Bleeding Disorders in Bothrops atrox Envenomations in the Brazilian Amazon: Participation of Hemostatic Factors and the Impact of Tissue Factor [PDF]
Toxins, 2020 Bleeding is a common hemostatic disorder that occurs in Bothrops envenomations. We evaluated the changes in coagulation, fibrinolysis components, and platelets in Bothrops atrox envenomations with bleeding. This is an observational study with B.
Sâmella S. Oliveira +16 more
doaj +2 more sources
Experimental Bothrops atrox envenomation: Efficacy of antivenom therapy and the combination of Bothrops antivenom with dexamethasone. [PDF]
PLoS Neglected Tropical Diseases, 2017 Bothrops atrox snakes are the leading cause of snake bites in Northern Brazil. The venom of this snake is not included in the antigen pool used to obtain the Bothrops antivenom. There are discrepancies in reports on the effectiveness of this antivenom to
Gabriella Neves Leal Santos Barreto +7 more
doaj +2 more sources
Experimental Bothrops atrox Envenomation: Blood Plasma Proteome Effects after Local Tissue Damage and Perspectives on Thromboinflammation [PDF]
Toxins, 2022 The clinical manifestations of Bothrops atrox envenoming involve local and systemic changes, among which edema requires substantial attention due to its ability to progress to compartmental syndromes and sometimes cause tissue loss and amputations ...
Joeliton S. Cavalcante +9 more
doaj +2 more sources
Acute toxic effects of Bothrops atrox venom on calcium homeostasis and bone tissue in mice [PDF]
Toxicon: XBothrops atrox is a terrestrial pit viper inhabiting the Amazon region. The venom of B. atrox acts almost immediately at the site of the bite, leading to significant tissue damage, but also affects different organs.
Hatem Kallel +9 more
doaj +2 more sources
Snake Venom Protease Detection and Inhibition in Serum. [PDF]
ChemMedChemA fluorescence assay enables sensitive detection of the activities of snake venom metalloproteases (SVMP) and serine proteases (SVSP) from viper venoms in buffer and serum. In combination with effective low‐molecular‐weight inhibitors such as ilomastat and nafamostat, this approach offers new prospects for the rapid diagnosis and adjunctive therapy of ...
Riedel M, Kersten C.
europepmc +2 more sources
Acute compartment syndrome in Bothrops atrox envenomation: a case-control study in the Brazilian Amazon [PDF]
Journal of Venomous Animals and Toxins including Tropical DiseasesBackground: Bothrops snakebite is common in the Amazon region and can lead to severe complications in the affected limb, including secondary bacterial infections, blisters, necrosis, and acute compartment syndrome (ACS) in extreme cases.
Glenda de Oliveira Batista do Nascimento +7 more
doaj +2 more sources
Individual Variability in Bothrops atrox Snakes Collected from Different Habitats in the Brazilian Amazon: New Findings on Venom Composition and Functionality [PDF]
Toxins, 2021 Differences in snake venom composition occur across all taxonomic levels and it has been argued that this variation represents an adaptation that has evolved to facilitate the capture and digestion of prey and evasion of predators.
Leijane F. Sousa +8 more
doaj +2 more sources
Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergón) Induces Glycoprotein VI Shedding and Impairs Platelet Function [PDF]
Molecules, 2019 Atroxlysin-III (Atr-III) was purified from the venom of Bothrops atrox. This 56-kDa protein bears N-linked glycoconjugates and is a P-III hemorrhagic metalloproteinase.
Luciana S. Oliveira +8 more
doaj +2 more sources
A Preliminary, Multicenter, Prospective and Real World Study on the Hemostasis, Coagulation, and Safety of Hemocoagulase Bothrops Atrox in Patients Undergoing Transurethral Bipolar Plasmakinetic Prostatectomy [PDF]
Frontiers in Pharmacology, 2019 Objective: To evaluate the hemostasis and coagulation effect of Hemocoagulase Bothrops Atrox in benign prostatic hyperplasia (BPH) patients undergoing transurethral bipolar plasmakinetic prostatectomy (TUPKP).Methods: This study adopted a multicenter ...
Bing-Hui Li +11 more
doaj +2 more sources
Revista Peruana de Medicina Experimental y Salud Pública, 2020 Objectives: To evaluate the capacity of the hyperimmune llama serum (Lama glama) to neutralize the lethal activity of Bothrops atrox venom in laboratory mice.
Henri Bailon Calderon +11 more
doaj +1 more source