Constantinos G., Shaabani, Shabnam, Ahmadianmoghaddam, Maryam, Zarganes-Tzitzikas, Tryfon, Gao, Li, Novotná, Michaela, Mitríková, Tatiana, Romero, Atilio Reyes, Irianti, Marina Ika, Xu, Ruixue, Olechno, Joe, Ellson, Richard, Helan, Victoria, Kossenjans, Michael, Groves, Matthew R., Dömling, Alexander   +15 more
openaire   +3 more sources

Boronic acid-modified cell-penetrating peptide exhibits superior performance over natural TAT peptide

Frontiers in Chemical Biology
This study explores an enhancement to a cell-penetrating peptide (CPP), specifically cyclic deca arginine (cR10), by modifying it with boronic acid to improve the delivery efficiency of ubiquitin (Ub), an essential protein that plays various roles in ...
Pritam Ghosh
doaj   +1 more source

Cross-Coupling Synthesis of Methylallyl Alkenes: Scope Extension and Mechanistic Study

Molecules, 2015
Cross-coupling reactions between 2-methyl-2-propen-1-ol and various boronic acids are used to obtain aromatic-(2-methylallyl) derivatives. However, deboronation or isomerization side reactions may occur for several boronic acids.
Clémence Tabélé, Christophe Curti, Youssef Kabri, Nicolas Primas, Patrice Vanelle   +4 more
doaj   +1 more source

Potent Inhibition of Mandelate Racemase by Boronic Acids: Boron as a Mimic of a Carbon Acid Center

Biochemistry, 2020
Boronic acids have been successfully employed as inhibitors of hydrolytic enzymes. Typically, an enzymatic nucleophile catalyzing hydrolysis adds to the electrophilic boron atom forming a tetrahedral species that mimics the intermediate(s)/transition state(s) for the hydrolysis reaction.
Amar Nath Sharma, Lia Grandinetti, Erin R. Johnson, Martin St. Maurice, Stephen L. Bearne   +4 more
openaire   +3 more sources

Application of an R-group search technique in the molecular design of dipeptidyl boronic acid proteasome inhibitors [PDF]

Journal of the Serbian Chemical Society, 2017
In this work, a 3D-QSAR model involving for 40 dipeptidyl boronic acid proteasome inhibitors was built based on Topomer CoMFA. The multiple correlation coefficient of fitting, cross-validation and external validation were 0.908, 0.647 and 0.703 ...
Tong Jian-Bo, Li Yuan-Yuan, Jiang Guo-Yan, Li Kang-Nan   +3 more
doaj   +1 more source

Bortezomib is an effective enhancer for chemical probe-dependent superoxide detection

Frontiers in Medicine, 2022
Various chemical probes for the detection of reactive oxygen species have been developed to examine oxidative stress associated with different pathologies.
Misaki Matsumoto, Hikari Sawada, Kazumi Iwata, Masakazu Ibi, Nozomi Asaoka, Masato Katsuyama, Kaori Shintani-Ishida, Hiroshi Ikegaya, Shigehiko Takegami, Atsushi Umemura, Chihiro Yabe-Nishimura   +10 more
doaj   +1 more source

Designing Polymer Nanocomposites for X‐Ray Shielding: Mechanisms, Architectures, and Scalable Processing

Advanced Engineering Materials, EarlyView.
This review highlights advances in lightweight, lead‐free polymer nanocomposites for diagnostic X‐ray shielding. By linking filler chemistry, dispersion, architecture, and photon interaction mechanisms, it establishes structure–performance relationships guiding material design.
Aklilu G. Messele, Hossein Ipakchi, Tizazu H. Mekonnen   +2 more
wiley   +1 more source

(2,4,6-Trimethylphenyl)boronic acid–triphenylphosphine oxide (1/1)

Acta Crystallographica Section E, 2012
In the crystal structure of the title compound, C9H13BO2·C18H15OP, there are O—H...O hydrogen bonds between the O atom of triphenylphosphine oxide and one hydroxy group of the boronic acid. Boronic acid molecules form inversion-related
Sorin Roşca, Marian Olaru, Ciprian I. Raţ   +2 more
doaj   +1 more source

Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can
Mothana K. Al-Omari, Mai Elaarag, Raed M. Al-Zoubi, Ahmad R. Al-Qudimat, Ayman A. Zarour, Enas A. Al-Hurani, Zainab E. Fares, Leena M. Alkharraz, Mohanad Shkoor, Abdulilah D. Bani-Yaseen, Omar M. Aboumarzouk, Aksam Yassin, Abdulla A. Al-Ansari   +12 more
doaj   +1 more source

Defunctionalisation catalysed by boron Lewis acids

Chemical Science, 2020
The combination of boron Lewis acid catalysts and hydride sources enables the cleavage of various carbon–heteroatom bonds.
Huaquan Fang, Martin Oestreich
openaire   +3 more sources