Results 31 to 40 of about 4,982 (208)

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source

Harnessing the Natural Toxic Metabolites in COVID‐19

Evidence-Based Complementary and Alternative Medicine, Volume 2022, Issue 1, 2022., 2022
SARS‐CoV‐2 is a novel coronavirus and the cause of the recent pandemic; it is an enveloped β‐coronavirus. SARS‐CoV‐2 appear in the Wuhan City of China for the first time and outspread worldwide quickly. Due to its person‐to‐person fast transmission, COVID‐19 is becoming a global problem.
Ali Bahrami, Mohammad Taheri, Mohammad Reza Arabestani, Meysam Soleimani, Mojdeh Mohammadi, Fatemeh Golabchi, Maryam Banitorfi, Seyed Mostafa Hosseini, Sodabe Khodabandehlou, Fatemeh Nouri, Jelena Zivkovic   +10 more
wiley   +1 more source

Purification of a fragment obtained by autolysis of a PIIIb-SVMP from Bothrops alternatus venom [PDF]

, 2018
Snake Venom Metalloproteinases (SVMPs) represent 43.1% of the components in Bothrops alternatus venom and play an important role in envenomation. Disintegrins and disintegrin-like domains are released by proteolytic processing of PII and PIII classes of ...
Acosta, Ofelia Cristina, Biscoglio, Mirtha Josefa, Bustillo, Soledad, dos Santos, Patty Karina, Gay, Claudia Carolina, Leiva, Laura Cristina Ana, Olivera Moritz, Milene Nobrega de, Rodríguez, Juan Pablo, Sobreiro Selistre de Araujo, Heloisa, Van de Velde, Andrea Carolina   +9 more
core   +1 more source

Snake Venomics and Antivenomics of Bothrops diporus, a Medically Important Pitviper in Northeastern Argentina [PDF]

, 2015
Snake species within genus Bothrops are responsible for more than 80% of the snakebites occurring in South America. The species that cause most envenomings in Argentina, B.
Calvete, Juan J., Gay, Claudia Carolina, Pla, Davinia, Sanz, Libia   +3 more
core   +2 more sources

[Retracted] Chemical Structures and Pharmacological Properties of Typical Bioflavonoids in Polygonati Rhizoma (PGR)

Journal of Environmental and Public Health, Volume 2022, Issue 1, 2022., 2022
Most medicines are coming with toxic and detrimental side effects. In addition, microbials are resisting the medicine. Therefore, alternative drugs with low toxic and side effects and low microbial resistance are needed. Plants offer good potential candidates due to a broad range of chemicals they contain.
Min Luo, Zongren Hu, Zixuan Zhong, Lumei Liu, Chengxiong Lin, Qinghu He, Weiguo Li   +6 more
wiley   +1 more source

CCL‐2 and CXCL‐8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite

Mediators of Inflammation, Volume 2022, Issue 1, 2022., 2022
In the Brazilian Amazon, the snake Bothrops atrox is the primary cause of snakebites. B. atrox (BaV) venom can cause systemic pathophysiological changes such as acute kidney injury (AKI), which leads to the production of chemokines and cytokines in response to the envenomation.
Juliana Costa Ferreira Neves, Hiochelson Najibe Santos Ibiapina, Fábio Magalhães-Gama, Jacqueline Almeida Gonçalves Sachett, Iran Mendonça Silva, Kerolaine Fonseca Coelho, Eliane Campos Alves, Andréa Monteiro Tarragô, Luiz Carlos de Lima Ferreira, Adriana Malheiro, Wuelton Marcelo Monteiro, Allyson Guimarães Costa, Guangtao Xu   +12 more
wiley   +1 more source

Angiotensin-degrading serine peptidase: A new chymotrypsin-like activity in the venom of Bothrops jararaca partially blocked by the commercial antivenom [PDF]

, 2012
Snakebite envenomation is considered a highly relevant public health hazard in South America, having an impact in terms of mortality and morbidity.
Carvalho, Daniela Cajado, Juliano, Luiz, Juliano, Maria Aparecida, Kuniyoshi, Alexandre Kazuo, Portaro, Fernanda Calheta Vieira, Rocha, Marisa, Tambourgi, Denise Vilarinho   +6 more
core   +2 more sources

Factors underlying the natural resistance of animals against snake venoms

Memorias do Instituto Oswaldo Cruz, 1989
The existence of mammals and reptilia with a natural resistance to snake venoms is known since a long time. This fact has been subjected to the study by several research workers.
H. Moussatché, J. Perales
doaj   +1 more source

Popular names for bushmaster (Lachesis muta) and lancehead (Bothrops atrox) snakes in the Alto Juruá region: repercussions for clinical-epidemiological diagnosis and surveillance

Revista da Sociedade Brasileira de Medicina Tropical, 2019
INTRODUCTION: The popular names “surucucu” and “jararaca” have been used in literature for Lachesis muta and Bothrops atrox snakes, respectively.
Ageane Mota da Siva, Wuelton Marcelo Monteiro, Paulo Sérgio Bernarde   +2 more
doaj   +1 more source

Venom-related transcripts from Bothrops jararaca tissues provide novel molecular insights into the production and evolution of snake venom. [PDF]

, 2014
Attempts to reconstruct the evolutionary history of snake toxins in the context of their co-option to the venom gland rarely account for nonvenom snake genes that are paralogous to toxins, and which therefore represent important connectors to ancestral ...
Bastos, Carolina Mancini Val, Casewell, Nicholas, Ho, Paulo Lee, Junqueira-de-Azevedo, Inácio L M, Luna, Milene Schmidt, Yamanouye, Norma   +5 more
core   +3 more sources