Results 21 to 30 of about 37,334 (332)

A simple generic method for analyzing water sensitive pinacol boronate compounds by hydrophilic interaction liquid chromatography

Journal of Chromatography Open, 2022
Pinacol boronates are widely used in the pharmaceutical and biomedical industries as primary building blocks for many chemical reactions, such as Suzuki coupling.
Lulu Dai, Joseph Gonzalez, Kelly Zhang
doaj   +1 more source

Anticancer-active 3,4-diarylthiolated maleimides synthesis via three-component radical diarylthiolation

Frontiers in Chemistry, 2022
Herein, we report an efficient and simple copper-catalyzed oxidative diarylthiolation of maleimides with sulfur powder and aryl boronic acids, in which S powder was used as a substrate and internal oxidant.
Limei Wang, Zhuo Li, Zhehan Ma, Kedi Xia, Wenyu Wang, Wenchang Yu   +5 more
doaj   +1 more source

Boronic Acids and Their Derivatives in Medicinal Chemistry: Synthesis and Biological Applications

Molecules, 2020
Boron containing compounds have not been widely studied in Medicinal Chemistry, mainly due to the idea that this group could confer some toxicity. Nowadays, this concept has been demystified and, especially after the discovery of the drug bortezomib, the
Mariana Pereira Silva, Lucília Saraiva, Madalena Pinto, Maria Emília Sousa   +3 more
doaj   +1 more source

Boronic Acids as Prospective Inhibitors of Metallo-β-Lactamases: Efficient Chemical Reaction in the Enzymatic Active Site Revealed by Molecular Modeling

Molecules, 2021
Boronic acids are prospective compounds in inhibition of metallo-β-lactamases as they form covalent adducts with the catalytic hydroxide anion in the enzymatic active site upon binding.
Alexandra V. Krivitskaya, Maria G. Khrenova   +1 more
doaj   +1 more source

Cross-Coupling Synthesis of Methylallyl Alkenes: Scope Extension and Mechanistic Study

Molecules, 2015
Cross-coupling reactions between 2-methyl-2-propen-1-ol and various boronic acids are used to obtain aromatic-(2-methylallyl) derivatives. However, deboronation or isomerization side reactions may occur for several boronic acids.
Clémence Tabélé, Christophe Curti, Youssef Kabri, Nicolas Primas, Patrice Vanelle   +4 more
doaj   +1 more source

Highly Diastereo- and Enantioselective Allylboration of Aldehydes using alpha-Substituted Allyl/Crotyl Pinacol Boronic Esters via in Situ Generated Borinic Esters [PDF]

, 2013
Readily available, alpha-substituted allyl/crotyl pinacol boronic esters often give low E/Z selectivity (with Z favored) in reactions with aldehydes. We found that addition of nBuLi to the pinacol boronic ester followed by trapping of the alkoxide with ...
Althaus M., Andersen M. W., Batey R. A., Batey R. A., Beckmann E., Blais J., Brown H. C., Brown H. C., Brown H. C., Brown H. C., Bubnov Y. N., Carosi L., Carosi L., Chemler S. R., Chen M., Chen M., Christine L. Willis, Cmrecki V., Cole T. E., Denmark S. E., Fang G. Y., Flamme E. M., Gonzalez A. Z., Guzman-Martinez A., Hancock K. G., Helen K. Scott, Hesse M. J., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Hoffmann R. W., Ito H., Jack L.-Y. Chen, Kennedy J. W. J., Kister J., Kliman L. T., Kramer G. W., Lachance H., Larouche-Gauthier R., Matteson D. S., Matthew J. Hesse, Midland M. M., Park J. K., Pelz N. F., Peng F., Peng F., Pietruszka J., Pietruszka J., Posseme F., Pulis A., Ramachandran P. V., Shiner C. S., Sonawane R. P., Stymiest J. L., Varinder K. Aggarwal, Webster M. P., Woodward A. R., Yamamoto Y., Zschage O.   +60 more
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The Active Site Sulfenic Acid Ligand in Nitrile Hydratases Can Function as a Nucleophile [PDF]

, 2014
Nitrile hydratase (NHase) catalyzes the hydration of nitriles to their corresponding commercially valuable amides at ambient temperatures and physiological pH.
Holz, Richard C., Liu, Dali, Martinez, Salette, Sanishvili, Ruslan, Wu, Rui   +4 more
core   +3 more sources

Microwave-mediated synthesis of N-methyliminodiacetic acid (MIDA) boronates [PDF]

, 2014
A library of over 20, mainly aryl or heteroaryl, N-methyliminodiacetic acid (MIDA) boronates have been synthesised. A rapid microwave-mediated (MW) method (5–10 min) has been developed using polyethylene glycol 300 (PEG 300) as solvent.
Close, Adam J, Emmerson, Matthew K, Kemmitt, Paul, Spencer, John   +3 more
core   +1 more source

Synthesis of substituted benzooxaborinin-1-ols via palladium-catalysed cyclisation of alkenyl- and alkynyl-boronic acids [PDF]

, 2016
Two new palladium-catalysed reactions have been developed for the synthesis of stable 4-substituted benzooxaborinin-1-ols. A palladium-catalysed cyclisation of ortho-alkenylbenzene boronic acids can be used to access 4-chlorobenzooxaborinin-1-ols via a ...
Aliev, AE, Benhamou, L, Bucar, DK, Sheppard, TD, Walker, D   +4 more
core   +1 more source

Covalent adaptable networks using boronate linkages by incorporating TetraAzaADamantanes

Frontiers in Chemistry, 2023
Boronic esters prepared by condensation of boronic acids and diols have been widely used as dynamic covalent bonds in the synthesis of both discrete assemblies and polymer networks.
Simon van Hurne, Marijn Kisters, Maarten M. J. Smulders   +2 more
doaj   +1 more source