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Cocos nucifera Oil Decreases Edema and Mechanical Hypernociception Induced by Bothrops Jararacussu Venom in Mice

Planta Medica International Open, 2017
Bothropic venoms cause intense local damage, pain, edema, and myonecrosis. Cocos nucifera is the naturally most widespread fruit plant on Earth, and both the fruit and the plant have been used in folk medicine for the treatment of several inflammatory ...
Ana Paula de Oliveira, Carlos W S Wanderley   +1 more
exaly   +2 more sources

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Acute local nerve lesions induced by Bothrops jararacussu snake venom

Toxicon, 2002
Myonecrosis is one of the most common effects of Bothrops jararacussu venom, but little is known about the action of this venom on other tissues. In this study, we used transmission electron microscopy to examine the influence of B. jararacussu venom on nerve tissue.
Luciano, de Souza Queiróz, Maria Julia, Marques, Humberto, Santo Neto   +2 more
openaire   +2 more sources

Muscle necrosis and regeneration after envenomation by Bothrops jararacussu snake venom

Toxicon, 1984
The lesions caused by sublethal doses of Bothrops jararacussu venom injected into tibialis anterior (tib. ant.) muscles of mice were studied with paraffin sections. Doses of 5 and 20 micrograms produced a large area of necrosis in tib. ant., but hardly affected neighbouring muscles.
L S, Queiroz, H, Santo Neto, L, Rodrigues-Simioni, J, Prado-Franceschi   +3 more
openaire   +2 more sources

The renal effects of Bothrops jararacussu venom and the role of PLA2 and PAF blockers

Toxicon, 2001
The most common complication in the lethal cases of ophidian bites in Brazil is acute renal failure, but its pathogenesis is obscure. The effects of Bothrops jararacussu venom (3, 10 and 30 microg/ml) were examined using the isolated perfused kidney from Wistar rats.
A, Havt, M C, Fonteles, H S, Monteiro
openaire   +2 more sources

Identification of proteins similar to Bothrops jararaca coagulation inhibitor (BjI) in the plasmas of Bothrops alternatus, Bothrops jararacussu and Crotalus durissus terrificus snakes

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2008
Bothrops jararaca coagulation inhibitor (BjI), a protein isolated from B. jararaca plasma, specifically inhibits the coagulant activity of thrombin. Our group previously identified proteins similar to BjI in the plasma of other snakes [Tanaka-Azevedo, A.M., Tanaka, A.S., Sano-Martins I.S., 2003. A new blood coagulation inhibitor from the snake Bothrops
Karen Batista, de Morais, Kathleen, Fernandes Grego, Anita Mitico, Tanaka-Azevedo   +2 more
openaire   +2 more sources

Isolation and characterization of a new clotting factor from Bothrops jararacussu (jararacuçu) venom

Toxicon, 1997
A detailed procedure for the isolation of a new clotting enzyme from the venom of Bothrops jararacussu (common name jararacuçu) is described. The estimated mol. wt of the native protein was 30,100 but 37,500 after reduction by dithiothreitol.
S H, Andrião-Escarso, S V, Sampaio, O A, Cunha, S, Marangoni, B, Oliveira, J R, Giglio   +5 more
openaire   +2 more sources

Ability of suramin to antagonize the cardiotoxic and some enzymatic activities of Bothrops jararacussu venom

Toxicon, 2008
We have investigated the cardiotoxic effect of Bothrops jararacussu crude venom and the ability of suramin to antagonize this effect in the heart of rats, as well as the proteolytic and phospholipase A(2) (PLA(2)) venom activities. Continuous perfusion in an isolated heart of a rat on a Langendorff preparation with a Ringer's solution with B ...
Daniel N, Sifuentes, Camila Z, El-Kik, Hilmar D, Ricardo, Marcelo A, Tomaz, Marcelo A, Strauch, Sabrina, Calil-Elias, Emerson Z, Arruda, Elisabeth F, Schwartz, Paulo A, Melo   +8 more
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Renal cortical necrosis following Bothrops jararaca and B. jararacussu snake bite

Toxicon, 1985
Out of 22 patients admitted to the Intensive Care Unit of the Hospital das Clínicas, Federal University of Minas Gerais, with acute renal failure following Bothrops snake bite, 7 had renal cortical necrosis. This complication was suspected when the oligoanuric phase ranged from 21 to 28 days or when the patient, in spite of having a polyuric phase ...
C F, Amaral, O A, Da Silva, P, Goody, D, Miranda   +3 more
openaire   +2 more sources

Biologically active peptides from Bothrops jararacussu venom.

Agents and actions. Supplements, 1992
The venom of the Brazilian snake Bothrops jararacussu, was found to contain peptides capable of potentiating the smooth muscle contracting activity of bradykinin (BK). Chromatographic separation on Sephadex G-25 and Sephadex G-10 respectively, yielded an active peptide which at a concentration of 0.6 micrograms/ml doubled the effect of a single dose of
L A, Ferreira, O B, Henriques, I, Lebrun, M B, Batista, B C, Prezoto, A S, Andreoni, R, Zelnik, G, Habermehl   +7 more
openaire   +1 more source

The effects of Bothrops jararacussu venom and its components on frog nerve-muscle preparation

Neuroscience, 1983
The effect of Bothrops jararacussu venom was studied in cutaneous pectoris nerve muscle preparations and in the desheathed sciatic nerve of the frog. The venom rapidly inhibited muscle twitch--tension, evoked either directly or indirectly through the motor nerve and abolished the compound action potential of the muscle and of the sciatic nerve.
L, Rodrigues-Simioni, N, Borgese, B, Ceccarelli   +2 more
openaire   +2 more sources