Results 161 to 170 of about 8,168 (216)

Study on the synthesis and structure-activity relationship of 1,2,3-triazoles against toxic activities of Bothrops jararaca venom

Zeitschrift für Naturforschung C - A Journal of Biosciences, 2022
Snakebite envenoming is a health concern and has been a neglected tropical disease since 2017, according to the World Health Organization. In this study, we evaluated the ability of ten 1,2,3-triazole derivatives AM001 to AM010 to inhibit pertinent in ...
Jenifer Frouche de Souza, Marcos V. S. Santana, A. C. D. da Silva, M. R. H. Donza, V. Ferreira, S. Ferreira, E. Sanchez, H. Castro, A. Fuly   +8 more
semanticscholar   +1 more source

Pharmacological evidence for a presynaptic action of venoms from Bothrops insularis (jararaca ilhoa) and Bothrops neuwiedi (jararaca pintada)

Toxicon, 2004
Whereas the presynaptic action of Crotalus durissus terrificus venom is well-established, Bothrops venoms have historically been considered to have only postsynaptic and muscular effects. However, some studies have also suggested a presynaptic action for these venoms. In this work, we used chick biventer cervicis preparations to compare the presynaptic
Léa, Rodrigues-Simioni, Stella R, Zamunér, José C, Cogo, Caroline R, Borja-Oliveira, Júlia, Prado-Franceschi, Maria Alice, da Cruz-Höfling, Alexandre P, Corrado   +6 more
openaire   +2 more sources

Reducing time in lethality assay (LD50) for Bothrops jararaca and Crotalus durissus terrificus venoms and lethality neutralizing assay (ED50) for their respective antivenoms: A 3Rs-based retrospective data validation.

Toxicon
Mouse lethality assays (MLA) remain the gold standard for evaluating antivenom potency despite ethical concerns regarding animal welfare. This study assessed whether reducing observation periods from 48 to 24 h in MLA for determining median lethal dose ...
A. Pereira-Júnior, F. Lima, I. F. Martins, Renan de Souza Fructuoso da Silva, E. Lucas   +4 more
semanticscholar   +1 more source

The distinct N-terminomes of Bothrops jararaca newborn and adult venoms.

Biochimica et Biophysica Acta - Proteins and Proteomics, 2021
Using approaches of transcriptomics and proteomics we have shown that the phenotype of Bothrops jararaca venom undergoes a significant rearrangement upon neonate to adult transition.
Débora Andrade-Silva, M. Nishiyama, D. Stuginski, A. Zelanis, S. Serrano   +4 more
semanticscholar   +1 more source

Jararaca GPIb-binding protein from Bothrops jararaca snake venom induces intense thrombocytopenia in mice.

Toxicon
Snakes of the genus Bothrops are responsible for most snakebites in Latin America, frequently associated with hemostatic disorders. Among venom components, C-type lectin-like proteins (CTLPs) stand out for their ability to interact with platelet ...
A. Torres, Natacha Ferreira de Oliveira, Eduardo Oliveira Venâncio de Lima, A. Tanaka-Azevedo, M. L. Santoro   +4 more
semanticscholar   +1 more source

Seasonal Activity of Bothrops jararaca (Serpentes, Viperidae): Optimizing Foraging while Avoiding Predators

South American Journal of Herpetology, 2021
. The peak of activity of Bothrops jararaca is in the rainy season. This pitviper feeds mainly on small mammals and is preyed upon by several avian and mammal predators.
L. H. Siqueira, Karina Banci, O. A. Marques   +2 more
semanticscholar   +1 more source

Purification and characterization of two fibrinolytic enzymes from Bothrops jararaca (jararaca) venom

Toxicon, 1992
Two fibrinolytic enzymes, jararafibrase I and jararafibrase II, were purified from Bothrops jararaca venom. The purified jararafibrase I and jararafibrase II ran as single protein bands on analytical polyacrylamide gel electrophoresis and had mol. wts of 47,000 +/- 2000 and 21,400 +/- 500, respectively, by SDS-polyacrylamide gel electrophoresis.
M, Maruyama, M, Sugiki, E, Yoshida, H, Mihara, N, Nakajima   +4 more
openaire   +2 more sources

An in-depth snake venom proteopeptidome characterization: Benchmarking Bothrops jararaca.

Journal of Proteomics, 2017
A large-scale proteomic approach was devised to advance the understanding of venom composition. Bothrops jararaca venom was fractionated by OFFGEL followed by chromatography, generating peptidic and proteic fractions.
C. Nicolau, P. Carvalho, I. Junqueira-de-Azevedo, A. Teixeira-Ferreira, M. Junqueira, J. Perales, A. Neves-Ferreira, R. H. Valente   +7 more
semanticscholar   +2 more sources

Purification and some characteristics of a zinc metalloprotease from the venom of Bothrops jararaca (jararaca)

Toxicon, 1989
A metalloprotease from Bothrops jararaca venom (J protease) was purified by DEAE-Sephacel, CM-cellulose, Sephacryl S-200 and Sephadex G-75 chromatograph. The proteolytic activity was inactivated by EDTA, o-phenanthroline and DTNB. Phosphoramidon and cysteine protease inhibitors (leupeptin, E64 and its derivatives) were inactive on this enzyme.
M M, Tanizaki, R B, Zingali, H, Kawazaki, S, Imajoh, S, Yamazaki, K, Suzuki   +5 more
openaire   +2 more sources

Isolation and characterization of a proteolytic enzyme from the venom of the snake Bothrops jararaca (Jararaca)

Toxicon, 1982
Bothropasin, one of the proteases from the venom of Bothrops jararaca active on casein, was isolated by ammonium sulfate precipitation, DEAE-cellulose and DEAE-Sephadex A-50 chromatographies and Sephadex G-100 column filtration. The preparation possessed no other detectable activities which are present in the crude venom.
F R, Mandelbaum, A P, Reichel, M T, Assakura   +2 more
openaire   +2 more sources