Frontiers in Chemical BiologyThis study explores an enhancement to a cell-penetrating peptide (CPP), specifically cyclic deca arginine (cR10), by modifying it with boronic acid to improve the delivery efficiency of ubiquitin (Ub), an essential protein that plays various roles in ...
Pritam Ghosh
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Fingerprint profiling human gut microbiota through boronic acid-based sensor array and its application on colorectal cancer classification [PDF]
Nature CommunicationsThe interplay between gut microbiota and host plays a crucial role in human health and disease pathogenesis. However, current profiling methods for gut microbiota are costly, time-intensive and require specialized instrumentation.
Kuicheng Zhao +11 more
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Boronic acid inhibitors of penicillin-binding protein 1b: serine and lysine labelling agents [PDF]
Journal of Enzyme Inhibition and Medicinal ChemistryPenicillin-binding proteins (PBPs) contribute to bacterial cell wall biosynthesis and are targets of antibacterial agents. Here, we investigated PBP1b inhibition by boronic acid derivatives.
Levente Kollár +7 more
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Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications
Molecules, 2020 Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly due to the idea that this group could confer some toxicity. Nowadays, this concept has been demystified and, especially after the discovery of the drug bortezomib, the
Mariana Pereira Silva +3 more
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Synergistic Antibacterial Action of Norfloxacin-Encapsulated G4 Hydrogels: The Role of Boronic Acid and Cyclodextrin [PDF]
GelsIn this present study, we developed and characterized a series of supramolecular G4 hydrogels by integrating β-cyclodextrin (β-CD) and boronic acid linkers into a supramolecular matrix to enhance antibacterial activity against Staphylococcus aureus (S ...
Monica-Cornelia Sardaru +4 more
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Enhancing the Mechanical Properties of Injectable Nanocomposite Hydrogels by Adding Boronic Acid/Boronate Ester Dynamic Bonds at the Nanoparticle–Polymer Interface [PDF]
GelsIncorporating nanoparticles into injectable hydrogels is a well-known technique for improving the mechanical properties of these materials. However, significant differences in the mechanical properties of the polymer matrix and the nanoparticles can ...
Jesús Sánchez +6 more
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Electrochromic properties of monosubstituted benzylboronic acid viologen [PDF]
MATEC Web of Conferences, 2023 Synthesis of monosubstituted benzyl boronic acid viologen (mBBV) has been achieved. The boronic acid group in mBBV can form boronic ester bonds with the hydroxyl groups in polyvinyl alcohol (PVA), resulting in an all-in-one electrochromic gel.
Tang Shengwei, Niu Junlong, Jia Chunyang
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Bioactivity of boronic acid derivative homodimers
Results in Chemistry, 2022 Homodimers that deployed boronic acids and their esters in their termini, namely boronic acid derivative homodimers, were designed. The boronic acid pinacol ester homodimer displayed antiviral activity and the boronic acid homodimer, in contrast, exerted
Kaori Ota +7 more
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Reversible Recognition-Based Boronic Acid Probes for Glucose Detection in Live Cells and Zebrafish
Journal of the American Chemical Society, 2023 Glucose, a critical source of energy, directly determines the homeostasis of the human body. However, due to the lack of robust imaging probes, the mechanism underlying the changes of glucose homeostasis in the human body remains unclear.
Kai Wang +16 more
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Inorganics, 2023 It has been demonstrated that different organoboron compounds interact with some well-known molecular targets, including serine proteases, transcription factors, receptors, and other important molecules.
Miguel Ortiz-Flores +7 more
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