Results 91 to 100 of about 11,682,231 (209)

Bottom-up synthetic immunology

Infectious diseases and cancer evade immune surveillance using similar mechanisms. Targeting immune mechanisms using common strategies thus represents a promising avenue to improve prevention and treatment.
Göpfrich, K., Platten, M., Frischknecht, F., Fackler, O.   +3 more
core   +1 more source

Synthetic biology, inspired by synthetic chemistry

, 2012
The topic synthetic biology appears still as an 'empty basket to be filled'. However, there is already plenty of claims and visions, as well as convincing research strategies about the theme of synthetic biology.
Nallani, M., Sinner, E. K., M. Nallani, V. Malinova, Malinova, V., W.P. Meier, E.K. Sinner, Meier, W. P., Malinova V, Sinner EK, Nallani M, Meier WP   +11 more
core   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Cytomimetic calcification in chemically self-regulated prototissues

Nature Communications
The fabrication of cytomimetic materials capable of orchestrated and adaptive functions remains a significant challenge in bottom-up synthetic biology. Inspired by the cell/matrix integration of living bone, here we covalently tether distributed single ...
Rui Sun, Zhuping Yin, Molly M. Stevens, Mei Li, Stephen Mann   +4 more
doaj   +1 more source

Analysis of the intrinsic value of life in the context of synthetic biology

Frontiers in Bioengineering and Biotechnology
The ongoing advancements in synthetic biology, employing either “bottom-up” or “top-down” approaches to construct synthetic life, are generating significant interest.
Yi Zhang, Yuling Chen, Bohua Liao
doaj   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Varieties of Noise: Analogical Reasoning in Synthetic Biology [PDF]

, 2013
The picture of synthetic biology as a kind of engineering science has largely created the public understanding of this novel field, covering both its promises and risks.
Knuuttila, Tarja, Loettgers, Andrea
core  

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

A SynBio community comes of age: Political, academical, industrial, and societal developments in the Netherlands

Biotechnology Notes
Synthetic biology (SynBio) is a rapidly growing scientific discipline. In the Netherlands, various universities and companies are tackling a variety of opportunities and challenges within this field.
Darshak K. Bhatt, Marjolein E. Crooijmans, Jelmer Coenradij, Alicia Maciá Valero, Maarten Lubbers, Enrique Asin-Garcia, N. Amy Yewdall, Sarah D'Adamo, Nico J. Claassens, Sonja Billerbeck   +9 more
doaj   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source