Results 81 to 90 of about 11,886 (207)

Acute Toxicity of Aqueous Extract from Bredemeyera floribunda Root Bark in an Animal Model

The Scientific World Journal, Volume 2024, Issue 1, 2024.
The medicinal plant Bredemeyera floribunda Willd. is used to treat cardiovascular disease, chronic fatigue, low libido, as well as increased diuresis. However, studies considering the toxicity of this plant are scarce. Develop an aqueous extract of B. floribunda considering traditional use and determine the average lethality (LD50), signs, and symptoms
Cláudia Stela Medeiros, Beatriz Medeiros, Maria Lígia Macedo, Rita Guimarães, Karine Freitas, Danielle Bogo, Priscila Hiane, Ricardo Viana, Valter Nascimento, Santiago Garcia-Granda   +9 more
wiley   +1 more source

Chronic kidney failure following lancehead bite envenoming: a clinical report from the Amazon region [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases
Background: Snakebite envenoming can be a life-threatening condition, for which emergency care is essential. The Bothrops (lancehead) genus is responsible for most snakebite-related deaths and permanent loss of function in human victims in Latin America.
Manuela B. Pucca, Michelle V. S. Franco, Jilvando M. Medeiros, Isadora S. Oliveira, Shirin Ahmadi, Felipe A. Cerni, Umberto Zottich, Bruna K. Bassoli, Wuelton M. Monteiro, Andreas H. Laustsen   +9 more
doaj   +2 more sources

Cytotoxic and inflammatory potential of a phospholipase A2 from Bothrops jararaca snake venom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2018
BackgroundSnake venom phospholipases A2 (PLA2s) have been reported to induce myotoxic, neurotoxic, hemolytic, edematogenic, cytotoxic and proinflammatory effects.
Rafhaella C A Cedro, Danilo L Menaldo, T. R. Costa, K. F. Zoccal, M. A. Sartim, N. Santos-Filho, L. Faccioli, S. Sampaio   +7 more
semanticscholar   +1 more source

Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms.

PLoS ONE, 2019
BACKGROUND:It is known that local tissue injuries incurred by snakebites are quickly instilled causing extensive, irreversible, tissue destruction that may include loss of limb function or even amputation.
Marcelo A Strauch, Marcelo Amorim Tomaz, Marcos Monteiro-Machado, Bruno Lemos Cons, Fernando Chagas Patrão-Neto, Jhonatha da Mota Teixeira-Cruz, Matheus da Silva Tavares-Henriques, Pâmella Dourila Nogueira-Souza, Sara L S Gomes, Paulo R R Costa, Edgar Schaeffer, Alcides J M da Silva, Paulo A Melo   +12 more
doaj   +1 more source

Rutin (quercetin-3-rutinoside) modulates the hemostatic disturbances and redox imbalance induced by Bothrops jararaca snake venom in mice

PLoS Neglected Tropical Diseases, 2018
Snakebites are a major Collective Health problem worldwide. In Brazil, Bothrops jararaca snake venom (BjV) evokes hemostatic disturbances, bleeding manifestations, and redox status imbalance.
A. Sachetto, J. G. Rosa, M. Santoro
semanticscholar   +1 more source

Venom Composition of Neglected Bothropoid Snakes from the Amazon Rainforest: Ecological and Toxinological Implications

Toxins
Snake venoms have evolved in several families of Caenophidae, and their toxins have been assumed to be biochemical weapons with a role as a trophic adaptation.
Luciana A. Freitas-de-Sousa, Mônica Colombini, Vinicius C. Souza, Joanderson P. C. Silva, Ageane Mota-da-Silva, Marllus R. N. Almeida, Reginaldo A. Machado, Wirven L. Fonseca, Marco A. Sartim, Jacqueline Sachett, Solange M. T. Serrano, Inácio L. M. Junqueira-de-Azevedo, Felipe G. Grazziotin, Wuelton M. Monteiro, Paulo S. Bernarde, Ana M. Moura-da-Silva   +15 more
doaj   +1 more source

Effects of Two Fractions of Swietenia macrophylla and Catechin on Muscle Damage Induced by BothropsVenom and PLA2

Toxins, 2019
Plant natural products can attenuate the myonecrosis caused by Bothrops snake venom and their phospholipases A2 (PLA2). In this study, we evaluated the effects of two fractions (F4 and F6) from Swietenia macrophylla and purified catechin on the muscle ...
Silvia Posada Arias, Berardo de Jesús Rodríguez, Tatiana Lobo-Echeverri, Raphael Shezaro Ramos, Stephen Hyslop, VitelbinaNúñez Rangel   +5 more
doaj   +1 more source

Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergón) Induces Glycoprotein VI Shedding and Impairs Platelet Function

Molecules, 2019
Atroxlysin-III (Atr-III) was purified from the venom of Bothrops atrox. This 56-kDa protein bears N-linked glycoconjugates and is a P-III hemorrhagic metalloproteinase.
L. Oliveira, M. Estevão-Costa, V. Alvarenga, D. Vivas-Ruiz, A. Yarlequé, A. M. Lima, A. Cavaco, J. Eble, E. Sanchez   +8 more
semanticscholar   +1 more source

A Preliminary, Multicenter, Prospective and Real World Study on the Hemostasis, Coagulation, and Safety of Hemocoagulase Bothrops Atrox in Patients Undergoing Transurethral Bipolar Plasmakinetic Prostatectomy

Frontiers in Pharmacology, 2019
Objective: To evaluate the hemostasis and coagulation effect of Hemocoagulase Bothrops Atrox in benign prostatic hyperplasia (BPH) patients undergoing transurethral bipolar plasmakinetic prostatectomy (TUPKP).
Bing-hui Li, Zhaohua Yu, Chao-yang Wang, Hao Zi, Xiaodong Li, Xing-huan Wang, Xuan-Yi Ren, Tong-Zu Liu, Hang Zheng   +8 more
semanticscholar   +1 more source

Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A2 and mediates its toxic activity

Scientific Reports, 2018
Phospholipases A2 are a major component of snake venoms. Some of them cause severe muscle necrosis through an unknown mechanism. Phospholipid hydrolysis is a possible explanation of their toxic action, but catalytic and toxic properties of PLA2s are not ...
M. Massimino, M. Simonato, B. Spolaore, C. Franchin, G. Arrigoni, O. Marin, Laura Monturiol-Gross, Julián Fernández, B. Lomonte, Fiorella Tonello   +9 more
semanticscholar   +1 more source